Contemporary Forms of Slavery in Brazil

This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide. Special emphasis is placed on labor rights, working conditions, labor market changes, and union organizing.ASI_2006_OSR_Brazil_Contemporary_forms.pdf: 266 downloads, before Oct. 1, 2020

The formation of IRIS diagnostics V. A quintessential model atom of C II and general formation properties of the C II lines at 133.5 nm

The 133.5 nm lines are important observables for the NASA/SMEX mission Interface Region Imaging Spectrograph (IRIS). To make 3D non-LTE radiative transfer computationally feasible it is crucial to have a model atom with as few levels as possible while retaining the main physical processes. We here develop such a model atom and we study the general formation properties of the C II lines. We find that a nine-level model atom of C I-C III with the transitions treated assuming complete frequency redistribution (CRD) suffices to describe the 133.5 nm lines. 3D scattering effects are important for the intensity in the core of the line. The lines are formed in the optically thick regime. The core intensity is formed in layers where the temperature is about 10kK at the base of the transition region. The lines are 1.2-4 times wider than the atomic absorption profile due to the formation in the optically thick regime. The smaller opacity broadening happens for single peak intensity profiles where the chromospheric temperature is low with a steep source function increase into the transition region, the larger broadening happens when there is a temperature increase from the photosphere to the low chromosphere leading to a local source function maximum and a double peak intensity profile with a central reversal. Assuming optically thin formation with the standard coronal approximation leads to several errors: Neglecting photoionization severly underestimates the amount of C II at temperatures below 16kK, erroneously shifts the formation from 10kK to 25kK and leads to too low intensities.Comment: Accepted for publication by the Astrophysical Journa

Long noncoding RNAs in prostate cancer: overview and clinical implications.

Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to castration-resistant prostate cancer (CRPC), which is currently incurable. Thus, there is a critical need to identify biomarkers that will distinguish indolent from aggressive disease, as well as novel therapeutic targets for the prevention or treatment of CRPC. In recent years, long noncoding RNAs (lncRNAs) have emerged as an important class of biological molecules. LncRNAs are polyadenylated RNA species that share many similarities with protein-coding genes despite the fact that they are noncoding (not translated into proteins). They are usually transcribed by RNA polymerase II and exhibit the same epigenetic signatures as protein-coding genes. LncRNAs have also been implicated in the development and progression of variety of cancers, including prostate cancer. While a large number of lncRNAs exhibit tissue- and cancer-specific expression, their utility as diagnostic and prognostic biomarkers is just starting to be explored. In this review, we highlight recent findings on the functional role and molecular mechanisms of lncRNAs in the progression of prostate cancer and evaluate their use as potential biomarkers and therapeutic targets

Contemporary Forms of Slavery in Bolivia

This document is part of a digital collection provided by the Martin P. Catherwood Library, ILR School, Cornell University, pertaining to the effects of globalization on the workplace worldwide. Special emphasis is placed on labor rights, working conditions, labor market changes, and union organizing.ASI_2006_OSR_Bolivia_Contemporary_forms.pdf: 171 downloads, before Oct. 1, 2020

Russia’s summit with ASEAN: Pivot to the East?

Russia is hosting a summit in Sochi on 19-20 May 2016 to commemorate twenty years of its dialogue relations with ASEAN. It will explore further cooperation between the two in another affirmation of Russia’s growing ‘pivot to the east’ policy under President Vladimir Putin, concurrent with its falling-out with the West. What are Russia’s objectives, its ‘Asian’ credentials and the potential for economic and strategic cooperation with ASEAN

A framework for quantification and physical modeling of cell mixing applied to oscillator synchronization in vertebrate somitogenesis

In development and disease, cells move as they exchange signals. One example is found in vertebrate development, during which the timing of segment formation is set by a ‘segmentation clock’, in which oscillating gene expression is synchronized across a population of cells by Delta-Notch signaling. Delta-Notch signaling requires local cell-cell contact, but in the zebrafish embryonic tailbud, oscillating cells move rapidly, exchanging neighbors. Previous theoretical studies proposed that this relative movement or cell mixing might alter signaling and thereby enhance synchronization. However, it remains unclear whether the mixing timescale in the tissue is in the right range for this effect, because a framework to reliably measure the mixing timescale and compare it with signaling timescale is lacking. Here, we develop such a framework using a quantitative description of cell mixing without the need for an external reference frame and constructing a physical model of cell movement based on the data. Numerical simulations show that mixing with experimentally observed statistics enhances synchronization of coupled phase oscillators, suggesting that mixing in the tailbud is fast enough to affect the coherence of rhythmic gene expression. Our approach will find general application in analyzing the relative movements of communicating cells during development and disease.Fil: Uriu, Koichiro. Kanazawa University; JapónFil: Bhavna, Rajasekaran. Max Planck Institute of Molecular Cell Biology and Genetics; Alemania. Max Planck Institute for the Physics of Complex Systems; AlemaniaFil: Oates, Andrew C.. Francis Crick Institute; Reino Unido. University College London; Reino UnidoFil: Morelli, Luis Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigación en Biomedicina de Buenos Aires - Instituto Partner de la Sociedad Max Planck; Argentina. Max Planck Institute for Molecular Physiology; Alemania. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentin

Russia’s Asia Pivot: Engaging the Russian Far East, China and Southeast Asia

The Russia-ASEAN summit being held in Sochi on 19-20 May 2016 to mark twenty years of Russia’s dialogue partnership with ASEAN is a further indicator of President Vladimir Putin’s ‘pivot to Asia’ policy, triggered also by its current confrontation with the west. Through this pivot, Moscow wants to assert Russia’s geopolitical status as a Euro-Pacific as well as AsiaPacific power. It is a pragmatic response to the shifting of global power to Asia. It also builds on the growing Russo-Chinese relations to develop the Russian Far East, a resource-rich but underdeveloped region into the gateway for expansion of Russia into the Asia Pacific. At the same time, the growing asymmetry in achieving the economic and strategic goals of Russia and China has resulted in fears that the Russian Far East will turn into a raw materials appendage of China. Moscow lacks the financial resources to support Putin’s Asia pivot. Therefore, Russia needs to strengthen ties with other Asia-Pacific countries and ASEAN as a regional grouping so as to attract more diversified trade and investments into its Far East region. It is in this context that the Sochi summit takes on added significance. However, given Russia’s sporadic interest in Southeast Asia and its strategic role defined mainly by the limited potential of Russian energy and arms exports to ASEAN Member States, the PR diplomacy and summitry at Sochi may not deliver substantive outcomes for Russia. Nonetheless, Moscow aims to enhance its status in the east and seek business and strategic opportunities through the summit thereby compensating to some extent Russia’s loss following the sanctions imposed by the west over the annexation of Crimea