Sammelrezension Gewalt im Computerspiel

Christoph Bareither: Gewalt im Computerspiel: Facetten eines VergnügensBielefeld: transcript 2016, 364 S., ISBN 9783837635591, EUR 34,99 (Zugl. Dissertation an der Eberhard-Karls-Universität Tübingen, 2015)Gareth Schott: Violent Games: Rules, Realism and EffectLondon/New York: Bloomsbury Academic 2016 (Approaches to Digital Game Studies, Bd.3), 274 S., ISBN 9781628925616,EUR 34,9

Klaus Rothermund, Andreas Eder: Motivation und Emotion. Lehrbuch. Basiswissen Psychologie. Wiesbaden 2011 (Rezension)

Rezension zu Klaus Rothermund/ Andreas Eder: Motivation und Emotion. Lehrbuch. Basiswissen Psychologie. Wiesbaden: VS-Verlag, 201

Schlaglichter: ein Streifzug durch 100 Jahre Institut für Kommunikations- undMedienwissenschaft 1916 – 2016

Die Posterausstellung des Lehr- und Praxisprojekts von Studierenden des Bachelorstudienganges Kommunikations- und Medienwissenschaft anlässlich der 61. Tagung der Deutschen Gesellschaft für Publizistik gibt in Kooperation mit dem Universitätsarchiv Leipzig Einblicke in die wechselvolle Geschichte des Instituts für Kommunikations- und Medienwissenschaft der Universität Leipzig im 100. Jahr seiner Gründung

Modulation of GLO1 expression affects malignant properties of cells

The energy metabolism of most tumor cells relies on aerobic glycolysis (Warburg effect) characterized by an increased glycolytic flux that is accompanied by the increased formation of the cytotoxic metabolite methylglyoxal (MGO). Consequently, the rate of detoxification of this reactive glycolytic byproduct needs to be increased in order to prevent deleterious effects to the cells. This is brought about by an increased expression of glyoxalase 1 (GLO1) that is the rate-limiting enzyme of the MGO-detoxifying glyoxalase system. Here, we overexpressed GLO1 in HEK 293 cells and silenced it in MCF-7 cells using shRNA. Tumor-related properties of wild type and transformed cells were compared and key glycolytic enzyme activities assessed. Furthermore, the cells were subjected to hypoxic conditions to analyze the impact on cell proliferation and enzyme activities. Our results demonstrate that knockdown of GLO1 in the cancer cells significantly reduced tumor-associated properties such as migration and proliferation, whereas no functional alterations where found by overexpression of GLO1 in HEK 293 cells. In contrast, hypoxia caused inhibition of cell growth of all cells except of those overexpressing GLO1. Altogether, we conclude that GLO1 on one hand is crucial to maintaining tumor characteristics of malignant cells, and, on the other hand, supports malignant transformation of cells in a hypoxic environment when overexpressed

\u3ci\u3eIn situ\u3c/i\u3e ellipsometry growth characterization of dual ion beam deposited boron nitride thin films

Pure hexagonal h, as well as mixed-phase cubic/hexagonal c/h boron nitride (BN) thin films were deposited onto [001] silicon substrates using the dual ion beam deposition technique. The BN thin films were grown under UHV conditions at different substrate temperatures and ion beam bombarding parameters. Thin-film growth was monitored using in situ spectroscopic ellipsometry at 44 wavelengths between 420 and 761 nm. The in situ ellipsometric Ψ and Δ data were compared with two-layer growth model calculations for the mixed-phase c/h BN, and with one-layer growth model calculations for pure h-BN growth. In situ data provide information on the optical properties of deposited h-BN and c/h-BN material, film thickness, and BN growth rates. A virtual interface approach is employed for the optical properties of the silicon substrate. The growth and nucleation of c-BN observed here confirms the cylindrical thermal spike model. The results for composition and thickness of the BN films were compared to those obtained from ex situ infrared transmission measurements and high-resolution transmission electron microscopy investigations

The Guinea Pig as a model for sporadic Alzheimer's Disease (AD): the impact of cholesterol intake on expression of AD-related genes

Extent: 12p.We investigated the guinea pig, Cavia porcellus, as a model for Alzheimer’s disease (AD), both in terms of the conservation of genes involved in AD and the regulatory responses of these to a known AD risk factor - high cholesterol intake. Unlike rats and mice, guinea pigs possess an Aβ peptide sequence identical to human Aβ. Consistent with the commonality between cardiovascular and AD risk factors in humans, we saw that a high cholesterol diet leads to up-regulation of BACE1 (β-secretase) transcription and down-regulation of ADAM10 (α-secretase) transcription which should increase release of Aβ from APP. Significantly, guinea pigs possess isoforms of AD-related genes found in humans but not present in mice or rats. For example, we discovered that the truncated PS2V isoform of human PSEN2, that is found at raised levels in AD brains and that increases γ-secretase activity and Aβ synthesis, is not uniquely human or aberrant as previously believed. We show that PS2V formation is up-regulated by hypoxia and a high-cholesterol diet while, consistent with observations in humans, Aβ concentrations are raised in some brain regions but not others. Also like humans, but unlike mice, the guinea pig gene encoding tau, MAPT, encodes isoforms with both three and four microtubule binding domains, and cholesterol alters the ratio of these isoforms. We conclude that AD-related genes are highly conserved and more similar to human than the rat or mouse. Guinea pigs represent a superior rodent model for analysis of the impact of dietary factors such as cholesterol on the regulation of AD-related genes.Mathew J. Sharman, Seyyed H. Moussavi Nik, Mengqi M. Chen, Daniel Ong, Linda Wijaya, Simon M. Laws, Kevin Taddei, Morgan Newman, Michael Lardelli, Ralph N. Martins, Giuseppe Verdil