Autonomous Vehicle Ultrasonic Sensor Vulnerability and Impact Assessment

Vehicles today are relying more on technologies to bring about fully autonomous features. The conventional wirings within are being simplified into a network of electronic components, and this network is controlled via advanced sensing of the environment to make decisions in real-time. However, with the heavy reliance on the sensor readings, any inaccurate reading from the sensors could result in decisions that may cause life-threatening incidents. As such, this research focuses on the in-depth assessment of potential vulnerabilities of an important and commonly used obstacle sensing device, which is the ultrasonic sensor, in modern as well as autonomous vehicles. This research will help bring awareness to the car manufacturers and AV researchers so as to mitigate such issues

Loss-tolerant quantum secure positioning with weak laser sources

Quantum position verification (QPV) is the art of verifying the geographical location of an untrusted party. Recently, it has been shown that the widely studied Bennett & Brassard 1984 (BB84) QPV protocol is insecure after the 3 dB loss point assuming local operations and classical communication (LOCC) adversaries. Here, we propose a time-reversed entanglement swapping QPV protocol (based on measurement-device-independent quantum cryptography) that is highly robust against quantum channel loss. First, assuming ideal qubit sources, we show that the protocol is secure against LOCC adversaries for any quantum channel loss, thereby overcoming the 3 dB loss limit. Then, we analyze the security of the protocol in a more practical setting involving weak laser sources and linear optics. In this setting, we find that the security only degrades by an additive constant and the protocol is able to verify positions up to 47 dB channel loss.Comment: 11 pages, 3 figures. Partially based on an earlier work in arXiv:1510.0489

Perancangan Kemasan Produk "Choco Molten” Online Bakery Instacake Sebagai Media Promosi

Cokelat terbukti memiliki banyak manfaat bagi kesehatan tubuh. Salah satu makanan yang terbuat daricokelat adalah Choco Molten ala Instacake. Choco Molten banyak digemari masyarakat Indonesia karena identiklelehan cokelat didalamnya. Choco Molten biasanya hanya dapat dinikmati di cafe atau restoran. Namun saat ini,Instacake menyediakan Choco Molten yang dapat dinikmati dirumah. Dengan sistem delivery, dibutuhkankemasan yang mampu mengamankan produk selama proses pengiriman. Oleh karena itu, Instacakemembutuhkan kemasan yang mampu memberikan identitas , inovatif, dan menjaga keamanan produknya selamaproses pengantaran

Zfp36l2 is required for self-renewal of early erythroid BFU-E progenitors

Stem cells and progenitors in many lineages undergo self- renewing divisions, but the extracellular and intracellular proteins that regulate this process are largely unknown. Glucocorticoids stimulate red cell formation by promoting self-renewal of early erythroid burst forming unit-erythrocyte (BFU-E) progenitors1-4. Here we show that the RNA binding protein Zfp36l2 is a transcriptional target of the glucocorticoid receptor (GR) in BFU-Es and is required for BFU-E self-renewal. Zfp36l2 is normally downregulated during erythroid differentiation from the BFU-E stage but its expression is maintained by all tested GR agonists that stimulate BFU-E self-renewal, and the GR binds to several potential enhancer regions of Zfp36l2. Knockdown of Zfp36l2 in cultured BFU-E cells did not affect the rate of cell division but disrupted glucocorticoid-induced BFU-E self-renewal, and knockdown of Zfp36l2 in transplanted erythroid progenitors prevented expansion of erythroid lineage progenitors normally seen following induction of anemia by phenylhydrazine treatment. Zfp36l2 preferentially binds to mRNAs that are induced or maintained at high expression levels during terminal erythroid differentiation and negatively regulates their expression levels. Thus Zfp36l2 functions as part of molecular switch promoting BFU-E self-renewal and thus a subsequent increase in the total numbers of CFU-E progenitors and erythroid cells that are generated

Protein Kinase C α Is a Central Signaling Node and Therapeutic Target for Breast Cancer Stem Cells

The epithelial-mesenchymal transition program becomes activated during malignant progression and can enrich for cancer stem cells (CSCs). We report that inhibition of protein kinase C α (PKCα) specifically targets CSCs but has little effect on non-CSCs. The formation of CSCs from non-stem cells involves a shift from EGFR to PDGFR signaling and results in the PKCα-dependent activation of FRA1. We identified an AP-1 molecular switch in which c-FOS and FRA1 are preferentially utilized in non-CSCs and CSCs, respectively. PKCα and FRA1 expression is associated with the aggressive triple-negative breast cancers, and the depletion of FRA1 results in a mesenchymal-epithelial transition. Hence, identifying molecular features that shift between cell states can be exploited to target signaling components critical to CSCs.National Cancer Institute (U.S.) (Grant P01-CA080111)National Institutes of Health (U.S.) (Grant R01-CA078461

Thermal expansion coefficient determination of polylactic acid using digital image correlation

This paper aims determining the linear thermal expansion coefficient (CTE) of polylactic acid (PLA) using an optical method for measuring deformations called digital image correlation method (DIC). Because PLA is often used in making many pieces with 3D printing technology, it is opportune to know this coefficient to obtain a higher degree of precision in the construction of parts and to monitor deformations when these parts are subjected to a thermal gradient. Are used two PLA discs with 20 and 40% degree of filling. In parallel with this approach was determined the linear thermal expansion coefficient (CTE) for the copper cylinder on the surface of which are placed the two discs of PLA

Site-specific incorporation of phosphotyrosine using an expanded genetic code.

Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation. Here we report an efficient method to generate pure, active phosphotyrosine-containing proteins by genetically encoding a stable phosphotyrosine analog that is convertible to native phosphotyrosine. We demonstrate its general compatibility with proteins of various sizes, phosphotyrosine sites and functions, and reveal a possible role of tyrosine phosphorylation in negative regulation of ubiquitination