Order independent structural alignment of circularly permuted proteins

Circular permutation connects the N and C termini of a protein and concurrently cleaves elsewhere in the chain, providing an important mechanism for generating novel protein fold and functions. However, their in genomes is unknown because current detection methods can miss many occurances, mistaking random repeats as circular permutation. Here we develop a method for detecting circularly permuted proteins from structural comparison. Sequence order independent alignment of protein structures can be regarded as a special case of the maximum-weight independent set problem, which is known to be computationally hard. We develop an efficient approximation algorithm by repeatedly solving relaxations of an appropriate intermediate integer programming formulation, we show that the approximation ratio is much better then the theoretical worst case ratio of $r = 1/4$. Circularly permuted proteins reported in literature can be identified rapidly with our method, while they escape the detection by publicly available servers for structural alignment.Comment: 5 pages, 3 figures, Accepted by IEEE-EMBS 2004 Conference Proceeding

Ein Vorkommen der Kleinlibelle Cercion lindeni (Selys, 1840) an der Hase bei Osnabrück

Die Kleinlibelle C. Iindeni wurde erstmals in Südwest-Niedersachsen festgestellt. Von dieser sowie von 14 assoziierten Libellenarten im Beobachtungsgebiet wird die Häufigkeit der Imagines sowie deren Verhalten an sechs Beobachtungstagen innerhalb einer definierten Bachstrecke beschrieben.The damselfly C. Iindeni is recorded for the first time from Southwest Lower Saxony. For this species as weil as for 14 associated Odonata species the abundance of adults asweil as their behaviour is recorded on six obervation periods for a defined section of the river Hase

Zur Libellenfauna der oberen und mittleren Hase : mit 5 Tabellen

Die Beobachtungen zur Libellen-Fauna während der Untersuchungen der mittleren Hase zwischen 1966 und 1968 werden mit einer knappen Erläuterung und 5 Tabellen dargestellt

Libellenfauna der Nette : mit 2 Tabellen

Die Beobachtungen zur Libellenfauna während der Untersuchungen der Nette 1976-1977 werden mit kurzen Erläuterungen und 2 Tabellen dargestellt

Heuristic Modeling of Strong Coupling in Plasmonic Resonators

Strong coupling of plasmonic excitations and dipolar emitters, such as organic molecules, have been studied extensively in the last years. The questions whether strong coupling can be achieved with a single molecule only and how this is unambiguously proven are still under debate. A critical issue of plasmonic in contrast to photonic systems is additional excitonic line broadening, which is often neglected when modeling such systems. This has led to too optimistic design predictions or incorrect interpretation of ambiguous experimental data, for example in models relying on Maxwell solvers without self-consistent incorporation of line broadening effects. In this paper, we present a heuristic modeling approach for strongly coupled systems based on plasmonic nanoparticles and dipolar emitters that accounts for such broadening and elucidates on recent experiments with single emitters. We explicitly focus on a clear and intuitive classical description that utilizes well-established methods, easy to use within typical Maxwell solvers. The heuristic model (i) provides experimentally relevant numbers like emitter densities and spectra (ii) allows to discriminate systems, which can reach the strong coupling regime from those, which can not (iii) allows to identify optimization routes and (iv) nicely matches with experimental findings. In particular, we employ an approach related to quasi normal modes and extinction simulations where the excitonic system is represented by a frequency dependent permittivity. As examples, we investigate two configurations with many, but also single emitters, which have been studied in recent experiments

Markerless assisted rehabilitation system

The project focuses on the use of modern technology to analyze human movement. This analysis turns out to be useful aid for physicians in rehabilitation of patients with limb injuries. This method is more precise than simple observation of the patient through the organ of sight. The proposed system allows markerless determination of deviations between the selected bones and joints, and as a result do not require specialized and expensive equipment. The implemented application presents instructional animation of the exercises and verify the correctness of its performance in real time. The equipment that meets the requirements of the project is the Microsoft Kinect, which is nowadays widely used in the medical field