Development and Design of Energy Efficient Oil-Flooded Screw Compressors

It is estimated that about 17% of the world's generated power is used for compression. Thus all, even minor improvement of the efficiency of compressors will substantially reduce CO2 emission. This paper presents development of family of energy efficient oil-flooded screw compressors for Kirloskar Pneumatic Company Ltd. The developmental techniques adopted to improve efficiency such as introduction of superior 'N' rotor profile, rotor clearance management, performance calculation using 3D CCM (Computational Continuum Mechanics), direct parametric interface to CAD (Computer Aided Design), which contains bearing selection for complete 3D solid modelling. Also, contemporary prototyping and experimental investigation is supported by the fully computerised data acquisition and processing. The cumulative improvement of all these elements of the design process resulted in a very efficient machine which guarantees the competitive position of Kirloskar Pneumatic Company Limited in the screw compressor market

The first newspapers of Tierra del Fuego, Antarctica, and South Atlantic Islands as national documentary and bibliographic heritage of Argentina

El propósito de esta investigación es explorar y visibilizar los primeros periódicos editados en Ushuaia durante las primeras décadas del Siglo XX, profundizando en la época del “Periodismo Carcelario” ocurrido en el presidio del Fin del Mundo, Tierra del Fuego Antártida e Islas del Atlántico Sur. Además, aborda el concepto de Patrimonio Documental Bibliográfico desde el punto de vista de la clasificación externa de los documentos. Este trabajo se realizó mediante un estudio exploratorio, con una metodología cualitativa y un diseño metodológico semiestructurado entre 2022 y 2023. Se concluye presentando algunas reflexiones y aseveraciones sobre el concepto y tratamiento del esta clase de documentos patrimoniales, a los cuales no solo se valora según su antigüedad, sino también por otros factores relacionados con la historia y la cultura de su origen.The purpose of this research is to explore and bring visibility to the first newspapers published in Ushuaia during the early decades of the 20th century, delving into the era of "Prison Journalism" that took place at the End of the World prison in Tierra del Fuego, Antarctica, and the South Atlantic Islands. Additionally, it addresses the concept of Documentary Bibliographic Heritage from the perspective of the external classification of documents. This work was conducted through an exploratory study, using a qualitative methodology and a semi-structured methodological design between 2022 and 2023. It concludes with reflections and assertions on the concept and treatment of this type of heritage documents, which are valued not only for their age but also for other factors related to the history and culture of their origin.Facultad de Humanidades y Ciencias de la Educació

Online Neuro-Adaptive Learning For Power System Dynamic State Estimation

With the increased penetration of renewable generation in the smart grid , it is crucial to have knowledge of rapid changes of system states. The information of real-time electro-mechanical dynamic states of generators are essential to ensuring reliability and detecting instability of the grid. The conventional SCADA based Dynamic State Estimation (DSE) was limited by the slow sampling rates (2-4 Hz). With the advent of PMU based synchro-phasor technology in tandem with Wide Area Monitoring System (WAMS), it has become possible to avail rapid real-time measurements at the network nodes. These measurements can be exploited for better estimates of system dynamic states. In this research, we have proposed a novel Artificial Intelligence (AI) based real-time neuro-adaptive algorithm for rotor angle and speed estimation of synchronous generators. Generator swing equations and power flow models are incorporated in the online learning. The algorithm learns and adapts in real-time to achieve accurate estimates. Simulation is carried out on 68 bus 16 generator NETS-NYPS model. The neuro-adaptive algorithm is compared with classical Kalman Filter based DSE. Applicability and accuracy of the proposed method is demonstrated under the influence of noise and faulty conditions

El Museo del Fin del Mundo como instrumento transmisor de valores democráticos y ciudadanos en la comunidad educativa de la ciudad de Ushuaia: El caso de la actividad denominada “Proceso de provincialización y constitución de Tierra del Fuego, AeIAS”

The main objective of this contribution is to account for the contribution of the activity named "Provincialization process and constitution of Tierra del Fuego, AeIAS" to the construction of democratic and citizen values in the educational community, especially in the secondary school through the End of the World Museum, in the city of Ushuaia, capital of Tierra del Fuego AeIAS. The aforementioned proposal, currently dictated by Professor Romina Birari with the objective of identifying, recognizing and characterizing citizenship based on the rights and duties of the Provincial Constitution, as well as analyzing and recognizing the actors involved in that episode, with their interests, motivations and intentions, has been designed for the sixth and seventh years of Technical Schools, since by Provincial Law No. 1051, they are the ones who must swear allegiance to the Provincial Constitution, resulting in an experience that allows to value the Old House of Government, annex of the institution.La presente contribución tiene como objetivo principal el dar cuenta del aporte de la actividad denominada “Proceso de provincialización y constitución de Tierra del Fuego, AeIAS” a la construcción de valores democráticos y ciudadanos en la comunidad educativa local, especialmente en el nivel secundario a través del Museo del Fin del Mundo, de la ciudad de Ushuaia, capital de Tierra del Fuego AeIAS. Dicha propuesta, dictada actualmente por la profesora Romina Birari, con el objetivo de identificar, reconocer y caracterizar la ciudadanía en base a los derechos y deberes plasmados en la Constitución Provincial, como así también analizar y reconocer a los actores involucrados en dicha gesta, con sus intereses, motivaciones e  intencionalidades, ha sido pensada para los sextos y séptimos años de Escuelas Técnicas, dado que por Ley Provincial N° 1051, son quienes deben jurar lealtad a la Constitución Provincial, resultando, además, en una experiencia que permite poner en valor a la Antigua Casa de Gobierno, anexo de la institución

Las bibliotecas escolares más allá de los procesos técnicos y la promoción a la lectura : las bibliotecas escolares como espacios contraculturales

The following article explores and questions the concepts of the school library and its limited dissemination regarding cultural extension and the various types of activities that can be carried out inside and out side this space. With in this frame work, the article poses a doublé question: the role of school libraries as countercultural sites in the information age, and the invisibility of these learning and non-formal education spaces in the curricula of different library science programs, teacher training programs, and universities in Argentina.El siguiente ensayo explora y cuestiona los conceptos de la biblioteca escolar y su poca difusión en cuanto a la extensión cultural y los distintos tipos de actividades que se pueden llevar a cabo dentro y fuera de este espacio. En este marco, el escrito sugiere un doble interrogante: el rol de las bibliotecas escolares como sitios contraculturales en la era de la información, y la invisibilización de estos lugares de aprendizaje y de educación no formal en los diseños curriculares de las diferentes carreras de bibliotecología, de los profesorados y de las universidades de Argentina

Integrated Approach for Emotion Detection via Speech and Text Analysis

This paper aims to provide a comprehensive solution for effective reviews using deep learning models. Customers often have difficulty to find accurate reviews of the things they are interested in. The proposed framework implements a review mechanism to address this problem, which will give customers relevant reviews based on video reviews supplied in the product description. The goal of this system is to turn video reviews into a particular rating so that viewers may get a summary of the review without having to watch the full thing by simply glancing at the rating. Deep learning neural networks are used by the model for both text and audio processing in order to achieve this. The well-known RAVDESS dataset serves as the basis for the audio model's training and offers a wide range of emotional expressions. The suggested system uses two methods to provide reviews: text-based natural language processing and audio frequency spectrograms. By utilizing these two techniques, it may provide consumers accurate and trustworthy ratings while guaranteeing that the review procedure is not impeded. The aim is achieved with high accuracy to ensure that users can make informed decisions when purchasing products based on the provided reviews. With the aid of this review system, customers will be able to quickly find out crucial details about a product they are interested in, thus increasing their pleasure and loyalty

Assessing the Impact of Health Policy Reforms on Vulnerable Populations: A Social Science Perspective

Through the view of social science, this study takes a critical look at how changes to health policy affect people who are already at risk. As countries around the world make big changes to their health care systems, it's important to figure out how these changes affect weak and marginalised groups. Our study uses a social science approach to look into how changing health policies affect the lives of disadvantaged groups by exploring the complex web of social, economic, and cultural factors that affect them. The method uses a mix of quantitative and qualitative data analysis, with conversations and focus group talks with people from a range of disadvantaged groups to get more in-depth ideas. Through a broad lens, we want to find out the complex ways that changes in health policy interact with social factors that affect health, affecting the availability, cost, and quality of healthcare for weak groups. Early results show that vulnerable groups bear an unfair amount of the load, showing differences in healthcare outcomes, hurdles to entry, and differences in healthcare service. The study also explores the role of social support networks, community engagement, and cultural competence in mitigating or exacerbating the effects of health policy reforms on vulnerable populations.The implications of this research extend beyond academia, offering practical insights for policymakers, healthcare professionals, and advocacy groups to formulate inclusive policies that address the unique needs of vulnerable populations. By fostering a deeper understanding of the social dynamics at play, this study contributes to the ongoing discourse on health equity and informs evidence-based interventions aimed at safeguarding the health and well-being of society's most marginalized members

Xanthine Oxidase-Derived ROS Upregulate Egr-1 via ERK1/2 in PA Smooth Muscle Cells; Model to Test Impact of Extracellular ROS in Chronic Hypoxia

Exposure of newborn calves to chronic hypoxia causes pulmonary artery (PA) hypertension and remodeling. Previous studies showed that the redox-sensitive transcription factor, early growth response-1 (Egr-1), is upregulated in the PA of chronically hypoxic calves and regulates cell proliferation. Furthermore, we established in mice a correlation between hypoxic induction of Egr-1 and reduced activity of extracellular superoxide dismutase (EC-SOD), an antioxidant that scavenges extracellular superoxide. We now hypothesize that loss of EC-SOD in chronically hypoxic calves leads to extracellular superoxide-mediated upregulation of Egr-1. To validate our hypothesis and identify the signaling pathways involved, we utilized PA tissue from normoxic and chronically hypoxic calves and cultured calf and human PA smooth muscle cells (PASMC). Total SOD activity was low in the PA tissue, and only the extracellular SOD component decreased with hypoxia. PA tissue of hypoxic calves showed increased oxidative stress and increased Egr-1 mRNA. To mimic the in vivo hypoxia-induced extracellular oxidant imbalance, cultured calf PASMC were treated with xanthine oxidase (XO), which generates extracellular superoxide and hydrogen peroxide. We found that 1) XO increased Egr-1 mRNA and protein, 2) XO induced the phosphorylation of ERK1/2 and, 3) pretreatment with an ERK1/2 inhibitor prevented induction of Egr-1 by XO. siRNA knock-down of EC-SOD in human PASMC also upregulated Egr-1 mRNA and protein, activated ERK1/2, and enhanced SMC proliferation and reduced apoptosis. We conclude that an oxidant/antioxidant imbalance arising from loss of EC-SOD in the PA with chronic hypoxia induces Egr-1 via activation of ERK1/2 and contributes to pulmonary vascular remodeling

Formulation and Evaluation of Budesonide-loaded Nanosponges for Colon-specific Drug Delivery Systems

Background: The purpose of this work was to complex budesonide with cyclodextrin-based nanosponges to improve its solubility and stability. The current study focused on polysaccharide systems that have undergone minimal chemical alteration and have been used to target the colon. These targeted delivery and polysaccharide-based complexation methods are anticipated to aid in the creation of medication formulations for disorders affecting the colon, such as colorectal cancer. The goal of the current work was to use a Quality by Design (QbD) strategy to create budesonide-loaded nanosponges. The system consisted of nanosponges loaded with budesonide. Methods: Nanosponges were formulated through microwave-assisted synthesis. Studies on drug release were conducted with a method changing power of hydrogen (pH) with enzyme. Quality by Design-based optimization with a 32 full factorial design was applied for the optimization of the process parameters including the β-cyclodextrin:diphenyl carbonate ratio and the reaction time. Responses were measured for three dependent variables: practical yield, percentage drug release, and percentage drug release at the fifth hour. Results and Conclusions: The optimization model indicated a yield of 76.21%, a percentage drug release at the fifth hour of 24.61%, and a total drug release after 7 hours of 87.58%. The observed responses of the optimized process closely matched the predicted values. The above budesonide-loaded nanosponge formulations provide a targeted medicine for the colon and may be an effective method for treating colonic illness

Current and Future Drug Targets in Weight Management

Obesity will continue to be one of the leading causes of chronic disease unless the ongoing rise in the prevalence of this condition is reversed. Accumulating morbidity figures and a shortage of effective drugs have generated substantial research activity with several molecular targets being investigated. However, pharmacological modulation of body weight is extremely complex, since it is essentially a battle against one of the strongest human instincts and highly efficient mechanisms of energy uptake and storage. This review provides an overview of the different molecular strategies intended to lower body weight or adipose tissue mass. Weight-loss drugs in development include molecules intended to reduce the absorption of lipids from the GI tract, various ways to limit food intake, and compounds that increase energy expenditure or reduce adipose tissue size. A number of new preparations, including combinations of the existing drugs topiramate plus phentermine, bupropion plus naltrexone, and the selective 5-HT2C agonist lorcaserin have recently been filed for approval. Behind these leading candidates are several other potentially promising compounds and combinations currently undergoing phase II and III testing. Some interesting targets further on the horizon are also discussed