Means and Meanings of Research Collaboration in the Face of a Suffering Earth : A Landscape of Questions

Peer reviewe

Primary oral manifestation of Langerhans cell histiocytosis refractory to conventional therapy but susceptible to BRAF-specific treatment: a case report and review of the literature

Langerhans cell histiocytosis (LCH) is a diagnostic and therapeutic challenge. We report on a rare case of its primary oral manifestation that was treated successfully with the BRAF-specific agent, vemurafenib, after insufficient standard LCH treatment. This case underlines the importance of proper diagnosis and the evaluation of targeted therapy as a valuable tool in LCH treatment. Furthermore, the close collaboration of surgeons, oncologists, and dentists is mandatory to ensure adequate treatment, restore the stomatognathic system in debilitating post-treatment situations, improve quality of life, and ensure effective disease control in infants and young patients

Essen und Verantwortung.

Unterliegen wir als aufgeklärte Konsument*innen angesichts der globalen Auswirkungen unserer täglichen Ernährungsentscheidungen tatsächlich einer "selbstverschuldeten Unmündigkeit" hinsichtlich eines verantwortlichen Umgangs mit Ernährung? Der Beitrag argumentiert für die These, dass strukturelle Gründe den "Ausgang aus der gastrosophischen Unmündigkeit" verkomplizieren, diesen aber nicht unmöglich machen

Effects of sevoflurane and its metabolite hexafluoroisopropanol on hypoxia/reoxygenation-induced injury and mitochondrial bioenergetics in murine cardiomyocytes

Background The volatile anaesthetic sevoflurane protects cardiac tissue from reoxygenation/reperfusion. Mitochondria play an essential role in conditioning. We aimed to investigate how sevoflurane and its primary metabolite hexafluoroisopropanol (HFIP) affect necrosis, apoptosis, and reactive oxygen species formation in cardiomyocytes upon hypoxia/reoxygenation injury. Moreover, we aimed to describe the similarities in the mode of action in a mitochondrial bioenergetics analysis. Methods Murine cardiomyocytes were exposed to hypoxia (0.2% O2 for 6 h), followed by reoxygenation (air with 5% CO2 for 2 h) in the presence or absence sevoflurane 2.2% or HFIP 4 mM. Lactate dehydrogenase (LDH) release (necrosis), caspase activation (apoptosis), reactive oxygen species, mitochondrial membrane potential, and mitochondrial function (Seahorse XF analyser) were measured. Results Hypoxia/reoxygenation increased cell death by 44% (+31 to +55%, P<0.001). Reoxygenation in the presence of sevoflurane 2.2% or HFIP 4 mM increased LDH release only by +18% (+6 to +30%) and 20% (+7 to +32%), respectively. Apoptosis and reactive oxygen species formation were attenuated by sevoflurane and HFIP. Mitochondrial bioenergetics analysis of the two substances was profoundly different. Sevoflurane did not influence oxygen consumption rate (OCR) or extracellular acidification rate (ECAR), whereas HFIP reduced OCR and increased ECAR, an effect similar to oligomycin, an adenosine triphosphate (ATP) synthase inhibitor. When blocking the metabolism of sevoflurane into HFIP, protective effects of sevoflurane – but not of HFIP – on LDH release and caspase were mitigated. Conclusion Together, our data suggest that sevoflurane metabolism into HFIP plays an essential role in cardiomyocyte postconditioning after hypoxia/reoxygenation injury

Do público e do privado: uma perspectiva de género sobre uma dicotomia moderna

Neste texto propomos uma interpretação crítica da dicotomia histórica entre público e privado como dinâmica fundamental da modernidade. A partir de uma perspectiva de género, discutimos as fronteiras construídas entre espaço coletivo de cidadania e de sociabilidade e espaço individual de intimidade e desigualdade. Argumentamos a favor de uma relação de cumplicidade, ainda que tensa, entre as duas esferas, observando que a vida privada foi, em grande medida, moldada pelas mudanças operadas na vida pública. Recorrendo a diferentes definições de "público", notamos que, à medida que as sociabilidades tradicionais, essencialmente masculinas, estudadas entre outros por Ariès ou Sennett, sofriam uma erosão, crescia o sentimento de intimidade, aumentando igualmente a inclusão do privado no público através do alargamento da cidadania, em consequência das lutas travadas na esfera pública por vários movimentos de emancipação, como o operário ou o feminista. À medida que a pessoa era retirada da comunidade, do clã, do grupo de parentesco, em que eram "naturais" as desigualdades, no sentido aristotélico do termo, ia-se reencontrando progressivamente como indivíduo portador de cidadania. Se o espaço privado se tornou central na definição de uma identidade, ele é também crescentemente atravessado por mecanismos públicos de regulação. Nesse sentido, o movimento de ascensão do privado, que nas últimas décadas tem ocupado espaço de debate, deve ser cuidadosamente reinterpretado

Editorial

Liebe Leserinnen und Leser! Wir freuen uns, die zweite Ausgabe 2023 der Zeitschrift für Praktische Philosophie vorlegen zu können. In der offenen Sektion sind vier Beiträge versammelt: Andreas Cassee und Sabine Hohl legen eine Kritik der allgemeinen Dienstpflicht vor, Anita Horn schreibt über Dissoziation als Konzept der Ethik und Sozialkritik, der Text von Bastian Ronge widmet sich Simon Weils Verständnis der Arbeitsteilung und Miriam Schröder hat einen Beitrag über Natur und Nichtidentität mit Blick auf Theodor W. Adorno und Donna J. Haraway verfasst. Der Schwerpunkt in dieser Ausgabe wurde von Janina Loh und Michael Kühler betreut und enthält sechs Texte zu philosophischen Fragen der Polyamorie. Wir danken den Autor:innen und insbesondere den Gutachter:innen, die sich die Mühe machen, die eingereichten Texte gründlich zu lesen und zu kommentieren, und auf diese Weise sicherstellen, dass die ZfPP ihren hohen Qualitätsansprüchen gerecht wird. Wir danken dem Open-Access- Publikationsfonds der Universität Salzburg für die finanzielle Unterstützung zur Herausgabe der Zeitschrift für Praktische Philosophie. Mit dieser Ausgabe verabschieden wir Sarah Bianchi aus dem Kreis der Herausgeber:innen. Wir danken ihr herzlich für ihr Engagement für die ZfPP und wünschen ihr alles Gute für die Zukunft. Die Herausgeber:innen Birgit Beck, Karoline Reinhardt Gottfried Schweiger & Michael Zich