Fermionic extensions of the Standard Model in light of the Higgs couplings

As the Higgs boson properties settle, the constraints on the Standard Model extensions tighten. We consider all possible new fermions that can couple to the Higgs, inspecting sets of up to four chiral multiplets. We confront them with direct collider searches, electroweak precision tests, and current knowledge of the Higgs couplings. The focus is on scenarios that may depart from the decoupling limit of very large masses and vanishing mixing, as they offer the best prospects for detection. We identify exotic chiral families that may receive a mass from the Higgs only, still in agreement with the $h\gamma\gamma$ signal strength. A mixing $\theta$ between the Standard Model and non-chiral fermions induces order $\theta^2$ deviations in the Higgs couplings. The mixing can be as large as $\theta\sim 0.5$ in case of custodial protection of the $Z$ couplings or accidental cancellation in the oblique parameters. We also notice some intriguing effects for much smaller values of $\theta$, especially in the lepton sector. Our survey includes a number of unconventional pairs of vector-like and Majorana fermions coupled through the Higgs, that may induce order one corrections to the Higgs radiative couplings. We single out the regions of parameters where $h\gamma\gamma$ and $hgg$ are unaffected, while the $h\gamma Z$ signal strength is significantly modified, turning a few times larger than in the Standard Model in two cases. The second run of the LHC will effectively test most of these scenarios.Comment: v2: a few clarifications and references added, improved treatment of the constraint from Z-b-bbar, Higgs couplings updated by using the combined ATLAS+CMS fi

Non-perturbative analysis of the spectrum of meson resonances in an ultraviolet-complete composite-Higgs model

We consider a vector-like gauge theory of fermions that confines at the multi-TeV scale, and that realizes the Higgs particle as a composite Goldstone boson. The weak interactions are embedded in the unbroken subgroup $Sp(4)$ of a spontaneously broken $SU(4)$ flavour group. The meson resonances appear as poles in the two-point correlators of fermion bilinears, and include the Goldstone bosons plus a massive pseudoscalar $\eta'$, as well as scalars, vectors and axial vectors. We compute the mass spectrum of these mesons, as well as their decay constants, in the chiral limit, in the approximation where the hypercolour $Sp(2N)$ dynamics is described by four-fermion operators, \`a la Nambu-Jona Lasinio. By resumming the leading diagrams in the $1/N$ expansion, we find that the spin-one states lie beyond the LHC reach, while spin-zero electroweak-singlet states may be as light as the Goldstone-boson decay constant, $f\sim 1$ TeV. We also confront our results with a set of available spectral sum rules. In order to supply composite top-quark partners, the theory contains additional fermions carrying both hypercolour and ordinary colour, with an associated flavour symmetry-breaking pattern $SU(6)/SO(6)$. We identify and analyse several non-trivial features of the complete two-sector gauge theory: the 't~Hooft anomaly matching conditions; the higher-dimension operator which incorporates the effects of the hypercolour axial-singlet anomaly; the coupled mass-gap equations; the mixing between the singlet mesons of the two sectors, resulting in an extra Goldstone boson $\eta_0$, and novel spectral sum rules. Assuming that the strength of the four-fermion interaction is the same in the two sectors, we find that the coloured vector and scalar mesons have masses $\gtrsim 4 f$, while the masses of coloured pseudo-Goldstone bosons, induced by gluon loops, are $\gtrsim 1.5f$.Comment: v1: 65 pages, 25 figures. v2: 70 pages, 29 figures; several references and clarifications included; two additional subsections on the S-parameter and on the spectral sum rules for mixed meson

Two Higgs doublets to explain the excesses pp→γγ(750 GeV)pp\rightarrow \gamma\gamma(750\ {\rm GeV}) and h→τ±μ∓h \to \tau^\pm \mu^\mp

The two Higgs doublet model emerges as a minimal scenario in which to address, at the same time, the $\gamma\gamma$ excess at 750 GeV and the lepton flavour violating decay into $\tau^\pm \mu^\mp$ of the 125 GeV Higgs boson. The price to pay is additional matter to enhance the $\gamma\gamma$ rate, and a peculiar pattern for the lepton Yukawa couplings. We add TeV scale vector-like fermions and find parameter space consistent with both excesses, as well as with Higgs and electroweak precision observables.Comment: 15 pages, 1 figure; v2: discussion of tau-->mu gamma added, leading to an additional constraint. v3: references added, figure 1 recovered and figure 2 adde

Treatment of complex fractures of the distal radius: a prospective randomised comparison of external fixation 'versus' locked volar plating

The traditional treatment of severely impacted fractures of the distal radius involves bridging external fixation and maintaining reduction by applying continuous traction. The recent technique using fixed-angle screws within volar plates is reported restore the radial length and the articular profile whilst avoiding joint distraction. It is also believed to produce better and quicker clinical results. To test these claims, we carried out a randomised controlled comparison of the efficiency of external fixation (EF) \u27versus\u27 open reduction and internal fixation (ORIF) in treating severely impacted fractures of the distal radius. A total of 39 patients were treated with EF, eventually associated with percutaneous pinning, whereas 36 underwent ORIF with a locked volar plate. There was no significant difference in the two groups with regard to changes in the ulnar variance. Articular reduction was poor in two patients in the EF group with residual step-offs exceeding 2mm; another patient of the EF group suffered a secondary loss of reduction, healing with a severe articular malunion (>2mm). By contrast, articular reduction was satisfactory in all the patients of the ORIF group. The clinical results on the Green and O\u27Brien rating were significantly better in the ORIF group than in the EF group (p<0.01 at 6 weeks, p<0.05 at 6 months). Nevertheless, open reduction and volar plating did not yield better subjective results than EF. However, although not statistically significant, patients treated by ORIF seemed to resume their usual activities quicker than those treated with EF, suggesting that this technique may be adapted to a greater extent in the case of active, young individuals

Aluminum and bone: Review of new clinical circumstances associated with Al(3+) deposition in the calcified matrix of bone

Several decades ago, aluminum encephalopathy associated with osteomalacia has been recognized as the major complication of chronic renal failure in dialyzed patients. Removal of aluminum from the dialysate has led to a disappearance of the disease. However, aluminum deposit occurs in the hydroxyapatite of the bone matrix in some clinical circumstances that are presented in this review. We have encountered aluminum in bone in patients with an increased intestinal permeability (coeliac disease), or in the case of prolonged administration of aluminum anti-acid drugs. A colocalisation of aluminum with iron was also noted in cases of hemochromatosis and sickle cell anemia. Aluminium was also identified in a series of patients with exostosis, a frequent benign bone tumor. Corrosion of prosthetic implants composed of grade V titanium (TA6V is an alloy containing 6% aluminum and 4% vanadium) was also observed in a series of hip or knee revisions. Aluminum can be identified in undecalcified bone matrix stained by solochrome azurine, a highly specific stain allowing the detection of 0.03 atomic %. Colocalization of aluminum and iron does not seem to be the fruit of chance but the cellular and molecular mechanisms are still poorly understood. Histochemistry is superior to spectroscopic analyses (EDS and WDS in scanning electron microscopy)

A new mouse model for the trisomy of the Abcg1-U2af1 region reveals the complexity of the combinatorial genetic code of down syndrome

Mental retardation in Down syndrome (DS), the most frequent trisomy in humans, varies from moderate to severe. Several studies both in human and based on mouse models identified some regions of human chromosome 21 (Hsa21) as linked to cognitive deficits. However, other intervals such as the telomeric region of Hsa21 may contribute to the DS phenotype but their role has not yet been investigated in detail. Here we show that the trisomy of the 12 genes, found in the 0.59 Mb (Abcg1-U2af1) Hsa21 sub-telomeric region, in mice (Ts1Yah) produced defects in novel object recognition, open-field and Y-maze tests, similar to other DS models, but induces an improvement of the hippocampal-dependent spatial memory in the Morris water maze along with enhanced and longer lasting long-term potentiation in vivo in the hippocampus. Overall, we demonstrate the contribution of the Abcg1-U2af1 genetic region to cognitive defect in working and short-term recognition memory in DS models. Increase in copy number of the Abcg1-U2af1 interval leads to an unexpected gain of cognitive function in spatial learning. Expression analysis pinpoints several genes, such as Ndufv3, Wdr4, Pknox1 and Cbs, as candidates whose overexpression in the hippocampus might facilitate learning and memory in Ts1Yah mice. Our work unravels the complexity of combinatorial genetic code modulating different aspect of mental retardation in DS patients. It establishes definitely the contribution of the Abcg1-U2af1 orthologous region to the DS etiology and suggests new modulatory pathways for learning and memor