Road user charging and implications for transport policy: Findings from the CURACAO project

This paper reports on the outcomes of a European project, CURACAO, designed to support the implementation of urban road user charging (URUC) as a demand management tool in urban areas. The project did this through engagement with a User Group of cities interested in pursuing URUC to identify the barriers preventing them from doing so. The project reviewed the complete process of setting up a URUC scheme from the setting of objectives, through to scheme design, predicting impacts, achieving acceptability and the implementation process and presented its findings in a State of the Art Report and a Case Studies Report. The State of the Art Report provides evidence collated from research and practice to address a series of 14 themes identified by the User Group, including objectives; scheme design; technology; business systems; prediction; traffic, environmental, economic and equity impacts; appraisal; acceptability; transferability; implementation; and evaluation. The Case Study Report reviewed 16 proposed or implemented schemes in Europe, focusing on pricing objectives, scheme design, the implementation process and scheme results. On this basis, the CURACAO Consortium developed a list of policy recommendations aimed at cities and regional authorities, national governments, and the European Commission. The paper summarises the main findings of the State of the Art Report and the case studies. On this basis, it outlines the policy recommendations which were drawn, and identifies future research needs

The quantification of wind turbulence by means of the fourier dimension

Signal Processing within the frequency domain has long been associated with electrical engineering as a means to quantify the characteristics of voltage/current waveforms. Historically, wind speed data (speed/direction) have been captured and stored as statistical markers within a time series description. This form of storage, while cumbersome, is applicable in wind regimes that are relatively laminar. In urban environments, where the associated topographies and building morphologies are heterogeneous, wind speeds are highly turbulent and chaotic. In such environments and with particular reference to wind energy, time series statistics are of limited use, unless the generic probability distribution function (PDF) is also considered. Furthermore, the industry standard metric that quantifies the turbulent component of wind speed, Turbulence Intensity (TI), is computationally cumbersome and resource intensive. An alternative model to quantify turbulence is proposed here. This paper will describe how Fourier dimension modelling (Df), through linkage with the Weibull probability density function, can quantify turbulence in a more efficient manner. This model could potentially be developed to facilitate urban wind power prediction and is relevant to the planning and development considerations within the built environment

Analysis of heating rates and forces on bodies subject to rocket exhaust plume impingement

Computer programs and engineering methods for calculating heating rates and forces in jet plume impingement problem

Direct observation of hierarchical protein dynamics

One of the fundamental challenges of physical biology is to understand the relationship between protein dynamics and function. At physiological temperatures, functional motions arise from the complex interplay of thermal motions of proteins and their environments. Here, we determine the hierarchy in the protein conformational energy landscape that underlies these motions, based on a series of temperature-dependent magic-angle spinning multinuclear nuclear-magnetic-resonance relaxation measurements in a hydrated nanocrystalline protein. The results support strong coupling between protein and solvent dynamics above 160 kelvin, with fast solvent motions, slow protein side-chain motions, and fast protein backbone motions being activated consecutively. Low activation energy, small-amplitude local motions dominate at low temperatures, with larger-amplitude, anisotropic, and functionally relevant motions involving entire peptide units becoming dominant at temperatures above 220 kelvin

The Serums Tool-Chain:Ensuring Security and Privacy of Medical Data in Smart Patient-Centric Healthcare Systems

Digital technology is permeating all aspects of human society and life. This leads to humans becoming highly dependent on digital devices, including upon digital: assistance, intelligence, and decisions. A major concern of this digital dependence is the lack of human oversight or intervention in many of the ways humans use this technology. This dependence and reliance on digital technology raises concerns in how humans trust such systems, and how to ensure digital technology behaves appropriately. This works considers recent developments and projects that combine digital technology and artificial intelligence with human society. The focus is on critical scenarios where failure of digital technology can lead to significant harm or even death. We explore how to build trust for users of digital technology in such scenarios and considering many different challenges for digital technology. The approaches applied and proposed here address user trust along many dimensions and aim to build collaborative and empowering use of digital technologies in critical aspects of human society

Analyzing Forensic Evidence Based on Density with Magnetic Levitation

This paper describes a method for determining the density of contact trace objects with magnetic levitation (MagLev). MagLev measurements accurately determine the density (±0.0002 g/cm3) of a diamagnetic object and are compatible with objects that are nonuniform in shape and size. The MagLev device (composed of two permanent magnets with like poles facing) and the method described provide a means of accurately determining the density of trace objects. This method is inexpensive, rapid, and verifiable and provides numerical values—independent of the specific apparatus or analyst—that correspond to the absolute density of the sample that may be entered into a searchable database. We discuss the feasibility of MagLev as a possible means of characterizing forensic-related evidence and demonstrate the ability of MagLev to (i) determine the density of samples of glitter and gunpowder, (ii) separate glitter particles of different densities, and (iii) determine the density of a glitter sample that was removed from a complex sample matrix.Chemistry and Chemical Biolog

Spiders have rich pigmentary and structural colour palettes

Elucidating the mechanisms of colour production in organisms is important for understanding how selection acts upon a variety of behaviours. Spiders provide many spectacular examples of colours used in courtship, predation, defence and thermoregulation, but are thought to lack many types of pigments common in other animals. Ommochromes, bilins and eumelanin have been identified in spiders, but not carotenoids or melanosomes. Here, we combined optical microscopy, refractive index matching, confocal Raman microspectroscopy and electron microscopy to investigate the basis of several types of colourful patches in spiders. We obtained four major results. First, we show that spiders use carotenoids to produce yellow, suggesting that such colours may be used for condition-dependent courtship signalling. Second, we established the Raman signature spectrum for ommochromes, facilitating the identification of ommochromes in a variety of organisms in the future. Third, we describe a potential new pigmentary-structural colour interaction that is unusual because of the use of long wavelength structural colour in combination with a slightly shorter wavelength pigment in the production of red. Finally, we present the first evidence for the presence of melanosomes in arthropods, using both scanning and transmission electron microscopy, overturning the assumption that melanosomes are a synapomorphy of vertebrates. Our research shows that spiders have a much richer colour production palette than previously thought, and this has implications for colour diversification and function in spiders and other arthropods

Outcome of ATP-based tumor chemosensitivity assay directed chemotherapy in heavily pre-treated recurrent ovarian carcinoma

BACKGROUND: We wished to evaluate the clinical response following ATP-Tumor Chemosensitivity Assay (ATP-TCA) directed salvage chemotherapy in a series of UK patients with advanced ovarian cancer. The results are compared with that of a similar assay used in a different country in terms of evaluability and clinical endpoints. METHODS: From November 1998 to November 2001, 46 patients with pre-treated, advanced ovarian cancer were given a total of 56 courses of chemotherapy based on in-vitro ATP-TCA responses obtained from fresh tumor samples or ascites. Forty-four patients were evaluable for results. Of these, 18 patients had clinically platinum resistant disease (relapse < 6 months after first course of chemotherapy). There was evidence of cisplatin resistance in 31 patients from their first ATP-TCA. Response to treatment was assessed by radiology, clinical assessment and tumor marker level (CA 125). RESULTS: The overall response rate was 59% (33/56) per course of chemotherapy, including 12 complete responses, 21 partial responses, 6 with stable disease, and 15 with progressive disease. Two patients were not evaluable for response having received just one cycle of chemotherapy: if these were excluded the response rate is 61%. Fifteen patients are still alive. Median progression free survival (PFS) was 6.6 months per course of chemotherapy; median overall survival (OAS) for each patient following the start of TCA-directed therapy was 10.4 months (95% confidence interval 7.9-12.8 months). CONCLUSION: The results show similar response rates to previous studies using ATP-TCA directed therapy in recurrent ovarian cancer. The assay shows high evaluability and this study adds weight to the reproducibility of results from different centre

Conformational Dynamics of Intrinsically Disordered Proteins Regulate Biomolecular Condensate Chemistry

Motions in biomolecules are critical for biochemical reactions. In cells, many biochemical reactions are executed inside of biomolecular condensates formed by ultradynamic intrinsically disordered proteins. A deep understanding of the conformational dynamics of intrinsically disordered proteins in biomolecular condensates is therefore of utmost importance but is complicated by diverse obstacles. Here we review emerging data on the motions of intrinsically disordered proteins inside of liquidlike condensates. We discuss how liquid–liquid phase separation modulates internal motions across a wide range of time and length scales. We further highlight the importance of intermolecular interactions that not only drive liquid–liquid phase separation but appear as key determinants for changes in biomolecular motions and the aging of condensates in human diseases. The review provides a framework for future studies to reveal the conformational dynamics of intrinsically disordered proteins in the regulation of biomolecular condensate chemistry

The Role of Muslim Devotional Practices in the Reversal of Language Shift

Fishman’s 1991 scale for evaluating language vitality proposes a stage in language shift where exclusively the older generation takes part in ‘rituals’, ‘concerts’ and ‘songfests’ in the minority language. Once this generation dies away, according to the scale, these cultural practices disappear with them. Within certain Muslim youth communities in the UK counter examples exist where the younger generation leads the way in reviving, performing and extending the repertoire of this religio-cultural heritage. Although this emerging expanded repertoire of song and poetry is clearly multilingual in nature, recitation and performance of the community heritage languages, Urdu and Punjabi, feature strongly. What remains to discover is whether such increasing familiarity with poetic language and form can impact positively on reversing the language shift these communities are experiencing in their third and fourth generations. Although there is evidence (Ostler & Lintinger 2015) that singing and reciting in other minority language settings, secular and religious, are not infrequent pursuits of youth, it is argued in this article that an accompanying religious revival provides an important extra, galvanising, boost to the process of possible reversing language shift. It is suggested that available scales for evaluating language vitality are inadequate in the face of complex diasporic minority language settings