“El Turismo Rural como Modelo de Desarrollo Turístico y sus efectos ambientales en la Fundación María Cavalleri, Municipio de Matagalpa, Departamento de Matagalpa, durante el II Semestre 2009”

Se investigó el Turismo Rural como Modelo de Desarrollo Turístico y sus efectos ambientales en la Finca Agroecológica “Fundación María Cavalleri”, municipio de Matagalpa, departamento de Matagalpa, durante el II Semestre 2009. Con el propósito de analizar los efectos ambientales que genera el Turismo Rural en dicha finca. Las principales temáticas abordadas en esta investigación son: El Turismo Rural como Modelo de Desarrollo Turístico, Actividades de Turismo Rural en la Fundación María Cavalleri y Efectos que genera el Turismo Rural en el Medio Ambiente. Este estudio se realizó a través de entrevistas dirigidas a trabajadores de la Fundación María Cavalleri, giras de campo a la finca para la complementación y constatación de la información. Los aspectos más relevantes del estudio reflejan que El Turismo Rural se aplica como modelo de desarrollo turístico a rasgos generales en la Finca Agroecológica Fundación María Cavalleri, ya que se desarrolla en el medio rural debido a las condiciones físicas y geográficas de la misma. Por otro lado queda en manifiesto que el Turismo Rural crea conciencia turística en sus gestores y beneficiarios, así mismo innova en nuevas técnicas de producción sostenibles y, contribuye al rescate y conservación del Medio Ambient

Proteccion a la Salud en Chile, derecho real o aparente?

72 p.La salud es un tema de interés general presente en cada etapa de la vida de las personas, por esto, no solo la medicina se ha ocupado de ella, sino también el derecho, por medio de la creación de distintas Leyes tanto a nivel nacional como internacional, que permitan su protección. La salud es un derecho que requiere para subsistir, un sistema sanitario que garantice a todos por igual un oportuno y completo acceso a la salud. El Estado es el responsable de garantizar este derecho evitando su vulneración, estableciendo mecanismos de acción, en caso de existir una violación a este derecho fundamental. Nuestra Constitución, considera el Derecho a la Salud como un derecho fundamental, estableciéndolo así en el artículo 19 Nº 9. Se intentará definir la realidad de la salud en nuestro país y a nivel internacional, intentando plasmar las dificultades que presenta el Recurso de Protección en salud

Differential Tiam1/Rac1 activation in hippocampal and cortical neurons mediates differential spine shrinkage in response to oxygen/glucose deprivation.

Distinct neuronal populations show differential sensitivity to global ischemia, with hippocampal CA1 neurons showing greater vulnerability compared to cortical neurons. The mechanisms that underlie differential vulnerability are unclear, and we hypothesize that intrinsic differences in neuronal cell biology are involved. Dendritic spine morphology changes in response to ischemic insults in vivo, but cell type-specific differences and the molecular mechanisms leading to such morphologic changes are unexplored. To directly compare changes in spine size in response to oxygen/glucose deprivation (OGD) in cortical and hippocampal neurons, we used separate and equivalent cultures of each cell type. We show that cortical neurons exhibit significantly greater spine shrinkage compared to hippocampal neurons. Rac1 is a Rho-family GTPase that regulates the actin cytoskeleton and is involved in spine dynamics. We show that Rac1 and the Rac guanine nucleotide exchange factor (GEF) Tiam1 are differentially activated by OGD in hippocampal and cortical neurons. Hippocampal neurons express more Tiam1 than cortical neurons, and reducing Tiam1 expression in hippocampal neurons by shRNA enhances OGD-induced spine shrinkage. Tiam1 knockdown also reduces hippocampal neuronal vulnerability to OGD. This work defines fundamental differences in signalling pathways that regulate spine morphology in distinct neuronal populations that may have a role in the differential vulnerability to ischemia

Learning contract, co-operative and flipped learning as useful tools for studying metabolism

Es el Abstract de una comunicación a un congreso internacional sobre educaciónUndergraduate students in Biology identify Metabolic Biochemistry as a particularly difficult subject. This is due to the fact that students need to interconnect properly all the contents of its syllabus throughout their study of the subject in order to get a global insight of the complex regulatory features controlling metabolic pathways within the metabolic network under different physiologic and pathologic conditions, as well as metabolism as a whole. Due to these objective difficulties, a high percentage of our students face the study of this subject as a very hard task beyond their forces and capacities. This perception leads to high rates of premature dropout. In previous years, less than 40% of all the registered students attended the examinations of Metabolic Biochemistry (a subject in the second year of the Degree of Biology at our University). Even worse, less than 25% of our students passed the exams. From the academic year 2015/16 on, we are developing innovative teaching projects (PIE15-163 and PIE17-145, funded by University of Malaga) aimed to increase our student loyalty to the subject (and hence to increase their attendance to exams) and to help them to learn more effectively metabolism and its regulation. These innovative teaching projects are based on the use of several powerful tools: a learning contract and problem-based learning within the framework of group tasks promoting an actual collaborative learning in a flipped classroom. The present communication will show the implementation of the PIE15-163 and PIE17-145 projects and some results obtained from them.This work was supported by Malaga University funds granted to the educational innovation project PIE17-145. The attendance to the END2018 International Conference on Education and New Developments (June 2018, Budapest, Hungary) has received a grant from "I Plan Propio Integral de Docencia. Universidad de Málaga"]

Solar Coronal Loops Associated with Small-scale Mixed Polarity Surface Magnetic Fields

How and where are coronal loops rooted in the solar lower atmosphere? The details of the magnetic environment and its evolution at the footpoints of coronal loops are crucial to understanding the processes of mass and energy supply to the solar corona. To address the above question, we use high-resolution line-of-sight magnetic field data from the Imaging Magnetograph eXperiment instrument on the SUNRISE balloon-borne observatory and coronal observations from the Atmospheric Imaging Assembly onboard the Solar Dynamics Observatory of an emerging active region. We find that the coronal loops are often rooted at the locations with minor small-scale but persistent opposite-polarity magnetic elements very close to the larger dominant polarity. These opposite-polarity small-scale elements continually interact with the dominant polarity underlying the coronal loop through flux cancellation. At these locations we detect small inverse Y-shaped jets in chromospheric Ca II H images obtained from the SUNRISE Filter Imager during the flux cancellation. Our results indicate that magnetic flux cancellation and reconnection at the base of coronal loops due to mixed polarity fields might be a crucial feature for the supply of mass and energy into the corona.Comment: Published in the Astrophysical Journal Supplement Serie

Kinematics of Magnetic Bright Features in the Solar Photosphere

Convective flows are known as the prime means of transporting magnetic fields on the solar surface. Thus, small magnetic structures are good tracers of the turbulent flows. We study the migration and dispersal of magnetic bright features (MBFs) in intergranular areas observed at high spatial resolution with Sunrise/IMaX. We describe the flux dispersal of individual MBFs as a diffusion process whose parameters are computed for various areas in the quiet Sun and the vicinity of active regions from seeing-free data. We find that magnetic concentrations are best described as random walkers close to network areas (diffusion index, gamma=1.0), travelers with constant speeds over a supergranule (gamma=1.9-2.0), and decelerating movers in the vicinity of flux emergence and/or within active regions (gamma=1.4-1.5). The three types of regions host MBFs with mean diffusion coefficients of 130 km^2/s, 80-90 km^2/s, and 25-70 km^2/s, respectively. The MBFs in these three types of regions are found to display a distinct kinematic behavior at a confidence level in excess of 95%.Comment: 8 pages, 4 figure

Morphological properties of slender Ca II H fibrils observed by SUNRISE II

We use seeing-free high spatial resolution Ca II H data obtained by the SUNRISE observatory to determine properties of slender fibrils in the lower solar chromosphere. In this work we use intensity images taken with the SUFI instrument in the Ca II H line during the second scientific flight of the SUNRISE observatory to identify and track elongated bright structures. After the identification, we analyze theses structures in order to extract their morphological properties. We identify 598 slender Ca II H fibrils (SCFs) with an average width of around 180 km, a length between 500 km and 4000 km, an average lifetime of ~400 s, and an average curvature of 0.002 arcsec^-1. The maximum lifetime of the SCFs within our time series of 57 minutes is ~2000 s. We discuss similarities and differences of the SCFs with other small-scale, chromospheric structures such as spicules of type I and II, or Ca II K fibrils.Comment: Accepted for publication in The Astrophysical Journal Supplement Serie

Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice

The present study was designed to investigate the effect of pharmacological inhibition of endocannabinoid degradation on behavioural actions of the dopamine D2/D3 receptor agonist quinpirole in male C57Bl/6J mice. In addition, we studied the effects of endocannabinoid degradation inhibition on both cocaine-induced psychomotor activation and behavioural sensitization. We analysed the effects of inhibition of the two main endocannabinoid degradation enzymes: fatty acid amide hydrolase (FAAH), using inhibitor URB597 (1 mg/kg); monoacylglycerol lipase (MAGL), using inhibitor URB602 (10 mg/kg). Administration of quinpirole (1 mg/kg) caused a temporal biphasic response characterized by a first phase of immobility (0–50 min), followed by enhanced locomotion (next 70 min) that was associated with the introduction of stereotyped behaviours (stereotyped jumping and rearing). Pretreatment with both endocannabinoid degradation inhibitors did not affect the hypoactivity actions of quinpirole. However, this pretreatment resulted in a marked decrease in quinpirole-induced locomotion and stereotyped behaviours. Administration of FAAH or MAGL inhibitors did not attenuate the acute effects of cocaine. Furthermore, these inhibitors did not impair the acquisition of cocaine-induced behavioural sensitization or the expression of cocaine-induced conditioned locomotion. Only MAGL inhibition attenuated the expression of an already acquired cocaine-induced behavioural sensitization. These results suggest that pharmacological inhibition of endocannabinoid degradation might exert a negative feedback on D2/D3 receptor-mediated hyperactivity. This finding might be relevant for therapeutic approaches for either psychomotor disorders (dyskinesia, corea) or disorganized behaviours associated with dopamine-mediated hyperactivity.Fil: Luque Rojas, María Jesús. Fundación IMABIS; EspañaFil: Galeano, Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Suarez, Juan . Fundación IMABIS; EspañaFil: Araos, Pedro. Fundación IMABIS; EspañaFil: Santín Nuñez, Luis Javier. Universidad de Malaga; EspañaFil: Rodríguez de Fonseca, Fernando. Fundación IMABIS; EspañaFil: Blanco Calvo, Eduardo. Fundación IMABIS; España. Universidad de Malaga; Españ

Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure

Systemic Lupus Erythematosus (SLE) is an autoimmune disease with a very varied spectrum of clinical manifestations that could be partly determined by genetic factors. We aimed to determine the relationship between prevalence of 11 clinical features and age of disease onset with European population genetic substructure. Data from 1413 patients of European ancestry recruited in nine countries was tested for association with genotypes of top ancestry informative markers. This analysis was done with logistic regression between phenotypes and genotypes or principal components extracted from them. We used a genetic additive model and adjusted for gender and disease duration. Three clinical features showed association with ancestry informative markers: autoantibody production defined as immunologic disorder (P = 6.8×10(-4)), oral ulcers (P = 6.9×10(-4)) and photosensitivity (P = 0.002). Immunologic disorder was associated with genotypes more common in Southern European ancestries, whereas the opposite trend was observed for photosensitivity. Oral ulcers were specifically more common in patients of Spanish and Portuguese self-reported ancestry. These results should be taken into account in future research and suggest new hypotheses and possible underlying mechanisms to be investigated. A first hypothesis linking photosensitivity with variation in skin pigmentation is suggested

O papel do juiz de garantias no debate de medidas cautelares pessoais. Revisão normativa dos sistemas processuais penais do Chile, Uruguai e Argentina federal

The functions that guarantee or control courts must fulfill in adversarial accusatory models are crucial for the proper protection of the rights and guarantees of all participants, especially the defendant and the accused. These functions are critical to the debates regarding the appropriateness of personal precautionary measures and require the judge to strictly observe the principles governing such measures and to justify how these principles are applied in each case. Supervisory courts must define and clearly state the standards required for each type of personal precautionary measure requested by the litigants and must reproduce in their rulings the criteria employed and the reasoning used to either confirm or dismiss the requirements of the personal precautionary measures, such as their material prerequisites and the necessity for caution.Las funciones que los tribunales de garantía o de control deben cumplir en los modelos acusatorios de corte adversarial son fundamentales para la debida protección de los derechos y las garantías de todos los intervinientes, en especial del imputado y el acusado. Estas funciones resultan críticas para los debates en torno a la procedencia de las medidas cautelares personales y suponen por parte del juez la estricta observancia de los principios que regulan tales medidas y la fundamentación acerca del modo en que estos principios son aplicados en cada caso. Los tribunales de garantía deben definir y explicitar los estándares exigibles para cada tipo de medida cautelar personal solicitada por los litigantes, y reproducir en sus resoluciones los criterios empleados y los fundamentos utilizados para dar por acreditados o desestimados los requisitos de las medidas cautelares personales, como son los presupuestos materiales de estas y la necesidad de cautela.As funções que os tribunais de garantias ou de controle devem cumprir nos modelos acusatórios de corte adversarial são fundamentais para a devida proteção dos direitos e garantias dos intervenientes, especialmente do imputado e do acusado. Essas funções são críticas para os debates sobre a procedência das medidas cautelares pessoais e implicam, por parte do juiz, a estrita observância dos princípios que regulam tais medidas e a fundamentação sobre a maneira como esses princípios são aplicados em cada caso. Os tribunais de garantia devem definir e explicitar os padrões exigíveis para cada tipo de medida cautelar pessoal solicitada pelos litigantes, e reproduzir em suas resoluções os critérios empregados e os fundamentos utilizados para considerar comprovados ou rejeitados os requisitos das medidas cautelares pessoais, como são os pressupostos materiais dessas medidas e a necessidade de cautela