Light during darkness and cancer: relationships in circadian photoreception and tumor biology

The relationship between circadian phototransduction and circadian-regulated processes is poorly understood. Melatonin, commonly a circadian phase marker, may play a direct role in a myriad of physiologic processes. The circadian rhythm for pineal melatonin secretion is regulated by the hypothalamic suprachiasmatic nucleus (SCN). Its neural source of light input is a unique subset of intrinsically photosensitive retinal ganglion cells expressing melanopsin, the primary circadian photopigment in rodents and primates. Action spectra of melatonin suppression by light have shown that light in the 446–477 nm range, distinct from the visual system’s peak sensitivity, is optimal for stimulating the human circadian system. Breast cancer is the oncological disease entity whose relationship to circadian rhythm fluctuations has perhaps been most extensively studied. Empirical data has increasingly supported the hypothesis that higher risk of breast cancer in industrialized countries is partly due to increased exposure to light at night. Studies of tumor biology implicate melatonin as a potential mediator of this effect. Yet, causality between lifestyle factors and circadian tumor biology remains elusive and likely reflects significant variability with physiologic context. Continued rigorous empirical inquiry into the physiology and clinical implications of these habitual, integrated aspects of life is highly warranted at this time

The Conchoid

The purpose of this thesis is to present 1n a simple and compact manner the conchoid, and to show its use in solving certain mathematical problems. Some of the better known curves related to the conchoid will also be discussed

The 3-dimensional Fourier grid Hamiltonian method

A method to compute the bound state eigenvalues and eigenfunctions of a Schr\"{o}dinger equation or a spinless Salpeter equation with central interaction is presented. This method is the generalization to the three-dimensional case of the Fourier grid Hamiltonian method for one-dimensional Schr\"{o}dinger equation. It requires only the evaluation of the potential at equally spaced grid points and yields the radial part of the eigenfunctions at the same grid points. It can be easily extended to the case of coupled channel equations and to the case of non-local interactions.Comment: 13 pages, 1 figure. RevTeX file. To appear in J. Comput. Phy

RDM Compas: Building Competencies for the Professional Curation of Research Data

“RDM Compas: Research Data Management Competence Base”, consisting of an education and training centre with modular online trainings on the one hand, and a comprehensive knowledge base covering all topics of curation-specific RDM on the other hand. In addition, a certification option is envisioned for curation-specific RDM competencies. In the context of our presentation, due to the advanced state of work we want to focus on the knowledge base and present its structure and elements. The structural basis is a slightly simplified version of the Data Curation Lifecycle Model [2] offered by the UK Digital Curation Centre [3]. This lifecycle describes both the basic activities and the sequential process steps of data curation and therefore provides a helpful schema for teaching the necessary RDM competencies

A mass formula for light mesons from a potential model

The quark dynamics inside light mesons, except pseudoscalar ones, can be quite well described by a spinless Salpeter equation supplemented by a Cornell interaction (possibly partly vector, partly scalar). A mass formula for these mesons can then be obtained by computing analytical approximations of the eigenvalues of the equation. We show that such a formula can be derived by combining the results of two methods: the dominantly orbital state description and the Bohr-Sommerfeld quantization approach. The predictions of the mass formula are compared with accurate solutions of the spinless Salpeter equation computed with a Lagrange-mesh calculation method.Comment: 5 figure

Dynamically generated open charmed baryons beyond the zero range approximation

The interaction of the low lying pseudo-scalar mesons with the ground state baryons in the charm sector is studied within a coupled channel approach using a t-channel vector-exchange driving force. The amplitudes describing the scattering of the pseudo-scalar mesons off the ground-state baryons are obtained by solving the Lippmann--Schwinger equation. We analyze in detail the effects of going beyond the $t=0$ approximation. Our model predicts the dynamical generation of several open charmed baryon resonances in different isospin and strangeness channels, some of which can be clearly identified with recently observed states.Comment: 7 figures, 8 table

Designing an information architecture for data management technologies: Introducing the DIAMANT model

Although research institutions take on increased responsibility for providing infrastructures and services around the proper handling of research data, there is no comprehensive framework addressing the ideal conditions of this implementation process. To overcome this gap, we present the DIAMANT model, a reference model aimed at providing an orientation framework for the implementation of research data management guided by the research process itself. It builds upon a central research data management information unit controlling the information flow between all other organizational units involved in research data management. Due to the possibility of outsourcing organizational units, the implementation process is maximally flexible and efficient

Wirkungsweise chemischer Nachbehandlungsmittel

Die Nachbehandlung von Beton mit flüssigen (chemischen) Nachbehandlungsmitteln stellt in vielen Fällen eine Alternative zu klassischen Nachbehandlungsarten,wie das Abdecken mit Folie oder das Auflegen von wasserspeichernden Abdeckungen,dar. Hierzu kommen Nachbehandlungsmittel unterschiedlicher chemi-scher Zusammensetzung zum Einsatz, die alle nach dem Auftrageneinen Film bilden, der die Wasserabgabe des Betons reduziert. Je nach Anwendungsgebiet werden unterschiedliche Nachbehandlungsmittel einge-setzt; im Betonstraßenbau sind Nachbehandlungsmittel auf der Basis von Paraffinwachsemulsionenam ver-breitetsten,wogegen bei Estrichen und Industrieböden häufiger Polymerdispersionen eingesetzt werden. Bei allen Nachbehandlungsmitteln ist die richtige Applikationentscheidendfür eine wirksame Nachbehandlung, insbesondere deroptimaleAuftragszeitpunkt spielt dabei eineentscheidende Rolle. Dieser Artikel erläutert die verschiedenen Arten von Nachbehandlungsmitteln, ihre Wirkungsweise sowie Einflüsse auf diese