45 research outputs found

    Higher order conductivity corrections to the Casimir force

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    The finite conductivity corrections to the Casimir force in two configurations are calculated in the third and fourth orders in relative penetration depth of electromagnetic zero oscillations into the metal. The obtained analytical perturbation results are compared with recent computations. Applications to the modern experiments are discussed.Comment: 15 pages, 4 figure

    Phosphodiesterase 4 Inhibition affects both the direct and indirect pathway : an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

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    Fronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Based on the overall expression in human fronto-striatal circuitry, we tested the effects of a cAMP selective phosphodiesterase 4 (PDE4) inhibitor on the tri-phasic response in the dorsomedial substantia nigra pars reticulata (SNr) upon stimulation of the infralimbic cortex in rats. Our results show for the first time that stimulation of the cognitive infralimbic cortex leads to a tri-phasic response in SNr neurons. In addition and in line with previous biochemical and behavioral studies, PDE4 inhibition by roflumilast affects the direct pathway as well as the indirect pathway of which the latter appears more sensitive than the former.Publisher PDFPeer reviewe

    Development and validation of a new asphalt mixture to reduce tyre-road contact noise in interurban areas

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    Road transport is one of the most important sources of noise emissions having a serious impact on human health. Thus, the objective of this study is to develop an innovative asphalt mixture that decreases noise from tyre and pavement interaction on highways with average speeds of about 80 km/h. To achieve this, a series of mechanical and functional tests were conducted both in the laboratory and at the Gustave Eiffel University Accelerated Pavement Testing (APT) facility. The new experimental mixture achieves a balance between high void content and low macro-texture (wavelengths of 5-50 mm), which improves noise reduction while maintaining good mechanical performance. This is achieved thanks to its two-layer structure, with a top layer of reduced maximum aggregate size (4 mm) and a thickness suitable for optimum sound absorption. Various mechanical tests, including the particle loss test and the water sensitivity test, along with functional evaluations focusing on texture, flow resistivity and sound absorption properties, were performed. Measurements on the APT were taken at three different stages of the pavement service lifetime during the testing phase. The outcome was the pro duction of an asphalt mixture that reduced noise up to 6.8 dB in comparison to an asphalt concrete road.This project has received funding from the European Union's Horizon 2020 Research and Innovation Programme under the Grant Agreement nº860441. PRE2020-093516 assistance financed by MICIU/AEI/10.13039/501100011033 and FSE “FSE invests in your future

    Morphology and origin of the Fair Oaks Dunes in NW Indiana, USA

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    The surficial geology of the Delta 7.5-minute series quadrangle, Fulton County, Ohio, USA

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    <p>The surficial geology of the Delta 7.5-minute series quadrangle, and sections of the adjacent quadrangles (ca. 54.5 km<sup>2</sup>), was mapped to elucidate the deglacial history of the Huron–Erie Lake Plain in northwest Ohio. Five depositional environments were identified: alluvial, aeolian, glacial, glaciolacustrine and glaciofluvial. The depositional environments were mapped on a hillshaded, light detecting and ranging digital elevation model using a sediment-landform approach. Map interpretations were field tested with borings, shallow pits, electrical resistivity and ground-penetrating radar surveys. Four prominent strandlines of Ancestral Lake Erie trend NNE to SSW across the study area at 238, 231, 224 and 221 m above sea level and are comprised of offshore bars, possible beaches and spits recording littoral drift from the NNE. This study emphasizes the importance of large-scale mapping and provides a framework for subsequent research in the region.</p

    Phosphodiesterase 4 Inhibition affects both the direct and indirect pathway:an electrophysiological study examining the tri-phasic response in the substantia nigra pars reticulata

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    Fronto-striatal circuits constitute the neurobiological basis of many neuropsychiatric disorders. Part of the intracellular signaling within these circuits, including its dopaminergic modulation, is regulated by the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA) signaling cascade. Based on the overall expression in human fronto-striatal circuitry, we tested the effects of a cAMP selective phosphodiesterase 4 (PDE4) inhibitor on the tri-phasic response in the dorsomedial substantia nigra pars reticulata (SNr) upon stimulation of the infralimbic cortex in rats. Our results show for the first time that stimulation of the cognitive infralimbic cortex leads to a tri-phasic response in SNr neurons. In addition and in line with previous biochemical and behavioral studies, PDE4 inhibition by roflumilast affects the direct pathway as well as the indirect pathway of which the latter appears more sensitive than the former
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