Homocysteine levels and treatment effect in the prospective study of pravastatin in the elderly at risk

Objectives: To assess the effect of preventive pravastatin treatment on coronary heart disease (CHD) morbidity and mortality in older persons at risk for cardiovascular disease (CVD), stratified according to plasma levels of homocysteine.<p></p> Design: A post hoc subanalysis in the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER), started in 1997, which is a double-blind, randomized, placebo-controlled trial with a mean follow-up of 3.2 years.<p></p> Setting: Primary care setting in two of the three PROSPER study sites (Netherlands and Scotland).<p></p> Participants: Individuals (n = 3,522, aged 70–82, 1,765 male) with a history of or risk factors for CVD were ranked in three groups depending on baseline homocysteine level, sex, and study site.<p></p> Intervention: Pravastatin (40 mg) versus placebo.<p></p> Measurements: Fatal and nonfatal CHD and mortality.<p></p> Results: In the placebo group, participants with a high homocysteine level (n = 588) had a 1.8 higher risk (95% confidence interval (CI) = 1.2–2.5, P = .001) of fatal and nonfatal CHD than those with a low homocysteine level (n = 597). The absolute risk reduction in fatal and nonfatal CHD with pravastatin treatment was 1.6% (95% CI = −1.6 to 4.7%) in the low homocysteine group and 6.7% (95% CI = 2.7–10.7%) in the high homocysteine group (difference 5.2%, 95% CI = 0.11–10.3, P = .046). Therefore, the number needed to treat (NNT) with pravastatin for 3.2 years for benefit related to fatal and nonfatal CHD events was 14.8 (95% CI = 9.3–36.6) for high homocysteine and 64.5 (95% CI = 21.4–∞) for low homocysteine.<p></p> Conclusion: In older persons at risk of CVD, those with high homocysteine are at highest risk for fatal and nonfatal CHD. With pravastatin treatment, this group has the highest absolute risk reduction and the lowest NNT to prevent fatal and nonfatal CHD.<p></p&gt

'Ladies and gentlemen, hats off, please!' : Dutch film lecturing and the case of Cor Schuring

Aux Pays-Bas, on appelait le bonimenteur de film l'explicateur et il a été présent dans les salles de cinéma jusqu 'à l'arrivée du cinéma sonore. Cet article tente de retrouver cet artiste de l'oral, et par là même insaisissable, à travers quelques traces des trait caractéristiques de son róle et de son statut. Il est illustré par une étude de cas sur un explicateur néerlandais, Cor Schuring, basée principalement sur des entretiens avec son fils et sur un album de coupures de presse. Schuring venait des variétés et du théâtre, et ce parcours, typiquement néerlandais, était celui de bien d'autres explicateurs. L'exemple de Schuring montre le róle politique de ce dernier dans le commerce du cinéma et fait ressortir la demande explicite de flexibilité sociale et d'adaptation dans la gestion des techniques de commentaire

Theory of anomalous magnetic interference pattern in mesoscopic SNS Josephson junctions

The magnetic interference pattern in mesoscopic SNS Josephson junctions is sensitive to the scattering in the normal part of the system. In this paper we investigate it, generalizing Ishii's formula for current-phase dependence to the case of normal scattering at NS boundaries in an SNS junction of finite width. The resulting flattening of the first diffraction peak is consistent with experimental data for S-2DEG-S mesoscopic junctions.Comment: 6 pages, 5 figures. Phys. Rev. B 68, 144514 (2003

ENVISAT tropical validation of cloud and ozone parameters by high-altitude aircraft.

The validation of cloud top and ozone vertical column, measured by SCIAMACHY, were carried out respectively by lidars and in-situ and remote-sensing ozone instruments on-board the high altitude Geophysica aircraft. Cloud top and ozone measurements were conducted during the transfer flights of the Geophysica from Europe to Brazil and in the Tropics, from Araçatuba, from January to the end of February 2005. The Validation campaign, financed by ESA, was embedded within a scientific campaign in the frame of two EC projects: APE-INFRA and Troccinox. Validation of MIPAS-ENVISAT products were planned by means of the corresponding instrument MIPAS-STR which was also on-board the Geophysica, and by means of other in-situ instruments. Some results of MIPAS-STR are reported here; however, the MIPAS data from the ENVISAT are not available. In general the validations show some discrepancies between the data collected by the Geophysica and the instruments on board of ENVISAT, which cannot easily be explained by the displacement of the satellite and aircraft measurements

Frontal plane pelvic motion during gait captures hip osteoarthritis related disability

Gait analysis has widely been accepted as an objective measure of function and clinical outcome. Ambulatory accelerometer-based gait analysis has emerged as a clinically more feasible alternative to optical motion capture systems but does not provide kinematic characterisation to identify disease dependent mechanisms causing walking disability. This study investigated the potential of a single inertial sensor to derive frontal plane motion of the pelvis (i.e. pelvic obliquity) and help identify hip osteoarthritis (OA) related gait alterations. Patients with advanced unilateral hip OA (n = 20) were compared to patients with advanced unilateral knee OA (n = 20) and to a healthy control group (n = 20). Kinematic characterisation of frontal plane pelvic motion during gait demonstrated decreased range of motion and increased asymmetry for hip OA patients specifically. </jats:p

Free-electron Model for Mesoscopic Force Fluctuations in Nanowires

When two metal electrodes are separated, a nanometer sized wire (nanowire) is formed just before the contact breaks. The electrical conduction measured during this retraction process shows signs of quantized conductance in units of G_0=2e^2/h. Recent experiments show that the force acting on the wire during separation fluctuates, which has been interpreted as being due to atomic rearrangements. In this report we use a simple free electron model, for two simple geometries, and show that the electronic contribution to the force fluctuations is comparable to the experimentally found values, about 2 nN.Comment: 4 pages, 3 figures, reference correcte

A luminosity constraint on the origin of unidentified high energy sources

The identification of point sources poses a great challenge for the high energy community. We present a new approach to evaluate the likelihood of a set of sources being a Galactic population based on the simple assumption that galaxies similar to the Milky Way host comparable populations of gamma-ray emitters. We propose a luminosity constraint on Galactic source populations which complements existing approaches by constraining the abundance and spatial distribution of any objects of Galactic origin, rather than focusing on the properties of a specific candidate emitter. We use M31 as a proxy for the Milky Way, and demonstrate this technique by applying it to the unidentified EGRET sources. We find that it is highly improbable that the majority of the unidentified EGRET sources are members of a Galactic halo population (e.g., dark matter subhalos), but that current observations do not provide any constraints on all of these sources being Galactic objects if they reside entirely in the disk and bulge. Applying this method to upcoming observations by the Fermi Gamma-ray Space Telescope has the potential to exclude association of an even larger number of unidentified sources with any Galactic source class.Comment: 18 pages, 4 figures, to appear in JPhys

Universality in metallic nanocohesion: a quantum chaos approach

Convergent semiclassical trace formulae for the density of states and cohesive force of a narrow constriction in an electron gas, whose classical motion is either chaotic or integrable, are derived. It is shown that mode quantization in a metallic point contact or nanowire leads to universal oscillations in its cohesive force: the amplitude of the oscillations depends only on a dimensionless quantum parameter describing the crossover from chaotic to integrable motion, and is of order 1 nano-Newton, in agreement with recent experiments. Interestingly, quantum tunneling is shown to be described quantitatively in terms of the instability of the classical periodic orbits.Comment: corrects spelling of one author name on abstract page (paper is unchanged

Charge and Spin Effects in Mesoscopic Josephson Junctions

We consider the charge and spin effects in low dimensional superconducting weak links. The first part of the review deals with the effects of electron-electron interaction in Superconductor/Luttinger liquid/Superconductor junctions. The experimental realization of this mesoscopic hybrid system can be the individual single wall carbon nanotube that bridges the gap between two bulk superconductors. The dc Josephson current through a Luttinger liquid in the limits of perfectly and poorly transmitting junctions is evaluated. The relationship between the Josephson effect in a long SNS junction and the Casimir effect is discussed. In the second part of the paper we review the recent results concerning the influence of the Zeeman and Rashba interactions on the thermodynamical properties of ballistic S/QW/S junction fabricated in two dimensional electron gas. It is shown that in magnetically controlled junction there are conditions for resonant Cooper pair transition which results in giant supercurrent through a tunnel junction and a giant magnetic response of a multichannel SNS junction. The supercurrent induced by the joint action of the Zeeman and Rashba interactions in 1D quantum wires connected to bulk superconductors is predicted.Comment: 36 pages, 8 figures; minor changes in reference