Spectral Efficiency Optimization in Flexi-Grid Long-Haul Optical Systems

Flexible grid optical networks allow a better exploitation of fiber capacity, by enabling a denser frequency allocation. A tighter channel spacing, however, requires narrower filters, which increase linear intersymbol interference (ISI), and may dramatically reduce system reach. Commercial coherent receivers are based on symbol by symbol detectors, which are quite sensitive to ISI. In this context, Nyquist spacing is considered as the ultimate limit to wavelength-division multiplexing (WDM) packing. In this paper, we show that by introducing a limited-complexity trellis processing at the receiver, either the reach of Nyquist WDM flexi-grid networks can be significantly extended, or a denser-than-Nyquist channel packing (i.e., a higher spectral efficiency (SE)) is possible at equal reach. By adopting well-known information-theoretic techniques, we design a limited-complexity trellis processing and quantify its SE gain in flexi-grid architectures where wavelength selective switches over a frequency grid of 12.5GHz are employed.Comment: 7 pages, 9 figure

Custom Dual Transportation Mode Detection by Smartphone Devices Exploiting Sensor Diversity

Making applications aware of the mobility experienced by the user can open the door to a wide range of novel services in different use-cases, from smart parking to vehicular traffic monitoring. In the literature, there are many different studies demonstrating the theoretical possibility of performing Transportation Mode Detection (TMD) by mining smart-phones embedded sensors data. However, very few of them provide details on the benchmarking process and on how to implement the detection process in practice. In this study, we provide guidelines and fundamental results that can be useful for both researcher and practitioners aiming at implementing a working TMD system. These guidelines consist of three main contributions. First, we detail the construction of a training dataset, gathered by heterogeneous users and including five different transportation modes; the dataset is made available to the research community as reference benchmark. Second, we provide an in-depth analysis of the sensor-relevance for the case of Dual TDM, which is required by most of mobility-aware applications. Third, we investigate the possibility to perform TMD of unknown users/instances not present in the training set and we compare with state-of-the-art Android APIs for activity recognition.Comment: Pre-print of the accepted version for the 14th Workshop on Context and Activity Modeling and Recognition (IEEE COMOREA 2018), Athens, Greece, March 19-23, 201

Prognostic significance of primary-tumor extension, stage and grade of nuclear differentiation in patients with renal cell carcinoma

Surgery remains the preferred therapy for renal cell carcinoma. The various adjunctive or complementary therapies currently yield disappointing results. Identifying reliable prognostic factors could help in selecting patients most likely to benefit from postoperative adjuvant therapies. We reviewed the surgical records of 78 patients who had undergone radical nephrectomy with lymphadenectomy for renal cell carcinoma, matched for type of operation and histology. According to staging (TNM), 5.1% of the patients were classified as stage I, 51.3% as stage II, 29.5% as stage III and 14.5% as stage IV. Of the 78 patients 40 were T2N0 and 21 T3aN0. Tumor grading showed that 39.7% of the patients had well-differentiated tumors(G1), 41.1% moderately-differentiated (G2), and 19.2% poorly-differentiated tumors (G3). Overall actuarial survival at 5 and 10 years was 100% for stage 1; 91.3% at 5 years and 83.1% at 10 years for stage II; 45.5% and 34.1% for stage III; and 29.1% and nil for stage IV (stage II vs stage III p = 0.0001). Patients with tumors confined to the kidney (pT2N0) had better 5- and 10-year survival rates than patients with tumors infiltrating the perirenal fat (pT3aN0) (p = 0.000006). Survival differed according to nuclear grading (G1 vs G3 ; p = 0.000005; G2 vs G3; p = 0.0009). In conclusion our review identified tumor stage, primary-tumor extension, and the grade of nuclear differentiation as reliable prognostic factors in patients with renal cell carcinomas

Pediatric cervicofacial actinomycosis: Case report and review of the literature

Objective: To emphasize important features in the diagnosis and monitoring of patients with childhood cervical actinomycosis. Subject and methods: This study is a case report about the occurrence of actinomycosis in cervicofacial form. We conducted literature review of the last years by means of the Lilacs and Medline databases. Results: A male patient was monitored in an infirmary of pediatric infectious diseases. The diagnosis was made through cervical node biopsy and isolation of the bacteria. Specific penicillin for actinomycosis had been given to the patient for 14 days. After the node decreased, the patient was released but, at the same time, a prescription of amoxycillin, for the minimum of 6 months, was given to him with simultaneous ambulatorial monitoring. Conclusion: Early diagnosis of actinomycosis enables appropriate and prompt treatment, thus preventing the involvement of other areas such as CNS, face, and neck.Objetivo: Enfatizar aspectos importantes para o diagnóstico e manejo clínico de pacientes com actinomicose cervicofacial na infância. Casuística e método: O presente estudo é um relato de caso de actinomicose na forma cervicofacial, acompanhando de revisão da literatura dos últimos anos através dos bancos de dados Lilacs e Medline. Resultados: Paciente do sexo masculino acompanhado na enfermaria de moléstias infecciosas pediátricas por actinomicose cervicofacial. O diagnóstico foi realizado através de biópsia de nódulo cervical e isolamento da bactéria. O antibiótico utilizado foi a penicilina específica para o actimomices, por 14 dias. Alta após diminuição do nódulo, com orientação de amoxicilina por mínimo de 6 meses e acompanhamento ambulatorial. Conclusão: O diagnóstico precoce da actinomicose resulta em tratamento adequado e imediato, evitando-se o acometimento de áreas nobres em SNC, face e pescoço.UNIFESP-EPM Disciplina de Infectologia PediátricaUNIFESP-EPM Departamento de Pediatria Disciplina de Infectologia PediátricaUNIFESP-EPM Infectologia Pediátrica Curso de EspecializaçãoUNIFESP-EPM PediatriaUNIFESP-EPM Instituto de Oncologia PediátricaUNIFESP, EPM, Disciplina de Infectologia PediátricaUNIFESP, EPM Depto. de Pediatria Disciplina de Infectologia PediátricaUNIFESP, EPM Infectologia Pediátrica Curso de EspecializaçãoUNIFESP, EPM PediatriaUNIFESP, EPM Instituto de Oncologia PediátricaSciEL

Predictive value of hematological and phenotypical parameters on postchemotherapy leukocyte recovery

Background: Grade IV chemotherapy toxicity is defined as absolute neutrophil count <500/μL. The nadir is considered as the lowest neutrophil number following chemotherapy, and generally is not expected before the 7th day from the start of chemotherapy. The usual prophylactic dose of rHu-G-CSF (Filgrastim) is 300 μg/day, starting 24-48 h after chemotherapy until hematological recovery. However, individual patient response is largely variable, so that rHu-G-CSF doses can be different. The aim of this study was to verify if peripheral blood automated flow cytochemistry and flow cytometry analysis may be helpful in predicting the individual response and saving rHu-G-CSF. Methods: During Grade IV neutropenia, blood counts from 30 cancer patients were analyzed daily by ADVIA 120 automated flow cytochemistry analyzer and by Facscalibur flow cytometer till the nadir. "Large unstained cells" (LUCs), myeloperoxidase index (MPXI), blasts, and various cell subpopulations in the peripheral blood were studied. At nadir rHu-G-CSF was started and 81 chemotherapy cycles were analyzed. Cycles were stratified according to their number and to two dose-levels of rHuG-CSF needed to recovery (300-600 vs. 900-1200 μg) and analyzed in relation to mean values of MPXI and mean absolute number of LUCs in the nadir phase. The linear regressions of LUCs % over time in relation to two dose-levels of rHu-G-CSF and uni-multivariate analysis of lymphocyte subpopulations, CD34+ cells, MPXI, and blasts were also performed. Results: In the nadir phase, the increase of MPXI above the upper limit of normality (>10; median 27.7), characterized a slow hematological recovery. MPXI levels were directly related to the cycle number and inversely related to the absolute number of LUCs and CD34 +/CD45+ cells. A faster hematological recovery was associated with a higher LUC increase per day (0.56% vs. 0.25%), higher blast (median 36.7/μL vs. 19.5/μL) and CD34+/CD45+ cell (median 2.2/μL vs. 0.82/μL) counts. Conclusions: Our study showed that some biological indicators such as MPXI, LUCs, blasts, and CD34 +/CD45+ cells may be of clinical relevance in predicting individual hematological response to rHu-G-CSF. Special attention should be paid when nadir MPXI exceeds the upper limit of normality because the hematological recovery may be delayed. © 2009 Clinical Cytometry Society

Paralog-Specific Patterns of Structural Disorder and Phosphorylation in the Vertebrate SH3–SH2–Tyrosine Kinase Protein Family

One of the largest multigene families in Metazoa are the tyrosine kinases (TKs). These are important multifunctional proteins that have evolved as dynamic switches that perform tyrosine phosphorylation and other noncatalytic activities regulated by various allosteric mechanisms. TKs interact with each other and with other molecules, ultimately activating and inhibiting different signaling pathways. TKs are implicated in cancer and almost 30 FDA-approved TK inhibitors are available. However, specific binding is a challenge when targeting an active site that has been conserved in multiple protein paralogs for millions of years. A cassette domain (CD) containing SH3–SH2–Tyrosine Kinase domains reoccurs in vertebrate nonreceptor TKs. Although part of the CD function is shared between TKs, it also presents TK specific features. Here, the evolutionary dynamics of sequence, structure, and phosphorylation across the CD in 17 TK paralogs have been investigated in a large-scale study. We establish that TKs often have ortholog-specific structural disorder and phosphorylation patterns, while secondary structure elements, as expected, are highly conserved. Further, domain-specific differences are at play. Notably, we found the catalytic domain to fluctuate more in certain secondary structure elements than the regulatory domains. By elucidating how different properties evolve after gene duplications and which properties are specifically conserved within orthologs, the mechanistic understanding of protein evolution is enriched and regions supposedly critical for functional divergence across paralogs are highlighted