Realisations of W3W_3 Symmetry

We perform a systematic investigation of free-scalar realisations of the Za\-mo\-lod\-chi\-kov $W_3$ algebra in which the operator product of two spin-three generators contains a non-zero operator of spin four which has vanishing norm. This generalises earlier work where such an operator was required to be absent. By allowing this spin-four null operator we obtain several realisations of the $W_3$ algebra both in terms of two scalars as well as in terms of an arbitrary number $n$ of free scalars. Our analysis is complete for the case of two-scalar realisations.Comment: 14 pages, LATEX, UG-6/9

Validation of a smartphone app to map social networks of proximity

Social network analysis is a prominent approach to investigate interpersonal relationships. Most studies use self-report data to quantify the connections between participants and construct social networks. In recent years smartphones have been used as an alternative to map networks by assessing the proximity between participants based on Bluetooth and GPS data. While most studies have handed out specially programmed smartphones to study participants, we developed an application for iOS and Android to collect Bluetooth data from participants own smartphones. In this study, we compared the networks estimated with the smartphone app to those obtained from sociometric badges and self-report data. Participants (n=21) installed the app on their phone and wore a sociometric badge during office hours. Proximity data was collected for 4 weeks. A contingency table revealed a significant association between proximity data (rho = 0.17, p<0.0001), but the marginal odds were higher for the app (8.6%) than for the badges (1.3%), indicating that dyads were more often detected by the app. We then compared the networks that were estimated using the proximity and self-report data. All three networks were significantly correlated, although the correlation with self-reported data was lower for the app (rho = 0.25) than for badges (rho = 0.67). The scanning rates of the app varied considerably between devices and was lower on iOS than on Android. The association between the app and the badges increased when the network was estimated between participants whose app recorded more regularly. These findings suggest that the accuracy of proximity networks can be further improved by reducing missing data and restricting the interpersonal distance at which interactions are detected.Comment: 20 pages, 5 figure

Cofactor regeneration by a soluble pyridine nucleotide transhydrogenase for biological production of hydromorphone

We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug hydromorphone. The original recombinant whole-cell system suffered from cofactor depletion resulting from the action of an NADP(+)-dependent morphine dehydrogenase and an NADH-dependent morphinone reductase. By applying a soluble pyridine nucleotide transhydrogenase, which can transfer reducing equivalents between NAD and NADP, we demonstrate with a cell-free system that efficient cofactor cycling in the presence of catalytic amounts of cofactors occurs, resulting in high yields of hydromorphone. The ratio of morphine dehydrogenase, morphinone reductase, and soluble pyridine nucleotide transhydrogenase is critical for diminishing the production of the unwanted by-product dihydromorphine and for optimum hydromorphone yields. Application of the soluble pyridine nucleotide transhydrogenase to the whole-cell system resulted in an improved biocatalyst with an extended lifetime. These results demonstrate the usefulness of the soluble pyridine nucleotide transhydrogenase and its wider application as a tool in metabolic engineering and biocatalysis

Using Bluetooth Low Energy in smartphones to map social networks

Social networks have an important role in an individual's health, with the propagation of health-related features through a network, and correlations between network structures and symptomatology. Using Bluetooth-enabled smartphones to measure social connectivity is an alternative to traditional paper-based data collection; however studies employing this technology have been restricted to limited sets of homogenous handsets. We investigated the feasibility of using the Bluetooth Low Energy (BLE) protocol, present on users' own smartphones, to measure social connectivity. A custom application was designed for Android and iOS handsets. The app was configured to simultaneously broadcast via BLE and perform periodic discovery scans for other nearby devices. The app was installed on two Android handsets and two iOS handsets, and each combination of devices was tested in the foreground, background and locked states. Connectivity was successfully measured in all test cases, except between two iOS devices when both were in a locked state with their screens off. As smartphones are in a locked state for the majority of a day, this severely limits the ability to measure social connectivity on users' own smartphones. It is not currently feasible to use Bluetooth Low Energy to map social networks, due to the inability of iOS devices to detect another iOS device when both are in a locked state. While the technology was successfully implemented on Android devices, this represents a smaller market share of partially or fully compatible devices.Comment: 6 pages, 1 tabl

Non-extremal D-instantons

We construct the most general non-extremal deformation of the D-instanton solution with maximal rotational symmetry. The general non-supersymmetric solution carries electric charges of the SL(2,R) symmetry, which correspond to each of the three conjugacy classes of SL(2,R). Our calculations naturally generalise to arbitrary dimensions and arbitrary dilaton couplings. We show that for specific values of the dilaton coupling parameter, the non-extremal instanton solutions can be viewed as wormholes of non-extremal Reissner-Nordstr\"om black holes in one higher dimension. We extend this result by showing that for other values of the dilaton coupling parameter, the non-extremal instanton solutions can be uplifted to non-extremal non-dilatonic p-branes in p+1 dimensions higher. Finally, we attempt to consider the solutions as instantons of (compactified) type IIB superstring theory. In particular, we derive an elegant formula for the instanton action. We conjecture that the non-extremal D-instantons can contribute to the R^8-terms in the type IIB string effective action.Comment: 31 pages, 4 figures. v3: minor correction and reference adde

The holographic RG flow in a field theory on a curved background

As shown by Freedman, Gubser, Pilch and Warner, the RG flow in ${\cal N}=4$ super-Yang-Mills theory broken to an ${\cal N}=1$ theory by the addition of a mass term can be described in terms of a supersymmetric domain wall solution in five-dimensional ${\cal N}=8$ gauged supergravity. The FGPW flow is an example of a holographic RG flow in a field theory on a flat background. Here we put the field theory studied by Freedman, Gubser, Pilch and Warner on a curved $AdS_4$ background, and we construct the supersymmetric domain wall solution which describes the RG flow in this field theory. This solution is a curved (non Ricci flat) domain wall solution. This example demonstrates that holographic RG flows in supersymmetric field theories on a curved $AdS_4$ background can be described in terms of curved supersymmetric domain wall solutions.Comment: 14 pages, LaTe

Hydrodynamics from the Dp-brane

We complete the computation of viscous transport coefficients in the near horizon geometries that arise from a stack of black Dp-branes for p=2,...,6 in the decoupling limit. The main new result is the obtention of the bulk viscosity which, for all p, is found to be related to the speed of sound by the simple relation \zeta/\eta = -2(v_s^2-1/p). For completeness the shear viscosity is rederived from gravitational perturbations in the shear and scalar channels. We comment on technical issues like the counterterms needed, or the possible dependence on the conformal frame.Comment: 15 page

AdS Duals of Matrix Strings

We review recent work on the holographic duals of type II and heterotic matrix string theories described by warped AdS_3 supergravities. In particular, we compute the spectra of Kaluza-Klein primaries for type I, II supergravities on warped AdS_3xS^7 and match them with the primary operators in the dual two-dimensional gauge theories. The presence of non-trivial warp factors and dilaton profiles requires a modification of the familiar dictionary between masses and ``scaling'' dimensions of fields and operators. We present these modifications for the general case of domain wall/QFT correspondences between supergravities on warped AdS_{d+1}xS^q geometries and super Yang-Mills theories with 16 supercharges.Comment: 7 pages, Proceedings of the RTN workshop ``The quantum structure of spacetime and the geometric nature of fundamental interactions'', Leuven, September 200

Supercharges, Killing Spinors and Intersecting Gauge Five-branes

We obtain new solutions where a string and a pp-wave lie in the common worldvolume directions of the non-standard intersection of two gauge 5-branes in the heterotic string. The two 5-branes are supported by independent SU(2) Yang-Mills instantons in their respective (non-overlapping) transverse spaces. We present a detailed study of the unbroken supersymmetry, focusing especially on a comparison between a direct construction of Killing spinors and a counting of zero eigenvalues in the annticommutator of supercharges. The results are in agreement with some previous arguments, to the effect that additional zero eigenvalues resulting from a ``fine-tuning'' between positive-energy and negative-energy contributions from different components in an intersection are spurious, and should not be taken as an indication of supersymmetry enhancements. These observations have a general applicability that goes beyond the specific example we study in this paper.Comment: Latex, 23 pages; minor revisions, and references adde

Seven-branes and Supersymmetry

We re-investigate the construction of half-supersymmetric 7-brane solutions of IIB supergravity. Our method is based on the requirement of having globally well-defined Killing spinors and the inclusion of SL(2,Z)-invariant source terms. In addition to the well-known solutions going back to Greene, Shapere, Vafa and Yau we find new supersymmetric configurations, containing objects whose monodromies are not related to the monodromy of a D7-brane by an SL(2,Z) transformation.Comment: 31 pages, 3 figure