An investigation to assess ankle mobility in healthy individuals from the application of multi-component compression bandages and compression hosiery

Background An investigation was undertaken to compare the effect of multi-component compression bandages and compression hosiery kits on individuals’ range of ankle motion whilst wearing typical and medical footwear, and barefoot. Methods A convenience sample of 30 healthy individuals recruited from the staff and student population at the University of Huddersfield, UK. Plantarflexion/dorsiflexion range of ankle motion (ROAM) was measured in participants over 6 steps in every combination of typical, medical and no footwear; and multi-component bandages, compression hosiery and no garments. Results Controlling for age, gender and garments, the use of typical footwear was associated with a mean increase in ROAM of 2.54° at best estimate compared with barefoot; the use of medical footwear was associated with a mean decrease in ROAM of 1.12° at best estimate compared with barefoot. Controlling for age, gender and footwear, the use of bandaging was associated with a mean decrease in ROAM of 2.51° at best estimate compared with no garments. Controlling for age, gender and footwear, the use of hosiery was not associated with a significant change in ROAM compared with no garments. Conclusions Bandages appear to restrict ROAM more than hosiery when used in conjunction with a variety of footwear types

Resident Instruction in Social Emergency Medicine

Understanding social determinants of health (SDH) and their intersection with emergency medicine, also known as social emergency medicine (SEM), is an important area of EM training.https://knowledgeconnection.mainehealth.org/lambrew-retreat-2021/1043/thumbnail.jp

Undergraduate Students’ Perception of Leadership Development Programs and Leadership Self-Efficacy

Colleges and universities across the United States face continual pressure to meet enrollment and retention goals, as budgets in this performance-based environment continue to become more important. On-campus student involvement, such as in undergraduate leadership development programs, has been shown to have a positive influence on both student retention and success. A survey was utilized to examine leadership self-efficacy and engagement of undergraduate students that participated in campus-based leadership development programs and explore some motivators (contributing factors) and barriers (detracting factors) to involvement in those programs. One emergent theme within contributing factors to participation was alignment with personal goals (74.7%), whereas, a theme for detracting factors was lack of time to invest in the leadership opportunity (51.1%). Exploration of which factors contributed to and detracted from leadership development participation showed that contributing factors were a positive and significant predictor of leadership self-efficacy. For every one unit increase in contributing factors, leadership self-efficacy score increased by β - = .38 standard deviations. This study encourages leadership educators to examine their own leadership development programs and build recruitment strategies to increase engagement among student demographics such as male students, non-White students, and first-generation college students. In the future, researchers could consider including students that did not participate in leadership programs to gain more valuable insights on the motivators and the barriers that students face to participation in these programs

Novel cyclometalated iridium (III) complexes as antibacterial agents for photodynamic inactivation

Staphylococcus aureus and methicillin-resistant S. aureus (MRSA) frequently cause chronic skin and soft tissue infections and device-related infections. These bacteria colonize human skin and can survive for long periods within biofilms, on indwelling medical devices, high touch surfaces and equipment in the healthcare setting, which are reservoirs for further transmission to patients. Photodynamic therapy may offer an alternative to antibiotics in the management of infections or photodynamic disinfection may limit transmission of specific pathogens in the healthcare setting. Two novel cyclometalated iridium (III) complexes [Ir(ppy)2L](PF6) (ppy: phenyl pyridine, L = 6-((2,6-diisopropylphenyl)amino)-5,6-dihydro-1,10-phenanthrolin-5-ol (Ir1) and L = N-(2,6-diisopropylphenyl)-1,10-phenanthrolin-5-amine (Ir2)) were synthesized and evaluated for their antimicrobial properties when activated by light (370 nm). Iridium complexes (Ir1 and Ir2) led to potent inactivation of planktonic Staphylococcus aureus at 5 µM (almost 5 log10 reduction in colony forming units (CFU)/mL) after light exposure (p ≤ 0.01 for dark vs light). Dark toxicity was < 1 log10. Under the same conditions, Escherichia coli killing was < 1 log10. Anti-staphylococcal activity was concentration-dependant over the range 0.1 µM − 5 µM (p ≤ 0.001, Ir1, p ≤ 0.01 Ir2). Anti-biofilm activity was observed against mature (72 h) biofilms of S. aureus including methicillin-resistant S. aureus (MRSA) biofilms but higher concentrations (50 μM) were required. Treatment with Ir1 or Ir2 resulted in removal of 20 – 32 % of biofilm biomass as measured by crystal violet staining and 24 – 73 % reduction in the metabolic activity of cells within the biofilm, using resazurin reduction assays. Cytotoxicity to cultured human keratinocytes was minimal at antimicrobial concentrations but increased with higher concentrations, for Ir1 but not Ir2 (Ir1 p ≤ 0.01, 5 Vs 50 μM). The quantum yield for singlet oxygen (1O2) emission was measured as 0.16 and 0.30 for Ir1 and Ir2 respectively. Ground and excited state UV–Vis absorption, steady-state and time-resolved studies together with cyclic voltammetry are also presented. In summary, the potent and rapid antimicrobial activity of these cyclometalated iridium (III) complexes against S. aureus and MRSA, which included biofilm eradication, highlight their potential in the management or prevention of device-associated infections or healthcare transmission involving these pathogens

Genomic and clinical characterization of stromal infiltration markers in prostate cancer

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/154519/1/cncr32688_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/154519/2/cncr32688.pd

The Grizzly, September 4, 2003

A Space to Call Your Own • Pay for Print Solution • Bumpy Ride • Spotlight on Politics: The California Recall • Feeling Disconnected: Internet and Virus Woes • A Plan for Every Future: Career Services Fall 2003 • Opinions: Campus Rooms: Is Space Running Out?; Network Gripes Getting you Down? Elections in California: Business as Usual or Free for All? • Activities, Activities, Activities • Calling all Thespians! • Ursinus in 1893: What was it Like? • New Arts Center • Local Heritage Day Celebration • Bears Versatility Makes the Season Look Promising • UC Field Hockey Team: Ready to Rumble • Promising Season Abound for the Men and Women\u27s Soccer Teams • Ursinus Cross Country Kicks-off • Ursinus Volleyball Team Off to Rough Start • X-Country Team Scoreshttps://digitalcommons.ursinus.edu/grizzlynews/1539/thumbnail.jp

Search for top squark pair production using dilepton final states in pp collision data collected at root s=13TeV

A search is presented for supersymmetric partners of the top quark (top squarks) in final states with two oppositely charged leptons (electrons or muons), jets identified as originating from bquarks, and missing transverse momentum. The search uses data from proton-proton collisions at root s = 13 TeV collected with the CMS detector, corresponding to an integrated luminosity of 137 fb(-1). Hypothetical signal events are efficiently separated from the dominant top quark pair production background with requirements on the significance of the missing transverse momentum and on transverse mass variables. No significant deviation is observed from the expected background. Exclusion limits are set in the context of simplified supersymmetric models with pair-produced lightest top squarks. For top squarks decaying exclusively to a top quark and a lightest neutralino, lower limits are placed at 95% confidence level on the masses of the top squark and the neutralino up to 925 and 450 GeV, respectively. If the decay proceeds via an intermediate chargino, the corresponding lower limits on the mass of the lightest top squark are set up to 850 GeV for neutralino masses below 420 GeV. For top squarks undergoing a cascade decay through charginos and sleptons, the mass limits reach up to 1.4 TeV and 900 GeV respectively for the top squark and the lightest neutralino.Peer reviewe

Measurement of the t(t)over-barb(b)over-bar production cross section in the all-jet final state in pp collisions at root s=13 TeV

A measurement of the production cross section of top quark pairs in association with two b jets (t (t) over barb (b) over bar) is presented using data collected in proton-proton collisions at root s=13 TeV by the CMS detector at the LHC corresponding to an integrated luminosity of 35.9 fb(-1). The cross section is measured in the all-jet decay channel of the top quark pair by selecting events containing at least eight jets, of which at least two are identified as originating from the hadronization of b quarks. A combination of multivariate analysis techniques is used to reduce the large background from multijet events not containing a top quark pair, and to help discriminate between jets originating from top quark decays and other additional jets. The cross section is determined for the total phase space to be 5.5 +/- 0.3 (stat)(-1.3)(+)(1.6) (syst)pb and also measured for two fiducial t (t) over barb (b) over bar, definitions. The measured cross sections are found to be larger than theoretical predictions by a factor of 1.5-2.4, corresponding to 1-2 standard deviations. (C) 2020 The Author. Published by Elsevier B.V.Peer reviewe

Search for dark photons in Higgs boson production via vector boson fusion in proton-proton collisions at √s = 13 TeV

A search is presented for a Higgs boson that is produced via vector boson fusion and that decays to an undetected particle and an isolated photon. The search is performed by the CMS collaboration at the LHC, using a data set corresponding to an integrated luminosity of 130 fb−1, recorded at a center-of-mass energy of 13 TeV in 2016–2018. No significant excess of events above the expectation from the standard model background is found. The results are interpreted in the context of a theoretical model in which the undetected particle is a massless dark photon. An upper limit is set on the product of the cross section for production via vector boson fusion and the branching fraction for such a Higgs boson decay, as a function of the Higgs boson mass. For a Higgs boson mass of 125 GeV, assuming the standard model production rates, the observed (expected) 95% confidence level upper limit on the branching fraction is 3.5 (2.8)%. This is the first search for such decays in the vector boson fusion channel. Combination with a previous search for Higgs bosons produced in association with a Z boson results in an observed (expected) upper limit on the branching fraction of 2.9 (2.1)% at 95% confidence level

Search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at 13 TeV

Results are reported of a search for supersymmetry in final states with photons and missing transverse momentum in proton-proton collisions at the LHC. The data sample corresponds to an integrated luminosity of 35.9 fb collected at a center-of-mass energy of 13 TeV using the CMS detector. The results are interpreted in the context of models of gauge-mediated supersymmetry breaking. Production cross section limits are set on gluino and squark pair production in this framework. Gluino masses below 1.86 TeV and squark masses below 1.59 TeV are excluded at 95% confidence levelIndividuals have received support from the Marie-Curie program and the European Research Council and Horizon 2020 Grant, contract No. 675440 (European Union); the Leventis Foundation; the A.P. Sloan Foundation; the Alexander von Humboldt Foundation; the Belgian Federal Science Policy Office; the Fonds pour la Formation a la Recherche dans l’Industrie et dans l’Agriculture (FRIA-Belgium); the Agentschap voor Innovatie door Wetenschap en Technologie (IWT-Belgium); the F.R.S.-FNRS and FWO (Belgium) under the “Excellence of Science — EOS” — be.h project n. 30820817; the Ministry of Education, Youth and Sports (MEYS) of the Czech Republic; the Lendület (“Momentum”) Program and the J´anos Bolyai Research Scholarship of the Hungarian Academy of Sciences, the New National Excellence Program UNKP, the NKFIA research grants 123842, 123959, 124845, 124850 and 125105 (Hungary); the Council of Science and Industrial Research, India; the HOMING PLUS program of the Foundation for Polish Science, cofinanced from European Union, Regional Development Fund, the Mobility Plus program of the Ministry of Science and Higher Education, the National Science Center (Poland), contracts Harmonia 2014/14/M/ST2/00428, Opus 2014/13/B/ST2/02543, 2014/15/B/ST2/03998, and 2015/19/B/ST2/02861, Sonata-bis 2012/07/E/ST2/01406; the National Priorities Research Program by Qatar National Research Fund; the Programa Estatal de Fomento de la Investigación Científica y Técnica de Excelencia María de Maeztu, grant MDM-2015-0509 and the Programa Severo Ochoa del Principado de Asturias; the Thalis and Aristeia programs cofinanced by EU-ESF and the Greek NSRF; the Rachadapisek Sompot Fund for Postdoctoral Fellowship, Chulalongkorn University and the Chulalongkorn Academic into Its 2nd Century Project Advancement Project (Thailand); the Welch Foundation, contract C-1845; and the Weston Havens Foundation (U.S.A.)