Mapping Terrestrial Impact Craters with the TanDEM-X Digital Elevation Model

The TanDEM-X mission generates a global digital elevation model (DEM) with unprecedented properties. We use it for mapping confirmed terrestrial impact craters as listed in the Earth Impact Database. Both for simple and complex craters detailed investigations of the morphology of the particular structure and of the surrounding terrain can be performed

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells (PECs) to promote invasiveness and cancer progression. To demonstrate this, we developed a 3D model of PEC acini in which thickening and stiffening of basal lamina matrix was induced by advanced glycation end-product (AGE)-dependent non-enzymatic crosslinking of its major components, collagen IV and laminin. We used this model to demonstrate that antibody targeted blockade of CTLD2, the second of eight C-type lectin-like domains in Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) that can recognize glycosylated collagens, reversed actinomyosin-based contractility [myosin-light chain-2 (MLC2) phosphorylation], loss of cell polarity, loss of cell–cell junctions, luminal infiltration and basal invasion induced by AGE-modified basal lamina matrix in PEC acini. Our in vitro results were concordant with luminal occlusion of acini in the prostate glands of adult Endo180ΔEx2–6/ΔEx2–6 mice, with constitutively exposed CTLD2 and decreased survival of men with early (non-invasive) prostate cancer with high epithelial Endo180 expression and levels of AGE. These findings indicate that AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed PECs via a molecular mechanism linked to cancer progression. This study provides a rationale for targeting CTLD2 in Endo180 in prostate cancer and other pathologies in which increased basal lamina thickness and tissue stiffness are driving factors

Serotonin receptor HTR4 as a counter actor of lipid-induced increases of serum glucagon-like peptide-1 levels

Energy demand of neurons in brain that is covered by glucose supply from the blood is ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative diffusion glucose transporters GLUT1-6 and GLUT8, and the N

Continuum Coupling and Single-Nucleon Overlap Integrals

The presence of a particle continuum, both of a resonant and non-resonant character, can significantly impact spectroscopic properties of weakly bound nuclei and excited nuclear states close to, and above, the particle emission threshold. In the framework of the continuum shell model in the complex momentum-plane, the so-called Gamow Shell Model, we discuss salient effects of the continuum coupling on the one-neutron overlap integrals and the associated spectroscopic factors in neutron-rich helium and oxygen nuclei. In particular, we demonstrate a characteristic near-threshold energy dependence of the spectroscopic factors for different l-waves. We show also that the realistic radial overlap functions, which are needed for the description of transfer reactions, can be generated by single-particle wave functions of the appropriately chosen complex potential.Comment: 9 figures; 23 pages; corrected version; accepted in Nuclear Physics

On the evaluation of some three-body variational integrals

Stable recursive relations are presented for the numerical computation of the integrals $$\int d{\bf r}_1 d{\bf r}_2 r_1^{l-1} r_2^{m-1} r_{12}^{n-1} \exp{\{-\alpha r_1 -\beta r_2 -\gamma r_{12}\}}$$ ($l$, $m$ and $n$ integer, $\alpha$, $\beta$ and $\gamma$ real) when the indices $l$, $m$ or $n$ are negative. Useful formulas are given for particular values of the parameters $\alpha$, $\beta$ and $\gamma$.Comment: 12 pages, 1 figure (PS) and 3 tables. Old figures 2 and 3 replaced by Tables I and III. A further table added. Paper enlarged giving some tips on the convergence of quadrature

Conductance and density of states as the Kramers-Kronig dispersion relation

By applying the Kramers-Kronig dispersion relation to the transmission amplitude a direct connection of the conductance with the density of states is given in quantum scattering systems connected to two one-channel leads. Using this method we show that in the Fano resonance the peak position of the density of states is generally different from the position of the corresponding conductance peak, whereas in the Breit-Wigner resonance those peak positions coincide. The lineshapes of the density of states are well described by a Lorentz type in the both resonances. These results are verified by another approach using a specific form of the scattering matrix to describe scattering resonances.Comment: 9 pages, 4 figure

Human Mas-related G protein-coupled receptors-X1 induce chemokine receptor 2 expression in rat dorsal root ganglia neurons and release of chemokine ligand 2 from the human LAD-2 mast cell line

Primate-specific Mas-related G protein-coupled receptors-X1 (MRGPR-X1) are highly enriched in dorsal root ganglia (DRG) neurons and induce acute pain. Herein, we analyzed effects of MRGPR-X1 on serum response factors (SRF) or nuclear factors of activated T cells (NFAT), which control expression of various markers of chronic pain. Using HEK293, DRG neuron-derived F11 cells and cultured rat DRG neurons recombinantly expressing human MRGPR-X1, we found activation of a SRF reporter gene construct and induction of the early growth response protein-1 via extracellular signal-regulated kinases-1/2 known to play a significant role in the development of inflammatory pain. Furthermore, we observed MRGPR-X1-induced up-regulation of the chemokine receptor 2 (CCR2) via NFAT, which is considered as a key event in the onset of neuropathic pain and, so far, has not yet been described for any endogenous neuropeptide. Up-regulation of CCR2 is often associated with increased release of its endogenous agonist chemokine ligand 2 (CCL2). We also found MRGPR-X1-promoted release of CCL2 in a human connective tissue mast cell line endogenously expressing MRGPR-X1. Thus, we provide first evidence to suggest that MRGPR-X1 induce expression of chronic pain markers in DRG neurons and propose a so far unidentified signaling circuit that enhances chemokine signaling by acting on two distinct yet functionally co-operating cell types. Given the important role of chemokine signaling in pain chronification, we propose that interruption of this signaling circuit might be a promising new strategy to alleviate chemokine-promoted pain

The Economic Impact of FHSU on the Local Economy: FY 2022

We evaluate the economic impact Fort Hays State University has on the local economy during fiscal year 2022 by utilizing two estimation methods. These methods focus on the total spending from the institution, the faculty and staff, the students, and the visitors. The results of the analysis estimate the economic impact of the university ranges between $167,862,253 and$239,200,242

Reaction rates for Neutron Capture Reactions to C-, N- and O-isotopes to the neutron rich side of stability

The reaction rates of neutron capture reactions on light nuclei are important for reliably simulating nucleosynthesis in a variety of stellar scenarios. Neutron capture reaction rates on neutron-rich C-, N-, and O-isotopes are calculated in the framework of a hybrid compound and direct capture model. The results are tabulated and compared with the results of previous calculations as well as with experimental results.Comment: 33 pages (uses revtex) and 9 postscript figures, accepted for publication in Phys. Rev.

Systematics of proton emission

A very simple formula is presented that relates the logarithm of the half-life, corrected by the centrifugal barrier, with the Coulomb parameter in proton decay processes. The corresponding experimental data lie on two straight lines which appear as a result of a sudden change in the nuclear shape marking two regions of deformation independently of the angular momentum of the outgoing proton. This feature provides a powerful tool to assign experimentally quantum numbers in proton emitters.Comment: 4 pages, 3 figure