ICTD for Healthcare in Ghana: Two Parallel Case Studies

This paper examines two parallel case studies to promote remote medical consultation in Ghana. These projects, initiated independently by different researchers in different organizations, both deployed ICT solutions in the same medical community in the same year. The Ghana Consultation Network currently has over 125 users running a Web-based application over a delay-tolerant network of servers. OneTouch MedicareLine is currently providing 1700 doctors in Ghana with free mobile phone calls and text messages to other members of the medical community. We present the consequences of (1) the institutional context and identity of the investigators, as well as specific decisions made with respect to (2) partnerships formed, (3) perceptions of technological infrastructure, and (4) high-level design decisions. In concluding, we discuss lessons learned and high-level implications for future ICTD research agendas.Comment: 11 page

A savings subsidization system in a model of endogenous fertility and endogenous growth: an extension of Wigger (1999)

Population ageing is now an established demographic characteristic of many economies. Economists working in the endogenous growth theory tradition have sought to model the relationship between public pensions, financed on a 'Pay-As-You-Go' basis, and the growth in per capita incomes. The resultant intergenerational wealth redistribution from young to older people seems to decrease private savings, diminish capital accumulation, and lower the growth of per capita incomes. The underlying transmission mechanism appears to be a crowding out effect in private capital markets contingent upon the introduction of public pension systems. A growing literature exists on the interrelationships between public pension schemes, fertility rates and endogenous growth. Following Wigger's (1999) pioneering overlapping generations endogenous growth model, we extend this model to examine the effects of a savings subsidisation system on the rate of per capita income growth, fertility and voluntary intrafamily wealth transfers, where parents view children both as an insurance good and a consumption good. Moreover, children care about the consumption levels of their parents. An increase in contributions to a savings subsidised public pension scheme will crowd out private intergenerational transfers from the young to the old and thereby negate the usefulness of children as an insurance good

Development of bite guard for wireless monitoring of bruxism using pressure-sensitive polymer

A wireless pressure sensing bite guard has been developed for monitoring the progress of bruxism (teeth grinding during sleep); as well as for protecting the teeth from damages. For sensing the grinding event effectively in restricted space and hostile environment, a pressure sensitive polymer composite which is safe for intra oral applications has been fabricated and encapsulated into a conventional bite guard. Also encapsulated was a microcontroller-based electronic circuit which was built in-house for data collection and transmission. A low power approach was configured to maximize the working life-time of the device to several months. The device can provide real-time tooth grinding profile through wireless communication. This device is anticipated to be a useful tool for understanding and treating bruxism

Characterization of designed, synthetically accessible bryostatin analog HIV latency reversing agents.

HIV latency in resting CD4+ T cell represents a key barrier preventing cure of the infection with antiretroviral drugs alone. Latency reversing agents (LRAs) can activate HIV expression in latently infected cells, potentially leading to their elimination through virus-mediated cytopathic effects, host immune responses, and/or therapeutic strategies targeting cells actively expressing virus. We have recently described several structurally simplified analogs of the PKC modulator LRA bryostatin (termed bryologs) designed to improve synthetic accessibility, tolerability in vivo, and efficacy in inducing HIV latency reversal. Here we report the comparative performance of lead bryologs, including their effects in reducing cell surface expression of HIV entry receptors, inducing proinflammatory cytokines, inhibiting short-term HIV replication, and synergizing with histone deacetylase inhibitors to reverse HIV latency. These data provide unique insights into structure-function relationships between A- and B-ring bryolog modifications and activities in primary cells, and suggest that bryologs represent promising leads for preclinical advancement

Development of a wireless autonomous bruxism monitoring device

A wireless pressure sensing bite guard has been developed for monitoring the progress of bruxism (teeth grinding during sleep. The pressure sensor was fabricated from carbon-polymer composite which was encapsulated into a conventional prescription biteguard; together with a built in-house microcontroller-based electronics circuit for data collection and data transmission. A low power approach was configured to maximize the working life-time of the device to several months. The device can provide real-time tooth grinding profile through wireless communication. This device is anticipated to be a useful tool for understanding the progress of bruxism treatment

Cohomology of quantum groups: An analog of Kostant's Theorem

We prove the analog of Kostant's Theorem on Lie algebra cohomology in the context of quantum groups. We prove that Kostant's cohomology formula holds for quantum groups at a generic parameter $q$, recovering an earlier result of Malikov in the case where the underlying semisimple Lie algebra $\mathfrak{g} = \mathfrak{sl}(n)$. We also show that Kostant's formula holds when $q$ is specialized to an $\ell$-th root of unity for odd $\ell \ge h-1$ (where $h$ is the Coxeter number of $\mathfrak{g}$) when the highest weight of the coefficient module lies in the lowest alcove. This can be regarded as an extension of results of Friedlander-Parshall and Polo-Tilouine on the cohomology of Lie algebras of reductive algebraic groups in prime characteristic.Comment: 12 page

Crystalline Electric Field and Kondo Effect in SmOs4Sb12

Our ultrasound results obtained in pulsed magnetic fields show that the filled-skutterudite compound SmOs$_4$Sb$_{12}$ has the $\Gamma_{67}$ quartet crystalline-electric-field ground state. This fact suggests that the multipolar degrees of freedom of the $\Gamma_{67}$ quartet play an important role in the unusual physical properties of this material. On the other hand, the elastic response below $\approx$ 20 T cannot be explained using the localized 4$f$-electron model, which does not take into account the Kondo effect or ferromagnetic ordering. The analysis result suggests the presence of a Kondo-like screened state at low magnetic fields and its suppression at high magnetic fields above 20 T even at low temperatures.Comment: 4 pages, 4 figure

Study of heterogeneous nucleation of eutectic Si in high-purity Al-Si alloys with Sr addition

The official published version can be accessed from the link below - Copyright @ 2010 The Minerals, Metals & Materials Society and ASM InternationalAl-5 wt pct Si master-alloys with controlled Sr and/or P addition/s were produced using super purity Al 99.99 wt pct and Si 99.999 wt pct materials in an arc melter. The master-alloy was melt-spun resulting in the production of thin ribbons. The Al matrix of the ribbons contained entrained Al-Si eutectic droplets that were subsequently investigated. Differential scanning calorimetry, thermodynamic calculations, and transmission electron microscopy techniques were employed to examine the effect of the Sr and P additions on eutectic undercoolings and nucleation phenomenon. Results indicate that, unlike P, Sr does not promote nucleation. Increasing Sr additions depressed the eutectic nucleation temperature. This may be a result of the formation of a Sr phase that could consume or detrimentally affect potent AlP nucleation sites.This work is financially supported by the Higher Education Commission of Pakistan and managerially supported from the OAD

A sleep bruxism detection system based on sensors in a splint – pilot clinical data

It is difficult in a dental setting to accurately diagnose sleep bruxism and to objectively assess the severity, frequency or natural history of the condition in an individual patient. Yet this information is essential for the management of sleep bruxism and to plan appropriate dental treatment. The objective of this study was to clinically test a device that could be used to record bruxism events in a home environment. Pressure sensors were developed for use under the surface of an occlusal splint, and circuitry was designed to facilitate the recording and wireless transmission of the pressure sensor signal to a computer. Controlled mandibular movements were carried out in vivo to simulate bruxism and non-bruxism patterns. These patterns of force application were graphically presented to two examiners who were asked to identify the type of activity represented by the force curves. Examiners were largely able to distinguish bruxism from non-bruxism activity; the sensitivity ranged from 80% to 100% and the specificity from 75% to 100%. Using sensors in an occlusal splint, it is possible to recognise the typical tooth contact patterns seen in sleep bruxism. Such a device may be useful for monitoring sleep bruxism over an extended period at home