The Angular Distribution of Photoneutrons From O16

The relative importance of competing reaction channels in the photo-excitation of the giant resonance in O16 has been studied by measurement of the angular distribution of the emitted photo-neutrons through the corresponding energy range using a multi-angle neutron time of flight spectrometer installed at the Kelvin Laboratory of the University of Glasgow. Design factors for the spectrometer are discussed with regard to optimisation of energy resolution and counting rates under the constraints of the source, and the obtainable accuracy of normalisation between neutron detectors at different angles has been measured, A reliable method of calibration of the neutron energy scale at each angle is described and corrections to the neutron spectra for absorption by materials in the flight path have been made. The energy dependent efficiency of the neutron detectors is calculated in an appendix by a Monte Carlo technique using a new measurement of the scintillation response curve for recoil protons. Angular distributions of photoneutrons from the D2 (gamma,n)p reaction with 26.9 MeV bremsstrahlung have been measured and are found to agree with previously published results and theoretical predictions to within the expected accuracy. This is taken as confirmation of good angular normalisation in the system. Measurements by the author of the angular distributions of photo-neutrons from 26.9 MeV bremsstrahlung on O16 are presented and absolute cross sections have been obtained with respect to that known for deuterium. Photoproton data from other authors is analysed in a similar way for comparison with the photoneutron results. In the E1 approximation, the relative intensity of s/d wave admixture is found to follow the resonance structure for both protons and neutrons and the corresponding phase difference is found to vary about the value expected from optical model predictions. The E2 cross section has been extracted from the data and is found to rest mainly in two broad states centred at about 23 MeV and 24.7 MeV, while a Barker-Mann analysis shows the isospin impurity in the O16 giant resonance to be small and to be mainly associated with the regions of E2 strength. The pure 1p1h dipole approximation fails to describe these features and the observed splitting of the giant resonance in O16 but the presence of more complicated excitations is shown to be more consistent with experiment

Polymorphisms in the CTLA4 promoter sequence are associated with canine hypoadrenocorticism

Canine hypoadrenocorticism is an immune-mediated endocrinopathy that shares both clinical and pathophysiological similarities with Addison’s disease in humans. Several dog breeds are overrepresented in the disease population, suggesting that a genetic component is involved, although this is likely to be polygenic. Previous research has implicated CTLA4 as a potential susceptibility gene. CTLA4 is an important regulator of T cell function and polymorphisms/mutations in CTLA4 have been associated with a number of autoimmune phenotypes in both humans and rodent models of autoimmunity. The aim of the current study was to undertake a case:control association study of CTLA4 promotor polymorphisms in three dog breeds, cocker spaniels, springer spaniels and West Highland white terriers (WHWT)

A longitudinal study of autoantibodies against cytochrome P450 side-chain cleavage enzyme in dogs (Canis lupus familiaris) affected with hypoadrenocorticism (Addison’s disease)

Autoantibodies directed against the P450 side chain cleavage enzyme (P450scc) have been recently described in dogs affected with hypoadrenocorticism, consistent with an immune-mediated pathogenesis of this endocrinopathy. In human autoimmune Addison’s disease, autoantibodies may have a predictive value, being detectable before clinical signs developing, and have been shown to persist for a period of time after diagnosis. Furthermore, an autoantibody positive status post-diagnosis has been associated with successful remission of Addison’s disease following B-cell depletion, suggesting active immunopathology in these cases. The current study was designed to investigate changes in serum P450scc autoantibody status over time in dogs diagnosed with spontaneous hypoadrenocorticism. P450scc autoantibodies were measured using a species-specific radioimmunoprecipitation assay in an initial cohort of 213 dogs, indicating a prevalence of 24%. Thirty two of these dogs had repeat samples (n = 80 in total) available for analysis. Five dogs were consistently P450scc autoantibody positive in all samples, for up to 425 days following first sampling. Three dogs were initially autoantibody positive, then became seronegative at later time points. One dog, a 1 year old female entire standard poodle, was initially negative for P450scc autoantibodies, but seroconverted 18 months after diagnosis. The remaining 23 dogs with multiple samples available were consistently P450scc autoantibody negative. Persistence was not associated with sex (p = 0.673). This study demonstrates persistence of P450scc autoantibodies in a subset of dogs affected with hypoadrenocorticism and seroconversion over one year post-diagnosis. P450scc autoantibody reactivity in human autoimmune Addison’s disease has been associated with sex, with females having a higher prevalence, possibly due to P450scc expression in the ovary acting as an additional source of antigenic stimulation. However, there was no sex difference in autoantibody persistence in the dogs affected with hypoadrenocorticism. Autontibody persistence in dogs with hypoadrenocorticism might represent persistent pathology, due to residual antigenic stimulation and autoimmune inflammation in the adrenal gland.<br/

Thermoluminescence measurements of neutron streaming through JET Torus Hall ducts

Thermoluminescence detectors (TLD) were used for dose measurements at JET. Several hundreds of LiF detectors of various types, standard LiF:Mg,Ti and highly sensitive LiF:Mg,Cu,P were produced. LiF detectors consisting of natural lithium are sensitive to slow neutrons, their response to neutrons being enhanced by 6Li-enriched lithium or suppressed by using lithium consisting entirely of 7Li. Pairs of 6LiF/7LiF detectors allow distinguishing between neutron/non-neutron components of a radiation field. For detection of neutrons of higher energy, polyethylene (PE-300) moderators were used. TLDs, located in the centre of cylindrical moderators, were installed at eleven positions in the JET hall and the hall labyrinth in July 2012, and exposure took place during the last two weeks of the experimental campaign. Measurements of the gamma dose were obtained for all positions over a range of about five orders of magnitude variation. As the TLDs were also calibrated in a thermal neutron field, the neutron fluence at the experimental position could be derived. The experimental results are compared with calculations using the MCNP code. The results confirm that the TLD technology can be usefully applied to measurements of neutron streaming through JET Torus Hall ducts.Comment: Presented at the 11th International Symposium on Fusion Nuclear Technology (ISFNT), held in Barcelona, Spain, from 16-20 September 201

Porous Silica Nanotube Thin Films as Thermally Insulating Barrier Coatings

The fabrication and examination of a porous silica thin film, potentially for use as an insulating thin film, were investigated. A vertically aligned carbon nanotube (CNT) forest, created by chemical vapor deposition (CVD), was used as scaffolding to construct the porous film. Silicon was deposited on the CNT forest using low-pressure CVD (LPCVD) and then oxidized to remove the CNTs and convert the silicon to silica for electrical or thermal passivation (e.g., thermal barrier). Thermal conductivity was determined using a 1D heat-transfer analysis that equated radiative heat loss in a vacuum with conduction through the substrate and thin film stack. A comparison of the surface temperature differences between a sample film and a reference of comparable thermal resistance enabled determination of the increase in the thermal resistance and of the thermal conductivity of the films. For film thicknesses of approximately 55 μm, the cross-plane thermal conductivity was found to be 0.054−0.071 W m−1 K−1 over 378−422 K. This thermal conductivity value is in the range of other silica aerogels and consistent with the low gravimetric density of 0.15 g cm−3 for the samples. The film is also relatively smooth and flat, with an average arithmetic mean roughness of 1.04 μm

Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical research.Peer reviewe

Social cultural influences on current and future coastal governance

Australians have strong attachments to the coast. The impact of climate change brings to the fore deep-seated socio-cultural values, which add to the already complex and uncertain biophysical changes that challenge our preparations for future climate change. Our research aims to examine the role of worldviews and deep seated values in decision-making in response to climate change. The objective is to show how a multi-layered discourse analysis using causal layered analysis (CLA) can provide a powerful means of revealing the underlying social and cultural influences on decision-making and provide more insight into potential pathways for more effective responses to complex phenomena such as climate change. A case study of coastal governance in the south west of Western Australia, which is highly vulnerable to sea-level rise, provides the context of the research.We have found that CLA as a critical research tool has proven to be a useful method in uncovering the dominance of the administrative rationalist worldview on coastal governance. In our view, future coastal governance would benefit from a shift towards greater participatory governance and the incorporation of more reflexive practice so that the deeper emotional and relational aspects of decision-making balance out the dominant problem-solving discourse