The Importance of Strategic Fit in Knowledge Management

Whilst a great deal of academic research and many methods used by consultants and practitioners in knowledge management have focused on developing successful strategies, few have reviewed strategic-fit. This project aims to fill this gap. A survey of over 150 organisations discovers distinct variations in the knowledge orientation of organisations with different strategic approaches. These findings support the notion that in order to achieve a more effective KM strategy it is important to match this closely to the strategic needs of the organisation. One size does not fit all. The study identifies a number of success factors for each of four strategic types of organisation and describes how these are correlated with overall performance. The focus is on adaptability to changes in the external environment and more generally on business agilit

Lysosome-mediated processing of chromatin in senescence

Cellular senescence is a stable proliferation arrest, a potent tumor suppressor mechanism, and a likely contributor to tissue aging. Cellular senescence involves extensive cellular remodeling, including of chromatin structure. Autophagy and lysosomes are important for recycling of cellular constituents and cell remodeling. Here we show that an autophagy/lysosomal pathway processes chromatin in senescent cells. In senescent cells, lamin A/C–negative, but strongly γ-H2AX–positive and H3K27me3-positive, cytoplasmic chromatin fragments (CCFs) budded off nuclei, and this was associated with lamin B1 down-regulation and the loss of nuclear envelope integrity. In the cytoplasm, CCFs were targeted by the autophagy machinery. Senescent cells exhibited markers of lysosomal-mediated proteolytic processing of histones and were progressively depleted of total histone content in a lysosome-dependent manner. In vivo, depletion of histones correlated with nevus maturation, an established histopathologic parameter associated with proliferation arrest and clinical benignancy. We conclude that senescent cells process their chromatin via an autophagy/lysosomal pathway and that this might contribute to stability of senescence and tumor suppression

Workforce Agility: The New Employee Strategy for the Knowledge Economy

The notion of the agile workforce has been discussed as central to creating the agile organization, which achieves superior environmental responsiveness in contexts of turbulence and change. Previous agility research has focused overly on the organization, paying scant attention to the workforce. This paper addresses a significant gap in agility research by reporting on the first empirical study to examine how the pressures of organizational agility impact upon the workforce. Survey evidence from 515 UK organizations is used for eliciting an initial indicator of workforce agility. The data suggest that agile workforces acquire the five capabilities of intelligence, competencies, collaboration, culture and information systems (IS). From an information technology (IT) perspective the determinants of workforce agility are flexible infrastructure platforms that support the rapid introduction of new IS and the enhancement of IT competencies across the entire workforce. The survey also revealed that information and communications technology applications increase workforce agility most when used for collaborative working

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

Age of First Overweight and Obesity, COVID-19 and Long COVID in Two British Birth Cohorts

Longer exposure to obesity, and thus a longer period in an inflamed state, may increase susceptibility to infectious diseases and worsen severity. Previous cross-sectional work finds higher BMI is related to worse COVID-19 outcomes, but less is known about associations with BMI across adulthood. To examine this, we used body mass index (BMI) collected through adulthood in the 1958 National Child Development Study (NCDS) and the 1970 British Cohort Study (BCS70). Participants were grouped by the age they were first overweight (> 25 kg/m2) and obese (> 30 kg/m2). Logistic regression was used to assess associations with COVID-19 (self-reported and serology-confirmed), severity (hospital admission and contact with health services) and long-COVID reported at ages 62 (NCDS) and 50 (BCS70). An earlier age of obesity and overweight, compared to those who never became obese or overweight, was associated with increased odds of adverse COVID-19 outcomes, but results were mixed and often underpowered. Those with early exposure to obesity were over twice as likely in NCDS (odds ratio (OR) 2.15, 95% confidence interval (CI) 1.17-4.00) and three times as likely in BCS70 (OR 3.01, 95% CI 1.74-5.22) to have long COVID. In NCDS they were also over four times as likely to be admitted to hospital (OR 4.69, 95% CI 1.64-13.39). Most associations were somewhat explained by contemporaneous BMI or reported health, diabetes or hypertension; however, the association with hospital admission in NCDS remained. An earlier age of obesity onset is related to COVID-19 outcomes in later life, providing evidence of the long-term impact of raised BMI on infectious disease outcomes in midlife

Conceptualizing Narrative Structures and Institutions: A Case Study of Institutional Closings in Detroit

We address the pervasive problem in narrative inquiry of linking personal to collective stories. Our approach is to distinguish stories as personal accounts from narrative structures that are cultural frames. We examined the relations between the two, and argue that narrative structures in many ways prefigure personal stories. We then present data pertaining to the closings of three Detroit institutions: Hudson\u27s Department Store, the Fleetwood Cadillac Plant, and local parishes of the Detroit Archdiocese. With these data, we suggest that narrative structures also may well be linked to social institutions

Selective Quantification of Charged and Neutral Polyfluoroalkyl Substances Using the Total Oxidizable Precursor (TOP) Assay.

Perfluoroalkyl acid (PFAA) precursors are a diverse subclass of per- and polyfluoroalkyl substances (PFASs) that can be transformed into PFAAs of public health concern. Unlike strongly acidic PFAAs, precursors can be anionic, cationic, neutral, or zwitterionic. Precursor charge affects the environmental fate, but existing quantification techniques struggle to ascertain the abundance of compounds within each charge group. To fill this gap, we developed and validated a solid-phase extraction procedure that separates precursors by charge and quantifies the sum of the precursors in each fraction with the total oxidizable precursor (TOP) assay. Method performance was demonstrated by spiking known concentrations of ten precursors into aqueous film-forming foam (AFFF)-impacted groundwater, municipal wastewater, and soil samples. Precursor fractionation and recovery were greater in groundwater and soil samples than in wastewater. Use of the method provided results that were consistent with expectations based on precursor transport properties. In surficial soils near an AFFF source zone, anionic precursors with five or fewer perfluorinated carbons accounted for about 95% of PFASs, but less than half of PFASs in the underlying groundwater. In municipal wastewater influent, the sum of precursors exceeded the sum of PFAAs and was approximately equally distributed among all charge fractions