In Vitro and in Vivo Anti-Diabetic Activity of Rhododendron Griffithianum for Insulin Dependent (Type I) Diabetes Mellitus

Diabetes mellitus, a chronic metabolic disorder, poses a significant global health challenge, with the insulin-dependent (Type I) form requiring continuous therapeutic interventions. In this study, we investigate the potential anti-diabetic properties of Rhododendron griffithianum through both in vitro and in vivo assessments, targeting the specific needs of individuals with Type I diabetes. The in vitro phase involves the exploration of the inhibitory effects of Rhododendron griffithianum extracts on key enzymes involved in glucose metabolism, such as α-amylase and α-glucosidase. Additionally, the impact on glucose uptake in insulin-sensitive cells will be assessed to elucidate potential mechanisms of action at the cellular level. The in vivo component of the study employs an animal model of Type I diabetes to evaluate the efficacy of Rhododendron griffithianum in ameliorating hyperglycemia and associated complications. Diabetic animals will be treated with different doses of Rhododendron griffithianum extracts, and parameters including blood glucose levels, insulin sensitivity, lipid profile, and histopathological changes in pancreatic tissue will be examined. The findings from this research may provide valuable insights into the development of novel therapeutic agents for managing Type I diabetes. Moreover, the dual in vitro and in vivo approach enhances the translational relevance of the study, bridging the gap between laboratory discoveries and clinical applications. The results could potentially pave the way for the development of Rhododendron griffithianum-derived pharmaceuticals or nutraceuticals as adjunctive therapies for individuals with insulin-dependent diabetes

Experimental Shear Study on Reinforced High Strength Concrete Beams Made Using Blended Cement

With the increased application of High Strength Concrete (HSC) inconstruction and lack of proper guidelines for structural design in India,behavioral study of high strength concrete is an important aspect ofresearch. Research on the behavior of HSC reinforced beams with concretestrength more than 60 MPa has been carried out in the past and is stillcontinuing to understand the structural behavior of HSC beams. Along withthe many benefits of the high strength concrete, the more brittle behavior isof concern which leads to sudden failure. This paper presents the behaviorof reinforced HSC beams in shear with considering the effects of variousfactors like shear reinforcement ratio, longitudinal reinforcement ratio, l/dratio (length to depth ratio), etc. Ten numbers Reinforced Concrete Beamsof various sizes using concrete mix with three different w/c ratios (0.46, 0.26and 0.21) were cast for shear strength assessment. The beams were tested insimply supported condition over two fixed steel pedestals with load rate of0.2 mm/minute in displacement control. Mid-point deflection was measuredusing LVDT. A comparative analysis of theoretical approaches of Eurocode, extension of current IS code up to M90 and the experimental datawas done to understand the behavior of beams. Shear capacities of beamswithout any factors of safety were used to assess the actual capacities andthen was compared with the experimental capacity obtained. Results ofthis study can be used in the design of high strength concrete and will bemore reliable in Indian continent as the regional materials and exposureconditions were considered

Evaluation of simple International ovarian tumor analysis ultra sound rules in differentiating between benign and malignant ovarian tumors and their histopathological correlation

Background: IOTA (International ovarian tumor analysis) study is considered one of the largest studies on ultrasound diagnosis of ovarian pathology conducted in literature till date. It was started in 1999 and included nine European countries. It is a standardized technique for preoperative classification of ovarian pathology defined by IOTA group.Methods: A retrospective study was analyzed from a period of January 2016 to December 2017 (2-year period). The records of all the patients operated for benign and malignant ovarian pathology in the gynae department of hospital were retrieved from medical record sections. USG findings were redefined as per IOTA simple rules by sonologist and its histopathological correlation was done using kappa statistical method.Results: In the present study, out of 61 patients IOTA was applicable to 57 patients. The sensitivity where IOTA simple rules were applicable was 92.8% and the specificity was 93%. The accuracy turned out to be 92.9%. If inconclusive results were taken as malignant then sensitivity increased to 94% and specificity decreased to 87%. Good level of agreement was found between sonological and histopathological findings with Kappa statistics application (K = 0.59).Conclusions: The IOTA simple rules can be considered as an important diagnostic modality in differentiation of benign and malignant ovarian tumors, it has an added advantage of abolishing the subjectivity of routine ultrasound. However inconclusive results demand further expertise in the field and need to be taken care of before interpretation of ovarian pathologies

Use of bottom ash as part replacement of sand for making concrete blocks

Coal-based thermal power plants all over the world facing serious problems of handling and disposal of the ash produced. The productive use of coal Bottom Ash (BA) is the best way to alleviate the problems associated with its disposal. This paper covers the studies on laboratory scale evaluation of vibro compaction concrete blocks using BA I, BA II & BA III collected from three different location of Coal Fed Thermal Power Station. In the present investigation laboratory investigation have been carried to utilize BA as part replacement of sand in concrete. This study cover manufacture of concrete blocks without flyash & with BA using for making solid block as per specification laid down in IS:2185 using vibro compaction machine. Three different sources of BA were used in concrete mix each @ 30%, 40% & 50% replacement by weight of sand were adopted in making concrete blocks. Comparative study of compressive strength of concrete at different age of curing, wet density, drying shrinkage is reported in this study. Wet density is found to be lower in blocks containing BA & dry shrinkage values are found well within the limits of specifications. Concrete Blocks having BA @ 30% by weight of sand are found suitable for use in the manufacture of concrete blocks

Spinal tuberculoma in a patient with spinal myxopapillary ependymoma

Intramedullary spinal tuberculosis is a clinical curiosity. A 19-year-old female was diagnosed and treated for lumbosacral myxopapllary ependy moma (MPE). Three years later, she presented with back pain and hypoesthesia of the left upper limb. Besides revealing local recurrence, the MRI demonstrated a fresh lesion in the cervicomedullary area. The latter was operated and the histopathology revealed a tuberculoma

Acute kidney injury requiring dialysis and in‐hospital mortality in patients with chronic kidney disease and non–ST‐segment elevation acute coronary syndrome undergoing early vs delayed percutaneous coronary intervention: A nationwide analysis

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141458/1/clc22828.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/141458/2/clc22828_am.pd

Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations

Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017 : a systematic analysis for the Global Burden of Disease Study 2017

Background: The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk outcome pairs, and new data on risk exposure levels and risk outcome associations. Methods: We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings: In 2017,34.1 million (95% uncertainty interval [UI] 33.3-35.0) deaths and 121 billion (144-1.28) DALYs were attributable to GBD risk factors. Globally, 61.0% (59.6-62.4) of deaths and 48.3% (46.3-50.2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10.4 million (9.39-11.5) deaths and 218 million (198-237) DALYs, followed by smoking (7.10 million [6.83-7.37] deaths and 182 million [173-193] DALYs), high fasting plasma glucose (6.53 million [5.23-8.23] deaths and 171 million [144-201] DALYs), high body-mass index (BMI; 4.72 million [2.99-6.70] deaths and 148 million [98.6-202] DALYs), and short gestation for birthweight (1.43 million [1.36-1.51] deaths and 139 million [131-147] DALYs). In total, risk-attributable DALYs declined by 4.9% (3.3-6.5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23.5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18.6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation: By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning