The effect of partial portacaval transposition on the canine liver

The influence of nonhepatic splanchnic venous blood on dog liver morphology and biochemical content was investigated by performing partial portacaval transposition, anastomosing the supra-adrenal inferior vena cava to either the right or left branch of the main portal vein. In the resulting preparation, nonhepatic splanchnic venous blood supplies one portion of the liver and systemic venous blood perfuses the remaining fraction,. Seven dogs were studied for 70 to 94 days, 3 with right and 4 with left transposition. No clinical abnormalities were noted. Transient enzyme elevations were seen early after operation but reverted to normal. The most striking feature was the gross and microscopic atrophy and deglycogenation which occurred in the part of the liver receiving systemic venous blood. Blood flow studies were performed in 8 additional dogs with an electromagnetic square wave flowmeter. Flow was measured in both right and left portal vein branches before and 1 to 4 hours after partial transposition to either the right (4 dogs) or left (4 dogs) main branch. Flow rates were increased in 11 instances and remained essentially the same in 5. In 2 more dogs, a jugular venous autograft was placed between the abdominal aorta and the right or left main portal vein branch. Atrophy and deglycogenation in the portion receiving arterial blood was comparable to that described above in liver fractions perfused with systemic venous blood. The evidence from these and earlier experiments that splanchnic venous blood contains a hepatotrophic substance is discussed. © 1967

Early Idamean (Late Cambrian) agnostoid trilobites from the Huskisson River, Tasmania

Two trilobite taxa, Agnostus (Homagnostus) sp. and Pseudagnostus (Pseudagnostus) idalis huskissonensissubsp. nov. are described from the upper part of the Huskisson Group, western Tasmania. The only trilobite previously described from this level is the early Idamean (early Late Cambrian) zone fossil Glyptagnostus reticulatus. Palaeontological and stratigraphic evidence suggests that there may be a disconformity of very late Middle Cambrian age (about Lejopyge laevigata III Zone) within the Huskisson Group, which would correspond to a postulated disconformity of similar age from the Dundas Group at Dundas

Late Middle Cambrian trilobites from Trial Ridge, southwestern Tasmania

The first Middle Cambrian trilobites to be described from southwestern Tasmania come from two localities within siltstone in the Trial Ridge area on the HUNTLEY 1:50 000 sheet. Sixteen trilobite taxa are described. The 11 agnostoid species include one new species, Hypagnostus trali. Lisogoragnostus is recorded for the first time in Tasmania. The faunas of both localities are of a very similar late Middle Cambrian age, probably high in the Lejopyge laevigata Zone on the northern Australian biostratigraphic scale. One fauna is dominated by complete specimens of Goniagnostus nathorsti but has very few polymeroids. In the other fauna, there are no complete agnostoids, G. nathorsti is absent, and the most common trilobite is a member of the Proasaphiscidae, thus suggesting that the former fauna is of deeper water origin than the latte

The third moment of quadratic Dirichlet L-functions

We study the third moment of quadratic Dirichlet L-functions, obtaining an error term of size $O(X^{3/4 + \varepsilon})$.Comment: 27 pages. v2: modified a remark on p.

Regeneration characteristics of a swamp forest in northwestern Tasmania

The botanical composition and regeneration characteristics are described for a Melaleuca ricifoliaLeptospermum lanigerum forest from northwestern Tasmania. The size classes of the two dominant species are highly correlated with tree age. Size class analysis shows that the dominants are regenerating continuously. The relationship of this forest type to rainforest and wet sclerophyll forest are discussed

Recent Progress in Neutron Star Theory

This review contains chapters discussing: Energy density fluctionals of nuclear matter, Many-body theory of nucleon matter, Hadronic and quark matter, Mixtures of phases in dense matter, Neutron star observations and predictions.Comment: 33 pages +13 figs., Ann. Rev. Nucl. & Part. Science, 200

Domestic Workload and Multiple Roles. Epidemiological findings on health and sickness absence in women

Aim: The objective of this thesis was to analyse the importance of specific exposures in women’s lives to health and sickness absence; more precisely to study the association between domestic work, multiple roles and the experience of being sick-listed, and self-rated health, psychiatric disorders and sickness absence. Method: The thesis was based on two datasets. ‘Women’s health and living conditions’ (WHL) is a cross-sectional study on 1 417 employed women aged 17 to 64 years old. Data was collected with a questionnaire, and register and employee data on sickness absence. ‘Women and alcohol in Göteborg’ (WAG) is a prospective cohort study on 1 799 women in eight age cohorts born from 1925 to 1980. Data was collected with a screening questionnaire, interviews and register-based sickness absence. Several aspects of domestic work, multiple roles and experience of sickness absence were analysed in relation to self-rated health (SF-36), psychiatric disorders (DSM-III and IV) and sickness absence. The study on multiple roles emanated from the role strain and role enhancement hypotheses and roles were analysed as single roles and as combinations of roles. Changes in self-rated physical health were assessed in relation to experience of sickness absence over five year. Cross-sectional and longitudinal analyses were conducted using multivariate regressions analyses. Results: Domestic job strain and a lack of domestic work equity and marital satisfaction were associated with lower self-rated health particularly vitality and mental health. The former was not associated to sickness absence, but the latter was. Women with domestic workload due to children and adults with special needs had higher odds for medium-long sick-leave spells, while parental responsibility gave lower odds for any sick-leave spell. Occupation was related to lower odds for poor self-rated physical health and sickness absence, while the parental role was associated with higher odds for sickness absence. Compared with women who had all three roles women with occupation and partner role had lower odds for negative health outcomes. Support was found for the role strain hypothesis in the cross-sectional analyses of role combinations while neither of the hypotheses was supported in the five year follow up. A lower proportion of those who had experience of being sick-listed reported good health at both baseline and follow up. Women with psychiatric disorders had higher odds for a change from poor to good self-rated physical health over the five years if they had been sick-listed. Conclusion: Domestic workload was associated to health and sickness absence in women, but there were inconsistencies in the findings on children and being a parent and on multiple roles. From a public health perspective, deeper knowledge on the importance of women’s engagement domestic work and its different dimensions is important for promoting women’s health. A multidimensional assessment of domestic work is important and the content and complexity of domestic work and of different roles needs to be further explored in relation to health and sickness absence in women

Regression of murine lung tumors by the let-7 microRNA.

MicroRNAs (miRNAs) have recently emerged as an important new class of cellular regulators that control various cellular processes and are implicated in human diseases, including cancer. Here, we show that loss of let-7 function enhances lung tumor formation in vivo, strongly supporting the hypothesis that let-7 is a tumor suppressor. Moreover, we report that exogenous delivery of let-7 to established tumors in mouse models of non-small-cell lung cancer (NSCLC) significantly reduces the tumor burden. These results demonstrate the therapeutic potential of let-7 in NSCLC and point to miRNA replacement therapy as a promising approach in cancer treatment

Evidence for the classical integrability of the complete AdS(4) x CP(3) superstring

We construct a zero-curvature Lax connection in a sub-sector of the superstring theory on AdS(4) x CP(3) which is not described by the OSp(6|4)/U(3) x SO(1,3) supercoset sigma-model. In this sub-sector worldsheet fermions associated to eight broken supersymmetries of the type IIA background are physical fields. As such, the prescription for the construction of the Lax connection based on the Z_4-automorphism of the isometry superalgebra OSp(6|4) does not do the job. So, to construct the Lax connection we have used an alternative method which nevertheless relies on the isometry of the target superspace and kappa-symmetry of the Green-Schwarz superstring.Comment: 1+26 pages; v2: minor typos corrected, acknowledgements adde