25,037 research outputs found
Cats, comics and Knausgård : promoting student reading at a UK academic library with a leisure reading collection
This case study describes the creation of a leisure reading collection in the Clifford Whitworth library at the University of Salford. It briefly surveys existing literature on leisure reading collections and looks at the growing interest among UK academic libraries in recreational reading. It considers the reasons for promoting reading as a leisure activity to students and describes the processes of selecting, purchasing and marketing the collection at Salford. It also considers possible future developments for the collection and the evaluation of the library’s attempts to encourage a culture of reading amongst Salford students. The positive response to the collection suggests the development of leisure reading is a worthwhile activity for academic libraries to focus on and the study contains useful information for others who are interested in creating a similar collection
KCNQ/M currents in sensory neurons: Significance for pain therapy
Neuronal hyperexcitability is a feature of epilepsy and both inflammatory and neuropathic pain. M currents [I-K(M)] play a key role in regulating neuronal excitability, and mutations in neuronal KCNQ2/3 subunits, the molecular correlates of I-K(M), have previously been linked to benign familial neonatal epilepsy. Here, we demonstrate that KCNQ/M channels are also present in nociceptive sensory systems. I-K(M) was identified, on the basis of biophysical and pharmacological properties, in cultured neurons isolated from dorsal root ganglia (DRGs) from 17-d-old rats. Currents were inhibited by the M-channel blockers linopirdine (IC50, 2.1 muM) and XE991 (IC50, 0.26 muM) and enhanced by retigabine (10 muM). The expression of neuronal KCNQ subunits in DRG neurons was confirmed using reverse transcription-PCR and single-cell PCR analysis and by immunofluorescence. Retigabine, applied to the dorsal spinal cord, inhibited C and Adelta fiber-mediated responses of dorsal horn neurons evoked by natural or electrical afferent stimulation and the progressive "windup" discharge with repetitive stimulation in normal rats and in rats subjected to spinal nerve ligation. Retigabine also inhibited responses to intrapaw application of carrageenan in a rat model of chronic pain; this was reversed by XE991. It is suggested that I-K(M) plays a key role in controlling the excitability of nociceptors and may represent a novel analgesic target
Stages of development and injury: an epidemiological survey of young children presenting to an emergency department
<p><b>Background:</b> The aim of our study was to use a local (Glasgow, west of Scotland) version of a Canadian injury surveillance programme (CHIRPP) to investigate the relationship between the developmental stage of young (pre-school) children, using age as a proxy, and the occurrence (incidence, nature, mechanism and location) of injuries presenting to a Scottish hospital emergency department, in an attempt to replicate the findings of a recent study in Kingston, Canada.</p>
<p><b>Methods:</b> We used the Glasgow CHIRPP data to perform two types of analyses. First, we calculated injury rates for that part of the hospital catchment area for which reasonably accurate population denominators were available. Second, we examined detailed injury patterns, in terms of the circumstances, mechanisms, location and types of injury. We compared our findings with those of the Kingston researchers.</p>
<p><b>Results:</b> A total of 17,793 injury records for children aged up to 7 years were identified over the period 1997–99. For 1997–2001, 6,188 were used to calculate rates in the west of the city only. Average annual age specific rates per 1000 children were highest in both males and females aged 12–35 months. Apart from the higher rates in Glasgow, the pattern of injuries, in terms of breakdown factors, mechanism, location, context, and nature of injury, were similar in Glasgow and Kingston.</p>
<p><b>Conclusion:</b> We replicated in Glasgow, UK, the findings of a Canadian study demonstrating a correlation between the pattern of childhood injuries and developmental stage. Future research should take account of the need to enhance statistical power and explore the interaction between age and potential confounding variables such as socio-economic deprivation. Our findings highlight the importance of designing injury prevention interventions that are appropriate for specific stages of development in children.</p>
Recent Progress in Neutron Star Theory
This review contains chapters discussing: Energy density fluctionals of
nuclear matter, Many-body theory of nucleon matter, Hadronic and quark matter,
Mixtures of phases in dense matter, Neutron star observations and predictions.Comment: 33 pages +13 figs., Ann. Rev. Nucl. & Part. Science, 200
Fano 3-folds in P2xP2 format, Tom and Jerry
We study Q-factorial terminal Fano 3-folds whose equations are modelled on those of the Segre embedding of P^2xP^2. These lie in codimension 4 in their total anticanonical embedding and have Picard rank 2. They fit into the current state of classification in three different ways. Some families arise as unprojections of degenerations of complete intersections, where the generic unprojection is a known prime Fano 3-fold in codimension 3; these are new, and an analysis of their Gorenstein projections reveals yet other new families. Others represent the "second Tom" unprojection families already known in codimension 4, and we show that every such family contains one of our models. Yet others have no easy Gorenstein projection analysis at all, so prove the existence of Fano components on their Hilbert scheme
The order of the quantum chromodynamics transition predicted by the standard model of particle physics
We determine the nature of the QCD transition using lattice calculations for
physical quark masses. Susceptibilities are extrapolated to vanishing lattice
spacing for three physical volumes, the smallest and largest of which differ by
a factor of five. This ensures that a true transition should result in a
dramatic increase of the susceptibilities.No such behaviour is observed: our
finite-size scaling analysis shows that the finite-temperature QCD transition
in the hot early Universe was not a real phase transition, but an analytic
crossover (involving a rapid change, as opposed to a jump, as the temperature
varied). As such, it will be difficult to find experimental evidence of this
transition from astronomical observations.Comment: 7 pages, 4 figure
Evaluation of turbulence closure models under spilling and plunging breakers in the surf zone
Turbulence closure models are evaluated for application to spilling and plunging breakers in the surf zone using open source computational fluid dynamics software. A new library of turbulence models for application to multiphase flows has been developed and is assessed for numerical efficiency and accuracy by comparing against existing laboratory data for surface elevation, velocity and turbulent kinetic energy profiles. Out of the models considered, it was found that, overall, the best model is the nonlinear k - ϵ model. The model is also shown to exhibit different turbulent characteristics between the different breaker types, consistent with experimental data
The wavelet-NARMAX representation : a hybrid model structure combining polynomial models with multiresolution wavelet decompositions
A new hybrid model structure combing polynomial models with multiresolution wavelet decompositions is introduced for nonlinear system identification. Polynomial models play an important role in approximation theory, and have been extensively used in linear and nonlinear system identification. Wavelet decompositions, in which the basis functions have the property of localization in both time and frequency, outperform many other approximation schemes and offer a flexible solution for approximating arbitrary functions. Although wavelet representations can approximate even severe nonlinearities in a given signal very well, the advantage of these representations can be lost when wavelets are used to capture linear or low-order nonlinear behaviour in a signal. In order to sufficiently utilise the global property of polynomials and the local property of wavelet representations simultaneously, in this study polynomial models and wavelet decompositions are combined together in a parallel structure to represent nonlinear input-output systems. As a special form of the NARMAX model, this hybrid model structure will be referred to as the WAvelet-NARMAX model, or simply WANARMAX. Generally, such a WANARMAX representation for an input-output system might involve a large number of basis functions and therefore a great number of model terms. Experience reveals that only a small number of these model terms are significant to the system output. A new fast orthogonal least squares algorithm, called the matching pursuit orthogonal least squares (MPOLS) algorithm, is also introduced in this study to determine which terms should be included in the final model
Resource use data by patient report or hospital records: Do they agree?
Background: Economic evaluations alongside clinical trials are becoming increasingly common.
Cost data are often collected through the use of postal questionnaires; however, the accuracy of
this method is uncertain. We compared postal questionnaires with hospital records for collecting
data on physiotherapy service use.
Methods: As part of a randomised trial of orthopaedic medicine compared with orthopaedic
surgery we collected physiotherapy use data on a group of patients from retrospective postal
questionnaires and from hospital records.
Results: 315 patients were referred for physiotherapy. Hospital data on attendances was available
for 30% (n = 96), compared with 48% (n = 150) of patients completing questionnaire data (95% Cl
for difference = 10% to 24%); 19% (n = 59) had data available from both sources. The two methods
produced an intraclass correlation coefficient of 0.54 (95% Cl 0.31 to 0.70). However, the two
methods produced significantly different estimates of resource use with patient self report recalling
a mean of 1.3 extra visits (95% Cl 0.4 to 2.2) compared with hospital records.
Conclusions: Using questionnaires in this study produced data on a greater number of patients
compared with examination of hospital records. However, the two data sources did differ in the
quantity of physiotherapy used and this should be taken into account in any analysi
Conditional Sampling for Max-Stable Processes with a Mixed Moving Maxima Representation
This paper deals with the question of conditional sampling and prediction for
the class of stationary max-stable processes which allow for a mixed moving
maxima representation. We develop an exact procedure for conditional sampling
using the Poisson point process structure of such processes. For explicit
calculations we restrict ourselves to the one-dimensional case and use a finite
number of shape functions satisfying some regularity conditions. For more
general shape functions approximation techniques are presented. Our algorithm
is applied to the Smith process and the Brown-Resnick process. Finally, we
compare our computational results to other approaches. Here, the algorithm for
Gaussian processes with transformed marginals turns out to be surprisingly
competitive.Comment: 35 pages; version accepted for publication in Extremes. The final
publication is available at http://link.springer.co
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