Right Atrial Thrombus: a Rare Presentation of Plasminogen Activator Inhibitor Deficiency

A presença de trombos móveis na aurícula direita são fenómenos raros, mas associados a uma elevada mortalidade. Apesar de a ecocardiografia ter permitido avanços no seu diagnóstico, a sua abordagem continua a ser motivo de debate. Neste artigo apresentamos o caso de uma doente do sexo feminino, de 24 anos, com antecedentes de tabagismo, obesidade e sob terapêutica anovulatória que recorre ao serviço de urgência por cansaço fácil e tosse com expetoração hemoptoica. O ecocardiograma transtorácico revelou massa, móvel, multilobulada de grandes dimensões na aurícula direita, condicionando abertura da válvula tricúspide. Perante episódios recorrentes de embolia pulmonar, foi submetida a cirurgia cardíaca com exérese da massa, sendo o resultado anatomopatológico compatível com trombo organizado com calcificação. O estudo genético revelou homozigotia para a variante alélica PAI-1:-675G >A(4G/4G) do inibidor do ativador do plasminogénio e heterozigotia para a variante alélica MTHFR 1298 A/C da 5,10-metilenotetrahidrofolato redutase

Identificação e caracterização fisiológica do soldado nas operações em áreas edificadas

No âmbito do Trabalho de Investigação Aplicada foi elaborada uma caracterização fisiológica do soldado nas operações em áreas edificadas, tendo como objetivo geral contribuir para o quadro teórico e prático na área da motricidade humana, relativamente às aptidões fisiológicas, designadamente: a Frequência Cardíaca, o Consumo de Oxigénio máximo (VO2max) e o Lactato Sanguíneo. Neste estudo foi executada uma pista de combate em áreas edificadas, com o nível de dificuldade crescente, inicialmente sem e com carga (colete balístico) de seguida com o inimigo armado com airsoft e para finalizar, a esquadra de assalto com armas de airsoft. A pista desenrolou-se na Aldeia de Camões em Mafra. Para medição dos parâmetros em estudo, utilizou os monitores cardíacos Garmin Forerunner 310XT, que fornecem os valores das Frequências Cardíacas e o Lactete Plus, que nos dão os valores dos níveis de Lactato Sanguíneo. Verificou-se que não existe uma doutrina de referência que evidencie o treino físico orientado para o combate em áreas edificadas nos dias de hoje. Da análise dos resultados obtidos verificámos que a intensidade do esforço, durante a execução das pistas de combate, foi predominantemente realizada no regime anaeróbio. Com os resultados alcançados durante a realização da pista de combate, identificámos algumas das tarefas mais críticas na sua execução. Apurámos através dos níveis de lactato que a função do comandante de esquadra é de uma intensidade de esforço físico superior a exigida na restante esquadra de assalto.Under the Applied Research Work was elaborated a physiological characterization of the soldier in the operations in built-up areas with the overall objective to contribute to the theoretical and practical framework in the area of human movement, in relation to physiological skills, namely: the heart rate, VO2max and Blood Lactate. This study performed a combat track in built-up areas, with the increasing level of difficulty initially with and without load (ballistic vest) and then with the enemy armed with airsoft and finally, the assault squad with airsoft guns. The track took place in the Camoes village in Mafra. For measurement of the parameters under study, used the heart rate monitor Garmin Forerunner 310XT, which provide the values of Heart Rate and Lactete Plus, they give the values of the levels of Lactate Blood. It was found that there is no reference doctrine showing the physical training geared for combat in built-up areas today. Analysis of the results found that the intensity of effort during the execution of combat tracks, was predominantly performed in the anaerobic regime. The results achieved during the course of the combat track, identify some of the most critical in their implementation tasks. We've found through lactate levels that the role of squad commander is an intensity of effort tax authorities than required in the remaining assault squad

Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study

© 2002 – IOS Press. All rights reserved.NO is present in the blood at 10−7 M under physiological conditions, but at concentrations higher than 10−6 M during inflammatory disease states. The aim of this study was to characterize what are the effects of these different NO concentrations on erythrocyte structural and functional properties. Blood was collected from eleven healthy men and incubated with SpermineNONOate in order to expose it during incubation time to NO concentrations between 10−7 M and 10−3 M. We measured erythrocyte aggregation and deformability, membrane lipid peroxidation and fluidity, p50, hemoglobin, oxyhemoglobin, methemoglobin concentrations and plasma pH, pO2, pCO2, Na+, K+ and Ca2+. When blood was exposed to NO 10−7 M erythrocyte deformability increase and p50 decrease. In presence of NO 10−5 M lipid fluidity and p50 decrease. When blood was exposed to NO 10−3 M methemoglobin concentration increase and erythrocyte deformability and p50 decrease but membrane fluidity and lipid peroxidation were similar to control. In conclusion, dependent of NO concentrations there is different effects on erythrocytes structural and functional properties

Nitric oxide effects on human erythrocytes structural and functional properties : an in vitro study

© 2002 – IOS Press. All rights reserved.NO is present in the blood at 10−7 M under physiological conditions, but at concentrations higher than 10−6 M during inflammatory disease states. The aim of this study was to characterize what are the effects of these different NO concentrations on erythrocyte structural and functional properties. Blood was collected from eleven healthy men and incubated with SpermineNONOate in order to expose it during incubation time to NO concentrations between 10−7 M and 10−3 M. We measured erythrocyte aggregation and deformability, membrane lipid peroxidation and fluidity, p50, hemoglobin, oxyhemoglobin, methemoglobin concentrations and plasma pH, pO2, pCO2, Na+, K+ and Ca2+. When blood was exposed to NO 10−7 M erythrocyte deformability increase and p50 decrease. In presence of NO 10−5 M lipid fluidity and p50 decrease. When blood was exposed to NO 10−3 M methemoglobin concentration increase and erythrocyte deformability and p50 decrease but membrane fluidity and lipid peroxidation were similar to control. In conclusion, dependent of NO concentrations there is different effects on erythrocytes structural and functional properties

Polyethylene glycol oligomers as siloxane modificators in consolidation of carbonate stones

Abstract The overall performance of alkoxysilanes as stone consolidants is constrained by stone mineralogy (particularly in the carbonate varieties) and by their tendency to crack during drying. In an attempt to overcome these problems, polyethylene glycol “chains” with two carboxylic acid end-groups (PEG-CA) were introduced in siloxane sols obtained by sol-gel chemistry using tetraethoxysilane (TEOS) as precursor. Different pre-condensation degrees (by varying the stirring times of sol-gel reaction: 10 min, 2, and 24 h) and PEG-CA chains with different molecular weights were studied as variables affecting the initial efficacy of the consolidants when applied into a limestone. The sol containing siloxanes with the lowest pre-condensation degree (10 min stirring) was quite susceptible to the carbonate media and thus a poor consolidation was achieved. The sol with the highest pre-condensation degree (24 h stirring) together with the PEG-CA chains with intermediate molecular weight produced significant and uniform strength gains along the stone depth. The consolidation also showed to be highly dependent on the molecular weight of the PEG-CA chains, the PEG-CA with highest molecular weight produced a non-uniform strength increase with potential harmful side effects. The results confirmed the role of carboxylic acid end-groups as efficient sol-gel catalysts and their ability to be incorporated into the silica matrix in the presence of carbonate stone.</jats:p