rHARM: Accretion and Ejection in Resistive GR-MHD

Turbulent magnetic diffusivity plays an important role for accretion disks and the launching of disk winds. We have implemented magnetic diffusivity, respective resistivity in the general relativistic MHD code HARM. This paper describes the theoretical background of our implementation, its numerical realization, our numerical tests and preliminary applications. The test simulations of the new code rHARM are compared with an analytic solution of the diffusion equation and a classical shock tube problem. We have further investigated the evolution of the magneto-rotational instability (MRI) in tori around black holes for a range of magnetic diffusivities. We find indication for a critical magnetic diffusivity (for our setup) beyond which no MRI develops in the linear regime and for which accretion of torus material to the black hole is delayed. Preliminary simulations of magnetically diffusive thin accretion disks around Schwarzschild black holes that are threaded by a large-scale poloidal magnetic field show the launching of disk winds with mass fluxes of about 50% of the accretion rate. The disk magnetic diffusivity allows for efficient disk accretion that replenishes the mass reservoir of the inner disk area and thus allows for long-term simulations of wind launching for more than 5000 time units.Comment: 21 pages, 43 figures, accepted by Ap

Dynamo action in thick disks around Kerr black holes: high-order resistive GRMHD simulations

We present the first kinematic study of an $\alpha\Omega$-dynamo in the General Relativistic Magneto-HydroDynamics (GRMHD) regime, applied to thick disks orbiting around Kerr black holes and using a fully covariant mean field dynamo closure for the Ohm law. We show that the $\alpha\Omega$-dynamo mechanism leads to a continuous exponential growth of the magnetic field within the disk and to the formation of dynamo waves drifting away or toward the equatorial plane. Since the evolution of the magnetic field occurs qualitatively in the same fashion as in the Sun, we present also butterfly diagrams that characterize our models and show the establishment of an additional timescale, which depends on the microscopic properties of the turbulent motions, possibly providing an alternative explanation to periodicities observed in many high-energy astrophysical sources where accretion onto a rotating black hole is believed to operate.Comment: 5 pages, 4 figures. Accepted for publication in MNRA

Fast reconnection in relativistic plasmas: the magnetohydrodynamics tearing instability revisited

Fast reconnection operating in magnetically dominated plasmas is often invoked in models for magnetar giant flares, for magnetic dissipation in pulsar winds, or to explain the gamma-ray flares observed in the Crab nebula, hence its investigation is of paramount importance in high-energy astrophysics. Here we study, by means of two dimensional numerical simulations, the linear phase and the subsequent nonlinear evolution of the tearing instability within the framework of relativistic resistive magnetohydrodynamics, as appropriate in situations where the Alfven velocity approaches the speed of light. It is found that the linear phase of the instability closely matches the analysis in classical MHD, where the growth rate scales with the Lundquist number S as S^-1/2, with the only exception of an enhanced inertial term due to the thermal and magnetic energy contributions. In addition, when thin current sheets of inverse aspect ratio scaling as S^-1/3 are considered, the so-called "ideal" tearing regime is retrieved, with modes growing independently on S and extremely fast, on only a few light crossing times of the sheet length. The overall growth of fluctuations is seen to solely depend on the value of the background Alfven velocity. In the fully nonlinear stage we observe an inverse cascade towards the fundamental mode, with Petschek-type supersonic jets propagating at the external Alfven speed from the X-point, and a fast reconnection rate at the predicted value R~(ln S)^-1.Comment: 14 pages, 9 figures, accepted for publication (MNRAS

Bioinspired oriented calcium phosphate nanocrystal arrays with bactericidal and osteogenic properties

The global diffusion of antibiotic resistance poses a severe threat to public health. Addressing antibiotic-resistant infections requires innovative approaches, such as antibacterial nanostructured surfaces (ANSs). These surfaces, featuring ordered arrays of nanostructures, exhibit the ability to kill bacteria upon contact. However, most currently developed ANSs utilize bioinert materials, lacking bioactivity crucial for promoting tissue regeneration, particularly in the context of bone infections. This study introduces ANSs composed of bioactive calcium phosphate nanocrystals. Two distinct ANSs were created through a biomineralization-inspired growth of amorphous calcium phosphate (ACP) precursors. The ANSs demonstrated efficient antibacterial properties against both Gram-negative (P. aeruginosa) and Gram-positive (S. aureus) antibiotic resistant bacteria, with up to 75 % mortality in adhered bacteria after only 4 h of contact. Notably, the ANS featuring thinner and less oriented nano-needles exhibited superior efficacy attributed to simultaneous membrane rupturing and oxidative stress induction. Moreover, the ANSs facilitate the proliferation of mammalian cells, enhancing adhesion, spreading, and reducing oxidative stress. The ANSs displayed also significant bioactivity towards human mesenchymal stem cells, promoting colonization and inducing osteogenic differentiation. Specifically, the ANS with thicker and more ordered nano-needles demonstrated heightened effects. In conclusion, ANSs introduced in this work have the potential to serve as foundation for developing bone graft materials capable of eradicate site infections while concurrently stimulating bone regeneration. Statement of significance: Nanostructured surfaces with antibacterial properties through a mechano-bactericidal mechanism have shown significant potential in fighting antibiotic resistance. However, these surfaces have not been fabricated with bioactive materials necessary for developing devices that are both antibacterial and able to stimulate tissue regeneration. This study demonstrates the feasibility of creating nanostructured surfaces of ordered calcium phosphate nano-needles through a biomineralization-inspired growth. These surfaces exhibit dual functionality, serving as effective bactericidal agents against Gram-negative and Gram-positive antibiotic-resistant bacteria while also promoting the proliferation of mammalian cells and inducing osteogenic differentiation of human mesenchymal stem cells. Consequently, this approach holds promise in the context of bone infections, introducing innovative nanostructured surfaces that could be utilized in the development of antimicrobial and osteogenic grafts

DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins

The huge resources that had gone into Human Immunodeficiency virus (HIV) research led to the development of potent antivirals able to suppress viral load in the majority of treated patients, thus dramatically increasing the life expectancy of people living with HIV. However, life-long treatments could result in the emergence of drug-resistant viruses that can progressively reduce the number of therapeutic options, facilitating the progression of the disease. In this scenario, we previously demonstrated that inhibitors of the human DDX3X helicase can represent an innovative approach for the simultaneous treatment of HIV and other viral infections such as Hepatitis c virus (HCV). We reported herein 6b, a novel DDX3X inhibitor that thanks to its distinct target of action is effective against HIV-1 strains resistant to currently approved drugs. Its improved in vitro ADME properties allowed us to perform preliminary in vivo studies in mice, which highlighted optimal biocompatibility and an improved bioavailability. These results represent a significant advancement in the development of DDX3X inhibitors as a novel class of broad spectrum and safe anti-HIV-1 drugs

Marx e lo Stoffwechsel: retrospettiva di un concetto e delle sue fonti

In questo testo prenderemo in esame la genesi del concetto marxiano di Stoffwechsel (metabolismo tra uomo e natura), valutando le fonti utilizzate da Marx e i pensatori che le hanno messe in luce e problematizzato il concetto. Partiremo da Alfred Schmidt e giungeremo alla letteratura più recente legata alla scuola della metabolic rift e alla rivista marxista americana Monthly Review, con particolare attenzione all'opera di John Bellamy Foster e Kohei Saito. Il nostro intento, di fronte alla crisi ecologica, è quello di dimostrare come in Marx fosse presente una seria elaborazione del rapporto tra umanità e natura, e come essa sia al centro dell'apparato categoriale marxiano dai manoscritti giovanili fino al Capitale. In this paper, we will examine the genesis of the Marxian concept of Stoffwechsel (metabolism between man and nature), evaluating the sources used by Marx and the thinkers who have highlighted and problematized this concept. We will start with Alfred Schmidt and reach the more recent literature related to the metabolic rift school and the American Marxist journal Monthly Review, with particular attention to the works of John Bellamy Foster and Kohei Saito. Our intent, in the face of the ecological crisis, is to show how a serious elaboration of the relationship between humanity and nature was present in Marx, and how it is central to the Marxian categorical apparatus from the early manuscripts through to Capital