A Gaussian process based approach for validation of multi-variable measurement systems: application to SAR measurement systems

Resource-efficient and robust validation of systems designed to measure a multi-dimensional parameter space is an unsolved problem as it would require millions of test permutations for comprehensive validation coverage. In the paper, an efficient and comprehensive validation approach based on a Gaussian Process (GP) model of the test system has been developed that can operate system-agnostically, avoids calibration to a fixed set of known validation benchmarks, and supports large configuration spaces. The approach consists of three steps that can be performed independently by different parties: 1) GP model creation, 2) model confirmation, and 3) targeted search for critical cases. It has been applied to two systems that measure specific absorption rate (SAR) for compliance testing of wireless devices and apply different SAR measurement methods: a probe-scanning system (per IEC/IEEE 62209-1528), and a static sensor-array system (per IEC 62209-3). The results demonstrate that the approach is practical, feasible, suitable for proving effective equivalence, and can be applied to any measurement method and implementation. The presented method is sufficiently general to be of value not only for SAR system validation, but also in a wide variety of applications that require critical, independent, and efficient validation

Quantum Smoluchowski equation: Escape from a metastable state

We develop a quantum Smoluchowski equation in terms of a true probability distribution function to describe quantum Brownian motion in configuration space in large friction limit at arbitrary temperature and derive the rate of barrier crossing and tunneling within an unified scheme. The present treatment is independent of path integral formalism and is based on canonical quantization procedure.Comment: 10 pages, To appear in the Proceedings of Statphys - Kolkata I

Rational Design of a Plasmid Origin That Replicates Efficiently in Both Gram-Positive and Gram-Negative Bacteria

Background: Most plasmids replicate only within a particular genus or family

Functional Fluorescent Ca(2+) Indicator Proteins in Transgenic Mice under TET Control

Genetically encoded fluorescent calcium indicator proteins (FCIPs) are promising tools to study calcium dynamics in many activity-dependent molecular and cellular processes. Great hopes—for the measurement of population activity, in particular—have therefore been placed on calcium indicators derived from the green fluorescent protein and their expression in (selected) neuronal populations. Calcium transients can rise within milliseconds, making them suitable as reporters of fast neuronal activity. We here report the production of stable transgenic mouse lines with two different functional calcium indicators, inverse pericam and camgaroo-2, under the control of the tetracycline-inducible promoter. Using a variety of in vitro and in vivo assays, we find that stimuli known to increase intracellular calcium concentration (somatically triggered action potentials (APs) and synaptic and sensory stimulation) can cause substantial and rapid changes in FCIP fluorescence of inverse pericam and camgaroo-2

Sur un cas d\u27encephaloschisis et le modelage c\ue9phalique de l\u27embryon des Mammif\ue8res

Volume: 26Start Page: 245End Page: 30