Asymptotic and Padé Approximants Methods in the Theory of Reinforced Plates and Shells

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Advantages of using authentic materials in teaching a foreign language

This paper deals with the advantages of using authentic materials in teaching a foreign language, assessing their effectiveness in developing linguistic dexterity, their ability to reproduce real-world discourse patterns, idiomatic complexity and contextual pragmatics

Use of electronic presentations in teaching a foreign language to economics students

This article deals with the advantages and expediency of using electronic presentations in teaching a foreign language to economics students. One of the important advantages of using electronic presentations is the possibility of their use in organizing independent work of economics students

Neuroinflammation, Mast Cells, and Glia: Dangerous Liaisons

The perspective of neuroinflammation as an epiphenomenon following neuron damage is being replaced by the awareness of glia and their importance in neural functions and disorders. Systemic inflammation generates signals that communicate with the brain and leads to changes in metabolism and behavior, with microglia assuming a pro-inflammatory phenotype. Identification of potential peripheral-to-central cellular links is thus a critical step in designing effective therapeutics. Mast cells may fulfill such a role. These resident immune cells are found close to and within peripheral nerves and in brain parenchyma/meninges, where they exercise a key role in orchestrating the inflammatory process from initiation through chronic activation. Mast cells and glia engage in crosstalk that contributes to accelerate disease progression; such interactions become exaggerated with aging and increased cell sensitivity to stress. Emerging evidence for oligodendrocytes, independent of myelin and support of axonal integrity, points to their having strong immune functions, innate immune receptor expression, and production/response to chemokines and cytokines that modulate immune responses in the central nervous system while engaging in crosstalk with microglia and astrocytes. In this review, we summarize the findings related to our understanding of the biology and cellular signaling mechanisms of neuroinflammation, with emphasis on mast cell-glia interactions

Dystonia type 28 with early onset (DYT-KMT2B): a clinical case

This article presents a clinical observation of a patient with a rare form of primary dystonia – type 28 dystonia associated with a heterozygous mutation in the KMT2B gene (OMIM: 617284) for the first time in the Russian literature. The disease started at the age of 6 years with unilateral dystonia of the foot, acquired the features of generalized dystonia in the 1st year from the beginning. The mutation found in proband (chr19:36229249GC>G) was not described earlier. Dystonia was insensitive to levodopa, the effect of botulinum toxin treatment was insufficient; a notable clinical result has been achieved with deep brain stimulation (DBS)

Digitalization of Higher Education During the Pandemic: Advantages and Risks

This research article presents the analysis and interpretation of the data of the authors’ study of the condition, problems and prospects of higher education digitalization at RSUH in comparison with the experience of leading foreign and Russian universities. The purpose of the article is to determine the level and features of the digitalization process of Russian higher education before, during and after the pandemic. The theoretical basis of the research is institutional and socio-cultural approaches that suggest considering the introduction of online education in the context of responding to the challenge of the formation of the digital economy and digital society. The empirical basis of the study is a survey conducted in April 2020 by the online questionnaire method, in which 327 people (representatives of the teaching staff, researchers, heads of educational departments (deans, heads of research centers), deputy heads of departments, as well as employees of deaneries, research centers and departments) took part in. Based on the generalization and interpretation of the data of the study, the authors showed that the digitalization of higher education at RSUH, as at other Russian universities, is based on the formation of an electronic information and educational environment. It appears that the evaluation of the level of access to this environment and the quality of services provided is high enough, while the effectiveness of the application needs to be improved. The introduction of electronic document management and meaningful communication with students remain the “pain points”. The causes and consequences of the impact of the pandemic on the digitalization of higher education are identified in the article. Among them: the need for new forms of student-teacher-administration communication; lack of specialized educational materials for online education; technical, methodological and psychological unpreparedness of teachers for distance education. The future belongs to mixed forms of equivalent and digital higher education. The scientific novelty of the article lies in the novelty of the comparative study of online education in Russian universities conducted by the authors (on the example of RSUH, MEPhI, NSU), as well as in the justification of the formation of hybrid (mixed) forms of higher education. Based on this study it is proposed to form a university management strategy and implement the restructuring of the educational process.В данной исследовательской статье представлены анализ и интерпретация данных проведенного авторами исследования состояния, проблем и перспектив цифровизации высшего образования в РГГУ в сравнении с опытом ведущих зарубежных и российских вузов. Цель статьи: определить уровень и особенности процесса цифровизации российского высшего образования до, в период пандемии и после нее. Теоретической основой исследования является институциональный и социокультурный подходы, предлагающие рассматривать введение онлайн-образования в контексте ответа на вызов становления цифровой экономики и цифрового общества. Эмпирическую базу составил онлайн-опрос, проведенный в апреле 2020 г. методом анкетирования, в котором приняли участие 327 человек (представители профессорско-преподавательского состава, научные сотрудники, руководители учебно-образовательных подразделений (деканы, руководители научных центров), заместители руководителей подразделений, а также сотрудники деканатов, научных центров и кафедр. На основе обобщения и интерпретации данных проведенного исследования авторы показали, что цифровизация высшего образования в РГГУ, как и в других российских вузах, идет на базе формирования электронной информационно-образовательной среды. Если оценка уровня доступа к ней и качества предоставляемых услуг достаточно высока, то эффективность применения нуждается в доработке. «Болевыми точками» остаются введение электронного документооборота и содержательная коммуникация со студентами. В статье выявлены причины и последствия влияние пандемии на цифровизацию высшего образования. Среди них – необходимость новых форм коммуникации «студент-преподаватель-администрация»; нехватка специализированных учебных материалов для онлайн-образования; техническая, методическая и психологическая неготовность преподавателей к дистанционному образованию. Будущее – за смешанными формами аналогового и цифрового высшего образования. Научная новизна статьи заключается в проведенном авторами сравнительном исследовании онлайн-образования в российских вузах (на примере РГГУ, МИФИ, НГУ), а также в обосновании становления гибридных (смешанных) форм высшего образования. На этом основании и предлагается формировать стратегию управления университетом и осуществлять перестройку учебного процесса.The authors thank all the researchers who have recently addressed the problem of changing conditions and factors affecting the technology and quality of higher education during the pandemic. In the works of these researchers the authors of the article have found authoritative support and support for their conclusions and recommendations.Авторы благодарят всех исследователей, которые в последнее время обратились к проблеме изменения условий и факторов, влияющих на технологию и качество высшего образования в период пандемии. В работах этих исследователей авторы статьи нашли авторитетную поддержку и опору для своих выводов и рекомендаций

Atypical Goodpasture’s disease: a clinical case report and literature review

Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease