The future of social is personal: the potential of the personal data store

This chapter argues that technical architectures that facilitate the longitudinal, decentralised and individual-centric personal collection and curation of data will be an important, but partial, response to the pressing problem of the autonomy of the data subject, and the asymmetry of power between the subject and large scale service providers/data consumers. Towards framing the scope and role of such Personal Data Stores (PDSes), the legalistic notion of personal data is examined, and it is argued that a more inclusive, intuitive notion expresses more accurately what individuals require in order to preserve their autonomy in a data-driven world of large aggregators. Six challenges towards realising the PDS vision are set out: the requirement to store data for long periods; the difficulties of managing data for individuals; the need to reconsider the regulatory basis for third-party access to data; the need to comply with international data handling standards; the need to integrate privacy-enhancing technologies; and the need to future-proof data gathering against the evolution of social norms. The open experimental PDS platform INDX is introduced and described, as a means of beginning to address at least some of these six challenges

E-retailing ethics in Egypt and its effect on customer repurchase intention

The theoretical understanding of online shopping behaviour has received much attention. Less focus has been given to the formation of the ethical issues that result from online shopper interactions with e-retailers. The vast majority of earlier research on this area is conceptual in nature and limited in scope by focusing on consumers’ privacy issues. Therefore, the purpose of this paper is to propose a theoretical model explaining what factors contribute to online retailing ethics and its effect on customer repurchase intention. The data were analysed using variance-based structural equation modelling, employing partial least squares regression. Findings indicate that the five factors of the online retailing ethics (security, privacy, non- deception, fulfilment/reliability, and corporate social responsibility) are strongly predictive of online consumers’ repurchase intention. The results offer important implications for e-retailers and are likely to stimulate further research in the area of e-ethics from the consumers’ perspective

Escala do comportamento do treinador: versão treinador (ECT-T) e versão atleta (ECT-A): o que o treinador diz é confirmado pelos seus atletas?

Objetivou-se verificar o nível de associação entre as percepções de atletas e treinadores de esportes coletivos e individuais nas seis dimensões do comportamento do treinador - Treinamento Físico (TF), Treinamento Técnico (TT), Preparação Mental (PM), Estabelecimento de Objetivos (EO), Reforço Pessoal Positivo (RPP), Reforço Pessoal Negativo (RPN) - acessado pela Escala do Comportamento do Treinador - Versão Treinador (ECT-T) e Versão Atleta (ECT-A). Participaram 181 atletas (114 homens e 67 mulheres) de nove modalidades esportivas com idade média de 17,15 anos (± 1,48) e seus respectivos treinadores (N = 32), todos do sexo masculino, com idade média de 32,88 (± 8,91). Treinadores e atletas responderam aos 38 itens de mesmo conteúdo dos questionários mencionados. A correlação não-paramétrica de Spearman mostrou a inexistência de associação significativa, ao nível a = 0,05, entre as percepções treinadores e atletas de modalidades coletivas nas dimensões TT, PM, EO e RPP. Entre treinadores e atletas de modalidades individuais também não foram verificadas associações significativas em cinco dimensões: TF, TT, PM, EO e RPP. Dentre outras razões, a baixa compatibilidade entre as percepções de atletas treinadores, pode estar relacionada a falhas no processo de organização do treinamento. Além disso, o relacionamento de cada treinador com os atletas sob o seu comando parece informar mais do que a simples categorização: modalidades coletivas versus individuaisThe purpose of this study was to verify the level of association between athletes and their coaches' perceptions, according to the kind of sport (individual or group), in the six dimensions of coaching behavior - Physical Training (PT); Technical Training (TT); Mental Preparation (MP); Goal Setting (GS); Personal Positive Rapport (PPR) Personal Negative Rapport (PNR) - accessed by the two Brazilian versions of Coaching Behavior Scale for Sport: Coaches (ECT-T) and Athletes Versions (ECT-A). Participated 181 athletes (114 male and 67 female) of nine different sports with mean age of 17.15 years (± 1.48) and their respective coaches (N = 32), all male, with mean age of 32.88 years (± 8.91). Coaches and athletes answered the 38 items, which have the same content, in the mentioned questionnaires. The non-parametric Spearman correlation showed the inexistence of significant association, at a level = 0.05, between the coaches and athletes perception of group sports in the dimensions TT, MP, GS and PPR. In addition, there were no significant correlations between coaches and athletes perceptions of individual sports in the following dimensions: PT, TT, MP, GS and PPR. Among others reasons, the low compatibility involving the coaches and athletes perceptions can be associated with failures in the training organization process. Besides, the relationship of each coach with their athletes appears to add more information than the simple categorization: group modalities versus individual modalitie

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Hematologic, serum biochemistry and urinary values for captive Crab-eating Fox (Cerdocyon thous) in São Paulo state, Brazil

The importance of studies with hematological, serum biochemistry and urinary values of Crab-eating Fox (Cerdocyon thous) is based on the need for health care and maintenance of those populations. This paper has the objective to investigate hematological, serum biochemistry and urinary physiological parameters of the Crab-eating fox, comparing gender and age differences. Blood samples were collected in 2003 from 52 animals of different Zoos in São Paulo state, Brazil; 7mL of blood was used to obtain a complete blood cell count (CBC) and the profile of the serum biochemistry. Moreover, 5mL of urine were collected for analysis. There was no difference in values for male and female animals, as for the CBC and serum biochemistry. Some hematological and serum biochemical parameters were influenced by age, showing significant differences. Urinalysis results were just demonstrated in a descriptive form. The studied values were, RBC 4.35±0.73 x 10(6) /µL, WBC 7.72±3.66 x 10³ /µL (predominance of segmented neutrophils), platelets 227.06±111.58 x 10³ /µL, urea 43.06±14.28mg/dL and creatinine 1.03±0.24mg/dL. Hematological, serum biochemistry and urinary values obtained in this study can be used as physiological values of the captive Crab-eating Fox. It is possible to conclude that wild species need their own reference values, differentiating animals in captivity from free-ranging animals

Targeted gene expression profiling predicts meningioma outcomes and radiotherapy responses

Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N = 1,856), including 103 meningiomas from a prospective clinical trial. The gene expression biomarker improved discrimination of outcomes compared with all other systems tested (N = 9) in the clinical validation cohort for local recurrence (5-year area under the curve (AUC) 0.81) and overall survival (5-year AUC 0.80). The increase in AUC compared with the standard of care, World Health Organization 2021 grade, was 0.11 for local recurrence (95% confidence interval 0.07 to 0.17, P P = 0.0001) and suggested postoperative management could be refined for 29.8% of patients. In sum, our results identify a targeted gene expression biomarker that improves discrimination of meningioma outcomes, including prediction of postoperative radiotherapy responses. MTG