Hydrochlorothiazide reduces urinary calcium excretion in a child with Lowe syndrome.

There is a growing recognition that children with Lowe syndrome are at risk of nephrocalcinosis and nephrolithiasis from hypercalciuria. Increased fluid intake and correction of metabolic acidosis have remained the focus for intervention but are not always successful. Thiazide diuretics, which reduce urinary calcium excretion, have not been used in these children, due to concerns that (i) they may not work as a result of the underlying tubular abnormalities and (ii) their risk may outweigh the potential benefits they have to offer. Herein we report a child with Lowe syndrome who was successfully treated with thiazides in managing his hypercalciuria

Implications of Antiphospholipid and Antineutrophilic Cytoplasmic Antibodies in the Context of Postinfectious Glomerulonephritis.

While antineutrophil cytoplasmic antibody (ANCA) positivity has been documented in some patients with postinfectious glomerulonephritis (PIGN) and is associated with more severe disease, antiphospholipid antibodies (APA) are not known to be a common occurrence. We describe a child with severe acute kidney injury who was noted to have prolonged positivity of both ANCA and APA; a renal biopsy showed noncrescentic immune complex mediated glomerulonephritis with subepithelial deposits compatible with PIGN. He recovered without maintenance immunosuppressive therapy and at last follow-up had normal renal function. We discuss the cooccurrence and implications of ANCA and APA in children with PIGN

Primary Renal Lymphoma Presenting as End-Stage Renal Disease.

Primary renal lymphoma is a rare entity, even more so in children. Children with primary renal lymphoma present with variable clinical features such as constitutional signs and symptoms, acute kidney injury, palpable abdominal masses, and gross hematuria. Herein we report a child who presented with seemingly advanced chronic kidney disease and was eventually diagnosed with primary lymphoma. He responded well to intensive chemotherapy and recovered renal function, although he was left with some functional limitations as a consequence of his treatment regimen. Our report highlights the importance of keeping neoplastic conditions under consideration when taking care of children with severe kidney disease of unclear etiology

Business Employment Dynamics: Tabulations by Employer Size

The gross job gains and gross job loss statistics from the BLS Business Employment Dynamics (BED) program measure the large gross job flows that underlie the quarterly net change in employment. In the fourth quarter of 2004, employment grew by 869,000 jobs. This growth is the sum of 8.1 million gross job gains from opening and expanding establishments, and 7.2 million gross job losses from contracting and closing establishments. The new BED data have captured the attention of economists and policymakers across the country, and these data are becoming a major contributor to our understanding of employment growth and business cycles in the U.S. economy. Following the initial release of the BED data in September 2003, the BED data series expanded in May 2004 with the release of industry statistics. The BLS then began work on tabulations by size class. The production of size-class statistics is a complex task involving several economic and statistical issues. Although it is trivial to classify a business into a size class in any given quarter, it is difficult to classify a business into a size class for a longitudinal analysis of employment growth. Several different classifications exist, and many of these possible classifications have appealing theoretical and statistical properties. Furthermore, these alternative classification methodologies result in sharply different portraits of employment growth by size class. In this article, we discuss the alternative statistical methodologies that the BLS considered for creating size class tabulations from the Business Employment Dynamics data. Our primary focus is on four methodologies: quarterly base-sizing, annual base-sizing, mean-sizing, and dynamic-sizing. We discuss the evaluation criteria that BLS considered for choosing its official size class methodology.gross job gains; gross job losses; business employment dynamics; size-class statistics; dynamic-sizing

BUILDING AN APPLICATION MODEL FOR EFFICIENT RIDE BOOKING IN RIDE-HAILING INDUSTRY

The purpose of this study is to develop an efficient ride booking application in the ride-hailing sector. The objective of the research is to provide users with an easy way to book rides at reasonable prices and convenient times. This project helps to promote the ride-hailing industry by providing guidance for the creation of real-time applications. This project answered three questions. 1. What are the technology and infrastructure requirements for developing a consolidated online application for centralized ride sharing? 2. What are other examples of application aggregators in other industries than transportation and how do they work? 3. What are the steps for developing an online application that integrates the current ride-sharing applications? This project used the Java programming language to design an Android application in Android Studio that compares different ride fares, wait time and car types. The application made use of a dummy dataset in JSON format that included time, cost, and car type details. The software allows users to enter their origin and destination, and it then presents information on availability, waiting times, estimated costs, and car types. The application development process includes the creation of the dataset, setup of the Android Studio project, data retrieval and merging using Java programming, and tabular data display on a mobile screen. The developed application helps users compare various ride-sharing services, informs riders of available ride charges, and offers estimates for wait times. It assists riders in booking the best ride among various available options across different ride-sharing platforms based on their preferences. development of an efficient ride-sharing application in the ride-hailing industry, aiming to provide users with the ability to book rides at reasonable prices and suitable times. Future developments for ride-efficiency apps include multi-language support, advanced filtering, real-time API integration, ride-sharing service growth, in-app payments, user reviews, personalized suggestions, map integration, and multi-modal growth

Bibliography of Aleyrodidae II.

Trehan und Butani veröffentlichten 1960 eine umfassende Bibliographie der Aleyrodidae, die 998 Titel enthält. Diese Arbeit wird durch den vorliegenden Artikel ergänzt.Trehan and Butani (1960) published a comprehensive bibliography listing 998 references of the Aleyrodidae. This is a supplement to that treatise

Outcomes of Kidney Transplants From Toxoplasma-Positive Donors: An Organ Procurement and Transplant Network Database Analysis.

There is a need to reconsider the acceptance of organs from donors considered suboptimal, in the absence of data. Toxoplasma antibody-positive donors (TPD) constitute one such group. The objective of our study was to compare graft survival in deceased donor renal transplant (Tx) recipients, stratified by Toxoplasma IgG status, using the Organ Procurement and Transplantation Network (OPTN) database. A log-linear event history regression model for graft failure categorized by Toxoplasma IgG status, adjusting for confounders was applied to first kidney-only Tx recipients from 2018 to 2022. Of the 51,422 Tx, 4,317 (8.4%) were from TPD. Acute rejection and graft failure (5% each) were similar between groups. Crude graft failure was 7.3 failures per 100 person-years for TPD recipients compared to 6.5 failures per 100 person-years for the Toxoplasma-negative group (p 0.008). The crude failure rate ratio was 1.14 with an adjusted hazard rate ratio of 1.04 (95% CI: 0.94, 1.15, p 0.39). In renal Tx recipients, TPD graft recipients have comparable survival to Tx from Toxoplasma-negative recipients. While caution and close monitoring of recipients post-Tx for surveillance of disseminated toxoplasmosis are still warranted, our study suggests that patients can be successfully managed using TPD organs

STUDIES IN OXCARBAZEPINE MICROSPHERES EMPLOYING PLACKETT AND BURMAN DESIGN

Objective: The present work was aimed to screen material and processing parameters affecting encapsulation efficiency and drug release from microspheres. Methods: Oxcarbazepine loaded microspheres were prepared employing multiple emulsion solvent evaporation technique. Ratio of chitosan to ethyl cellulose, ratio of drug to polymer, stirring speed, ratio of dichloromethane to methanol, amount of Span 80 and the volume of aqueous phase were selected as independent variables in the Plackett and Burman design. The microspheres were characterized for percentage yield, percentage encapsulation efficiency, particle size distribution and in vitro drug release. Results: The critical material and processing parameters affecting encapsulation efficiency were chitosan to ethyl cellulose ratio, volume of water, stirring speed and drug to polymer ratio. Initial burst release was affected by volume of water, temperature, dichloromethane to methanol ratio, amount of Span 80 and drug to polymer ratio. FTIR study showed compatibility of the drug with excipients. Conclusion: The outcome of the study shall be used to calculate risk priority number (RPN) and for devising suitable control strategies for the critical factors at industry