Masters of War

Throughout the last decade, defenders of the US role in Vietnam have argued that America's defeat was not the result of an illegitimate intervention or military shortcomings but rather a failure of will because national leaders, principally Lyndon B. Johnson, forced the troops to 'fight with one hand tied behind their backs.' In this volume, Robert Buzzanco disproves this theory by demonstrating that political leaders, not the military brass, pressed for war; that American policymakers always understood the problems and peril of war in Indochina; and that civil-military acrimony and the political desire to defer responsibility for Vietnam helped lead the United States into the war. For the first time, these crucial issues of military dissent, interservice rivalries, and civil-military relations and politics have been tied together to provide a cogent and comprehensive analysis of the US role in Vietnam.</jats:p

Proinflammatory IgG Fc structures in patients with severe COVID-19

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections can cause Coronavirus Disease 2019 (COVID-19), which manifests with a range of severities from mild illness to life threatening pneumonia and multi-organ failure. Severe COVID-19 is characterized by an inflammatory signature including high levels of inflammatory cytokines, alveolar inflammatory infiltrates and vascular microthrombi. Here we show that severe COVID-19 patients produced a unique serologic signature, including increased IgG1 with afucosylated Fc glycans. This Fc modification on SARS-CoV-2 IgGs enhanced interactions with the activating FcγR, FcγRIIIa; when incorporated into immune complexes, Fc afucosylation enhanced production of inflammatory cytokines by monocytes, including IL-6 and TNF. These results show that disease severity in COVID-19 correlates with the presence of afucosylated IgG1, a pro-inflammatory IgG Fc modification.</jats:p