Organic versus conventional dairy farming – studies from the Öjebyn Project

This report was presented at the UK Organic Research 2002 Conference. A study (the Öjebyn Project) was conducted to determine differences between organic and conventional dairy farming systems. Comparisons of feed intake, milk production, live weight (LW), feed efficiency and animal health were conducted, based on records from 145 dairy cows (238 parities). A lower daily metabolisable energy (ME) intake, lower milk yield and a higher protein content were recorded in the organic herd during the first ten weeks of lactation. No differences were recorded between the systems in either average total DM intake or efficiency of feed conversion, calculated as MJ of feed/kg of energy-corrected milk (ECM). There were a trend to lower LW change and better health in the organic herd. Most differences between the systems were recorded during the early lactation period

CONTRACTING FOR NONPOINT-SOURCE POLLUTION ABATEMENT

This study presents an incentive scheme to control agricultural nonpoint-source pollution. The analysis is based on a principal-agent framework with two parties: farmers and a regulating authority. Our incentive scheme proposes collective penalties as a way to control pollution. Unlike previous analyses of incentive schemes to control agricultural pollution, we suggest nonindividual contracts between farmers and a regulating authority, where farmers can trade pollution abatement efforts. Findings show that the information requirement of a regulatory agency can be substantially reduced if contracts can be made nonindividual.Environmental Economics and Policy,

Architecture and Access: Navigating A New Space

Pacific Northwest College of Art (PNCA) is a small, private art and design college founded in 1909. PNCA is located in downtown Portland and hosts approximately 600 students in ten undergraduate programs and five graduate programs. In January 2015, the campus was moved from our old building — a converted warehouse — to the Arlene and Harold Schnitzer Center for Art and Design, a former federal building located on Portland’s North Park Blocks in the heart of the city. This move almost doubled the square footage of the library, affording us more space for our collection, three new study rooms, a reference desk, a built-in IT help desk, and more seating and workspace for our patrons. Like any new space, however, the Albert Solheim Library required many adjustments, both in our approach to access services and in the usage and layout of the space itself

Structure and non-essential function of glycerol kinase in <i>Plasmodium</i> <i>falciparum</i> blood stages

Malaria pathology is caused by multiplication of asexual parasites within erythrocytes, whereas mosquito transmission of malaria is mediated by sexual precursor cells (gametocytes). Microarray analysis identified glycerol kinase (GK) as the second most highly upregulated gene in Plasmodium falciparum gametocytes with no expression detectable in asexual blood stage parasites. Phosphorylation of glycerol by GK is the rate-limiting step in glycerol utilization. Deletion of this gene from P. falciparum had no effect on asexual parasite growth, but surprisingly also had no effect on gametocyte development or exflagellation, suggesting that these life cycle stages do not utilize host-derived glycerol as a carbon source. Kinetic studies of purified PfGK showed that the enzyme is not regulated by fructose 1,6 bisphosphate. The high-resolution crystal structure of P. falciparum GK, the first of a eukaryotic GK, reveals two domains embracing a capacious ligand-binding groove. In the complexes of PfGK with glycerol and ADP, we observed closed and open forms of the active site respectively. The 27° domain opening is larger than in orthologous systems and exposes an extensive surface with potential for exploitation in selective inhibitor design should the enzyme prove to be essential in vivo either in the human or in the mosquito

Importance of coastal primary production in the northern Baltic Sea

In this study, we measured depth-dependent benthic microalgal primary production in a Bothnian Bay estuary to estimate the benthic contribution to total primary production. In addition, we compiled data on benthic microalgal primary production in the entire Baltic Sea. In the estuary, the benthic habitat contributed 17 % to the total annual primary production, and when upscaling our data to the entire Bothnian Bay, the corresponding value was 31 %. This estimated benthic share (31 %) is three times higher compared to past estimates of 10 %. The main reason for this discrepancy is the lack of data regarding benthic primary production in the northern Baltic Sea, but also that past studies overestimated the importance of pelagic primary production by not correcting for system-specific bathymetric variation. Our study thus highlights the importance of benthic communities for the northern Baltic Sea ecosystem in general and for future management strategies and ecosystem studies in particular.Peer reviewe

Ischemic preconditioning modulates ROS to confer protection in liver ischemia and reperfusion

Ischemia reperfusion (IR) injury is a significant cause of morbidity and mortality in liver transplantation. When oxygen is reintroduced to the liver graft it initiates a cascade of molecular reactions leading to the release of reactive oxygen species (ROS) and pro-inflammatory cytokines. These soluble mediators propagate a sterile immune response to cause significant tissue damage. Ischemic preconditioning (IPC) is one method that reduces hepatocellular injury by altering the immune response and inhibiting the production of ROS. Studies quantifying the effects of IPC in humans have demonstrated an improved liver enzyme panel in patients receiving grafts pretreated with IPC as compared to patients receiving the standard of care. In our review, we explore current literature in the field in order to describe the mechanism through which IPC regulates the production of ROS and improves IR injury

Favorable therapeutic response of osteoporosis patients to treatment with intravenous zoledronate compared with oral alendronate

Objectives: To evaluate the efficacy of orally-administered alendronate compared with intravenously-administered zoledronate. Methods: This prospective study was carried out at Barts Health HNS Trust between April 2010 and March 2012. This study compares changes in bone mineral density (BMD) in 234 patients treated with 2 bisphosphonates: alendronate taken orally, and zoledronate administered intravenously. One hundred and eighteen patients received alendronate at 70 mg/week, while 116 patients received zoledronate once annually. Dual energy x-ray absorptiometry was used to measure BMD of the left hip and anterior-posterior spine (lumbar L1-L4) skeletal sites at baseline, and at one-, and 2-years post-treatment. Results: This study provides evidence that lumbar spine BMD increased by 3.6% in patients receiving alendronate, and 5.7% in patients receiving zoledronate after 2 years compared with baseline values (p=0.0001 for both). Total hip BMD decreased in patients treated with alendronate by 0.4% but increased in patients receiving zoledronate by 0.8% (p=0.0001). Conclusion: This study provides evidence that zoledronate is more effective than alendronate in treating patients with osteoporosis and with no gastrointestinal (GI) serious side effects. Furthermore, zoledronate appears to have the added advantage of a better safety profile in patients suffering from GI intolerance of oral bisphosphonates

Th17 Lymphocytes in Respiratory Syncytial Virus Infection

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution licenseStudies of the role of IL-17 in arthritis carried out in our laboratory are generously supported by a research grant from Pfizer