Heterosensory and Heterocortical Activation of the Purkinje Neuron

Bioelectric potential measurements of convergence of heterogeneous afferents at single neuron level in cerebellar corte

Financial Information Mediation: A Case Study of Standards Integration for Electronic Bill Presentment and Payment Using the COIN Mediation Technology

Each player in the financial industry, each bank, stock exchange, government agency, or insurance company operates its own financial information system or systems. By its very nature, financial information, like the money that it represents, changes hands. Therefore the interoperation of financial information systems is the cornerstone of the financial services they support. E-services frameworks such as web services are an unprecedented opportunity for the flexible interoperation of financial systems. Naturally the critical economic role and the complexity of financial information led to the development of various standards. Yet standards alone are not the panacea: different groups of players use different standards or different interpretations of the same standard. We believe that the solution lies in the convergence of flexible E-services such as web-services and semantically rich meta-data as promised by the semantic Web; then a mediation architecture can be used for the documentation, identification, and resolution of semantic conflicts arising from the interoperation of heterogeneous financial services. In this paper we illustrate the nature of the problem in the Electronic Bill Presentment and Payment (EBPP) industry and the viability of the solution we propose. We describe and analyze the integration of services using four different formats: the IFX, OFX and SWIFT standards, and an example proprietary format. To accomplish this integration we use the COntext INterchange (COIN) framework. The COIN architecture leverages a model of sources and receivers’ contexts in reference to a rich domain model or ontology for the description and resolution of semantic heterogeneity.Singapore-MIT Alliance (SMA

The impact of a structured exercise program on the pre-established exercise goals for individuals with disabilities

This study aimed to identify the efficacy of a structured exercise program emphasizing family involvement and self-determination theory in meeting pre-established fitness goals for adults with disabilities. To measure physical strength and endurance changes, the 6-minute walk test, the curl-up, and push-up tests were utilized. A single-subject changing-criterion design was used in this study over the course of six weeks. Results indicated a positive relationship between the intervention and increased physical strength and endurance, according to testing results. Few participants met the criterion for each phase. However, many did demonstrate an increase in the distance walked, push-ups, and curl-ups completed in each phase. This study may be of importance in providing a reference for an intervention that may lead to a decrease in sedentary behavior and further support for adults with disabilities and their families in accessing resources and opportunities for physical activity

Greedy Rectilinear Drawings

A drawing of a graph is greedy if for each ordered pair of vertices u and v, there is a path from u to v such that the Euclidean distance to v decreases monotonically at every vertex of the path. The existence of greedy drawings has been widely studied under different topological and geometric constraints, such as planarity, face convexity, and drawing succinctness. We introduce greedy rectilinear drawings, in which each edge is either a horizontal or a vertical segment. These drawings have several properties that improve human readability and support network routing. We address the problem of testing whether a planar rectilinear representation, i.e., a plane graph with specified vertex angles, admits vertex coordinates that define a greedy drawing. We provide a characterization, a linear-time testing algorithm, and a full generative scheme for universal greedy rectilinear representations, i.e., those for which every drawing is greedy. For general greedy rectilinear representations, we give a combinatorial characterization and, based on it, a polynomial-time testing and drawing algorithm for a meaningful subset of instances.Comment: Appears in the Proceedings of the 26th International Symposium on Graph Drawing and Network Visualization (GD 2018

The Genetic Structure and History of Africans and African Americans.

Africa is the source of all modern humans, but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We studied 121 African populations, four African American populations, and 60 non-African populations for patterns of variation at 1327 nuclear microsatellite and insertion/deletion markers. We identified 14 ancestral population clusters in Africa that correlate with self-described ethnicity and shared cultural and/or linguistic properties. We observed high levels of mixed ancestry in most populations, reflecting historical migration events across the continent. Our data also provide evidence for shared ancestry among geographically diverse hunter-gatherer populations (Khoesan speakers and Pygmies). The ancestry of African Americans is predominantly from Niger-Kordofanian (approximately 71%), European (approximately 13%), and other African (approximately 8%) populations, although admixture levels varied considerably among individuals. This study helps tease apart the complex evolutionary history of Africans and African Americans, aiding both anthropological and genetic epidemiologic studies

DMN for Data Quality Measurement and Assessment

Data Quality assessment is aimed at evaluating the suitability of a dataset for an intended task. The extensive literature on data quality describes the various methodologies for assessing data quality by means of data profiling techniques of the whole datasets. Our investigations are aimed to provide solutions to the need of automatically assessing the level of quality of the records of a dataset, where data profiling tools do not provide an adequate level of information. As most of the times, it is easier to describe when a record has quality enough than calculating a qualitative indicator, we propose a semi-automatically business rule-guided data quality assessment methodology for every record. This involves first listing the business rules that describe the data (data requirements), then those describing how to produce measures (business rules for data quality measurements), and finally, those defining how to assess the level of data quality of a data set (business rules for data quality assessment). The main contribution of this paper is the adoption of the OMG standard DMN (Decision Model and Notation) to support the data quality requirement description and their automatic assessment by using the existing DMN engines.Ministerio de Ciencia y Tecnología RTI2018-094283-B-C33Ministerio de Ciencia y Tecnología RTI2018-094283-B-C31European Regional Development Fund SBPLY/17/180501/00029

Towards certain fixes with editing rules and master data

A variety of integrity constraints have been studied for data cleaning. While these constraints can detect the presence of errors, they fall short of guiding us to correct the errors. Indeed, data repairing based on these constraints may notfind certain fixes that are absolutely correct, and worse, may introduce new errors when repairing the data. We propose a method for finding certain fixes, based on master data, a notion of certain regions, and a class of editing rules. A certain region is a set of attributes that are assured correct by the users. Given a certain region and master data, editing rules tell us what attributes to fix and how to update them. We show how the method can be used in data monitoring and enrichment. We develop techniques for reasoning about editing rules, to decide whether they lead to a unique fix and whether they are able to fix all the attributes in a tuple, relative to master data and a certain region. We also provide an algorithm to identify minimal certain regions, such that a certain fix is warranted by editing rules and master data as long as one of the regions is correct. We experimentally verify the effectiveness and scalability of the algorithm

Qualtra Geothermal Power Plant: Life Cycle, Exergo-Economic, and Exergo-Environmental Preliminary Assessment

Qualtra, an innovative 10 MW geothermal power plant proposal, employs a closed-loop design to mitigate emissions, ensuring no direct release into the atmosphere. A thorough assessment utilizing energy and exergy analysis, life cycle assessment (LCA), exergo-economic analysis, and exergo environmental analysis (EevA) was conducted. The LCA results, utilizing the ReCiPe 2016 midpoint methodology, encompass all the spectrum of environmental indicators provided. The technology implemented makes it possible to avoid direct atmospheric emissions from the Qualtra plant, so the environmental impact is mainly due to indirect emissions over the life cycle. The result obtained for the global warming potential indicator is about 6.6 g CO2 eq/kWh, notably lower compared to other conventional systems. Contribution analysis reveals that the construction phase dominates, accounting for over 90% of the impact for almost all LCA midpoint categories, excluding stratospheric ozone depletion, which is dominated by the impact from the operation and maintenance phase, at about 87%. Endpoint indicators were assessed to estimate the single score value using normalization and weighting at the component level. The resulting single score is then used in an Exergo-Environmental Analysis (EEvA), highlighting the well system as the most impactful contributor, constituting approximately 45% of the total impact. Other substantial contributions to the environmental impact include the condenser (21%), the turbine (17%), and the HEGeo (14%). The exergo-economic analysis assesses cost distribution across major plant components, projecting an electricity cost of about 9.4 c€/kWh

Recombination dynamics of a human Y-chromosomal palindrome:rapid GC-biased gene conversion, multi-kilobase conversion tracts, and rare inversions

The male-specific region of the human Y chromosome (MSY) includes eight large inverted repeats (palindromes) in which arm-to-arm similarity exceeds 99.9%, due to gene conversion activity. Here, we studied one of these palindromes, P6, in order to illuminate the dynamics of the gene conversion process. We genotyped ten paralogous sequence variants (PSVs) within the arms of P6 in 378 Y chromosomes whose evolutionary relationships within the SNP-defined Y phylogeny are known. This allowed the identification of 146 historical gene conversion events involving individual PSVs, occurring at a rate of 2.9-8.4×10(-4) events per generation. A consideration of the nature of nucleotide change and the ancestral state of each PSV showed that the conversion process was significantly biased towards the fixation of G or C nucleotides (GC-biased), and also towards the ancestral state. Determination of haplotypes by long-PCR allowed likely co-conversion of PSVs to be identified, and suggested that conversion tract lengths are large, with a mean of 2068 bp, and a maximum in excess of 9 kb. Despite the frequent formation of recombination intermediates implied by the rapid observed gene conversion activity, resolution via crossover is rare: only three inversions within P6 were detected in the sample. An analysis of chimpanzee and gorilla P6 orthologs showed that the ancestral state bias has existed in all three species, and comparison of human and chimpanzee sequences with the gorilla outgroup confirmed that GC bias of the conversion process has apparently been active in both the human and chimpanzee lineages

60,000 years of interactions between Central and Eastern Africa documented by major African mitochondrial haplogroup L2

Mitochondrial DNA (mtDNA) haplogroup L2 originated in Western Africa but is nowadays spread across the entire continent. L2 movements were previously postulated to be related to the Bantu expansion, but L2 expansions eastwards probably occurred much earlier. By reconstructing the phylogeny of L2 (44 new complete sequences) we provide insights on the complex net of within-African migrations in the last 60 thousand years (ka). Results show that lineages in Southern Africa cluster with Western/Central African lineages at a recent time scale, whereas, eastern lineages seem to be substantially more ancient. Three moments of expansion from a Central African source are associated to L2: (1) one migration at 70-50 ka into Eastern or Southern Africa, (2) postglacial movements (15-10 ka) into Eastern Africa; and (3) the southward Bantu Expansion in the last 5 ka. The complementary population and L0a phylogeography analyses indicate no strong evidence of mtDNA gene flow between eastern and southern populations during the later movement, suggesting low admixture between Eastern African populations and the Bantu migrants. This implies that, at least in the early stages, the Bantu expansion was mainly a demic diffusion with little incorporation of local populations.This research received support from the European project “A European Initial Training Network on the History, Archaeology, and New Genetics of the Trans-Atlantic Slave Trade (EUROTAST)” (EU project: 290344). PSo is supported by FCT (the Portuguese Foundation for Science and Technology), European Social Fund, Programa Operacional Potencial Humano and the FCT Investigator Programme (IF/01641/2013). IPATIMUP integrates the i3S Research Unit, which is partially supported by FCT. This work is funded by FEDER funds through the Operational Programme for Competitiveness FactorsCOMPETE and National Funds through FCT, under the project “PEst-C/SAU/LA0003/2013”. FCT/MEC supports CBMA through Portuguese funds (PIDDAC) - PEst-OE/BIA/UI4050/2014. NORTE-07-0162FEDER-00018 (Contributos para o reforço da capacidade do IPATIMUP enquanto actor do sistema regional de inovação) and NORTE-07-0162-FEDER-000067 (Reforço e consolidação da capacidade infraestrutural do IPATIMUP para o sistema regional de inovação), both supported by Programa Operacional Regional do Norte (ON.2 – O Novo Norte), through FEDER funds under the Quadro de Referência Estratégico Nacional (QREN)