Laser-induced substructures in above-threshold-ionization spectra from intense few-cycle laser pulses

We have calculated above-threshold-ionization (ATI) spectra for argon in a strong, few-cycle 400 nm laser pulse with an ab initio solution of the time-dependent Schrödinger equation and by using a model based on the strong field approximation. We find additional peaks in the resulting ATI spectra which are not present for longer pulses. This substructure is due to the rapidly changing ponderomotive potential in the short laser pulse. It is sensitive to the pulse duration and the pulse envelope and is a general feature of ionization spectra originating from a short, intense laser pulse

Analysis of two-dimensional photoelectron momentum spectra and the effect of the long-range Coulomb potential in single ionization of atoms by intense lasers

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Signatures of tunneling and multiphoton ionization in the electron-momentum distributions of atoms by intense few-cycle laser pulses

Electron-momentum distributions for above-threshold ionization of argon in a few-cycle, linearly polarized laser pulse are investigated. Spectral features characteristic of multiphoton as well as tunneling ionization coexist over a range of the Keldysh parameter gamma in the transition regime gamma~1. Surprisingly, the simple strong-field approximation (SFA) is capable of reproducing the key features of the two-dimensional momentum distributions found in the full solution of the time-dependent Schrödinger equation, despite the fact that SFA is known to severely underestimate the total ionization probability

The Energy-Momentum Tensor in Noncommutative Gauge Field Models

We discuss the different possibilities of constructing the various energy-momentum tensors for noncommutative gauge field models. We use Jackiw's method in order to get symmetric and gauge invariant stress tensors--at least for commutative gauge field theories. The noncommutative counterparts are analyzed with the same methods. The issues for the noncommutative cases are worked out.Comment: 11 pages, completed reference

Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma

BACKGROUND: Changes in the tumor microenvironment and immune surveillance represent crucial hallmarks of various kinds of cancer, including oral squamous cell carcinoma (OSCC), and a close crosstalk of hypoxia regulating genes, an activation of chemokines and immune cells has been described. METHODS: A review about the pivotal role of HIF-1, its crosstalk to various cornerstones in OSCC tumorigenesis is presented. RESULTS: Hypoxia is a frequent event in OSCC and leads to a reprogramming of the cellular metabolism in order to prevent cell death. Hypoxic OSCC cells induce different adaptive changes such as anaerobic glycolysis, pH stabilisation and alterations of the gene and protein expression profile. This complex metabolic program is orchestrated by the hypoxia inducible factor (HIF)-1, the master regulator of early tumor progression. Hypoxia-dependent and -independent alterations in immune surveillance lead to different immune evasion strategies, which are partially mediated by alterations of the tumor cells, changes in the frequency, activity and repertoire of immune cell infiltrates and of soluble and environmental factors of the tumor micromilieu with consecutive generation of an immune escape phenotype, progression of disease and poor clinical outcome of OSCC patients. CONCLUSIONS: This review focusses on the importance of HIF-1 in the adaption and reprogramming of the metabolic system to reduced oxygen values as well as on the role of the tumor microenvironment for evasion of OSCC from immune recognition and destruction

Analysis of Two-Dimensional Photoelectron Momentum Spectra and the Effect of the Long-Range Coulomb Potential in Single Ionization of Atoms by Intense Lasers

Two-dimensional (2D) electron momentum distributions and energy spectra for multiphoton ionization of atoms by intense laser pulses, calculated by solving the time-dependent Schrödinger equation (TDSE) for different wavelengths and intensities, are compared to those predicted by the strong-field approximation (SFA). It is shown that the momentum spectra at low energies between the TDSE and SFA are quite different and the differences arise largely from the absence of a long-range Coulomb interaction in the SFA. We further found that the low-energy 2D momentum spectra from the TDSE exhibit ubiquitous fanlike features where the number of stripes is due to a single dominant angular momentum of the low-energy electron. The specific dominant angular momentum in turn has been found to be decided by the minimum number of photons needed to ionize the atom only. The electron momentum spectra predicted by models modified from the SFA are also examined and found to lack the fanlike features as in the SFA

Hydronephrosis Resulting from Bilateral Ureteral Stenosis: A Late Complication of Polyoma BK Virus Cystitis?

We report here a case of acute lymphoblastic leukemia in remission presenting a late-onset bilateral hydronephrosis probably due to polyoma BK virus-induced proliferation of bladder endothelium on both ostii. The diagnosis was made virologically by BK virus Polymerase Chain Reaction (PCR) detection in the absence of any other bladder disease. Awareness of this late complication is necessary not only in patients after renal transplantation but also in patients after hematopoietic stem cell transplantation from matched unrelated donor

Bilaterale inflammatorische idiopathische Orbitopathie und chronische Sinusitis : eine IgG4-assoziierte Erkrankung?

Publikationsfonds ML

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

Given the plasticity of hematopoietic stem and progenitor cells, multiple routes of differentiation must be blocked in the the pathogenesis of acute myeloid leukemia, the molecular basis of which is incompletely understood. We report that posttranscriptional repression of the transcription factor ARID3A by miR-125b is a key event in the pathogenesis of acute megakaryoblastic leukemia (AMKL). AMKL is frequently associated with trisomy 21 and GATA1 mutations (GATA1s), and children with Down syndrome are at a high risk of developing the disease. The results of our study showed that chromosome 21-encoded miR-125b synergizes with Gata1s to drive leukemogenesis in this context. Leveraging forward and reverse genetics, we uncovered Arid3a as the main miR-125b target behind this synergy. We demonstrated that, during normal hematopoiesis, this transcription factor promotes megakaryocytic differentiation in concert with GATA1 and mediates TGFβ-induced apoptosis and cell cycle arrest in complex with SMAD2/3. Although Gata1s mutations perturb erythroid differentiation and induce hyperproliferation of megakaryocytic progenitors, intact ARID3A expression assures their megakaryocytic differentiation and growth restriction. Upon knockdown, these tumor suppressive functions are revoked, causing a blockade of dual megakaryocytic/erythroid differentiation and subsequently of AMKL. Inversely, restoring ARID3A expression relieves the arrest of megakaryocytic differentiation in AMKL patient-derived xenografts. This work illustrates how mutations in lineage-determining transcription factors and perturbation of posttranscriptional gene regulation can interact to block multiple routes of hematopoietic differentiation and cause leukemia. In AMKL, surmounting this differentiation blockade through restoration of the tumor suppressor ARID3A represents a promising strategy for treating this lethal pediatric disease