40,495 research outputs found

    Off-equilibrium corrections to energy and conserved charge densities in the relativistic fluid in heavy-ion collisions

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    Dissipative processes in relativistic fluids are known to be important in the analyses of the hot QCD matter created in high-energy heavy-ion collisions. In this work, I consider dissipative corrections to energy and conserved charge densities, which are conventionally assumed to be vanishing but could be finite. Causal dissipative hydrodynamics is formulated in the presence of those dissipative currents. The relation between hydrodynamic stability and transport coefficients is discussed. I then study their phenomenological consequences on the observables of heavy-ion collisions in numerical simulations. It is shown that particle spectra and elliptic flow can be visibly modified.Comment: 10 pages, 5 figures; title changed, references added, conclusions unchange

    Leading interactions in the β\beta-SrV6O15Sr V_6 O_{15} compound

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    The present study shows that the electronic structure of the β\beta-AV_6O_15AV\_6O\_{15} family of compounds (A=Sr,Ca,Na...A = Sr, Ca, Na ...) is based on weakly interacting two-leg ladders, in contrast with the zig-zag chain model one could expect from their crystal structure. Spin dimer analysis, based on extended H\"{u}ckel tight-binding calculations, was performed to determine the structure of the dominant transfer and magnetic interactions in the room temperature β\beta-SrV_6O_15SrV\_6O\_{15} phase. Two different two-legs ladders, associated with different charge/spin orders are proposed to describe these one-dimensional β\beta-type systems. The antiferromagnetic ladders are packed in an 'IPN' geometry and coupled to each other through weak antiferromagnetic interactions. This arrangement of the dominant interactions explains the otherwise surprising similarities of the optical conductivity and Raman spectra for the one-dimensional β\beta-type phases and the two-dimensional α\alpha-type ones such as the well-known α\alpha^\prime-NaV_2O_5NaV\_2O\_5 system

    Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy.

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    Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver failure (ALF). We discuss the diagnosis of HLH and Kikuchi-Fujimoto (KF) lymphadenitis in the context of pregnancy and ALF. HLH may respond to comorbid disease-specific therapy, and more toxic treatment can be avoided

    Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism

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    Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention

    Cavallo's Multiplier for in situ Generation of High Voltage

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    A classic electrostatic induction machine, Cavallo's multiplier, is suggested for in situ production of very high voltage in cryogenic environments. The device is suitable for generating a large electrostatic field under conditions of very small load current. Operation of the Cavallo multiplier is analyzed, with quantitative description in terms of mutual capacitances between electrodes in the system. A demonstration apparatus was constructed, and measured voltages are compared to predictions based on measured capacitances in the system. The simplicity of the Cavallo multiplier makes it amenable to electrostatic analysis using finite element software, and electrode shapes can be optimized to take advantage of a high dielectric strength medium such as liquid helium. A design study is presented for a Cavallo multiplier in a large-scale, cryogenic experiment to measure the neutron electric dipole moment.Comment: 9 pages, 10 figure

    Decision aids can support cancer clinical trials decisions: Results of a randomized trial

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    BACKGROUND. Cancer patients often do not make informed decisions regarding clinical trial participation. This study evaluated whether a web-based decision aid (DA) could support trial decisions compared with our cancer center’s website. METHODS. Adults diagnosed with cancer in the past 6 months who had not previously participated in a cancer clinical trial were eligible. Participants were randomized to view the DA or our cancer center’s website (enhanced usual care [UC]). Controlling for whether participants had heard of cancer clinical trials and educational attainment, multivariable linear regression examined group on knowledge, self-efficacy for finding trial information, decisional conflict (values clarity and uncertainty), intent to participate, decision readiness, and trial perceptions. RESULTS. Two hundred patients (86%) consented between May 2014 and April 2015. One hundred were randomized to each group. Surveys were completed by 87 in the DA group and 90 in the UC group. DA group participants reported clearer values regarding trial participation than UC group participants reported (least squares [LS] mean = 15.8 vs. 32, p < .0001) and less uncertainty (LS mean = 24.3 vs. 36.4, p = .025). The DA group had higher objective knowledge than the UC group’s (LS mean = 69.8 vs. 55.8, p < .0001). There were no differences between groups in intent to participate. CONCLUSIONS. Improvements on key decision outcomes including knowledge, self-efficacy, certainty about choice, and values clarity among participants who viewed the DA suggest web-based DAs can support informed decisions about trial participation among cancer patients facing this preference-sensitive choice. Although better informing patients before trial participation could improve retention, more work is needed to examine DA impact on enrollment and retention. IMPLICATIONS FOR PRACTICE: This paper describes evidence regarding a decision tool to support patients’ decisions about trial participation. By improving knowledge, helping patients clarify preferences for participation, and facilitating conversations about trials, decision aids could lead to decisions about participation that better match patients’ preferences, promoting patient-centered care and the ethical conduct of clinical research

    Atomic interferometer measurements of Berry's and Aharonov-Anandan's phases for isolated spins S > 1/2 non-linearly coupled to external fields

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    The aim of the present paper is to propose experiments for observing the significant features of Berry's phases for S>1, generated by spin-Hamiltonians endowed with two couplings, a magnetic dipole and an electric quadrupole one with external B and E fields, as theoretically studied in our previous work. The fields are assumed orthogonal, this mild restriction leading to geometric and algebraic simplifications. Alkali atoms appear as good candidates for interferometric measurements but there are challenges to be overcome. The only practical way to generate a suitable E-field is to use the ac Stark effect which induces an instability of the dressed atom. Besides atom loss, this might invalidate Berry's phase derivation but this latter problem can be solved by an appropriate detuning. The former puts an upper limit to the cycle duration, which is bounded below by the adiabatic condition. By relying upon our previous analysis of the non-adiabatic corrections, we have been able to reach a compromise for the 87^{87}Rb hf level F=2, m=0 state, which is our candidate for an interferometric measurement of the exotic Berry's phase generated by a rotation of the E-field around the fixed B-field. By a numerical simulation we have shown that the non-adiabatic corrections can be kept below the 0.1% level. As an alternative candidate, we discuss the chromium ground state J=S=3, where the instability problem is easily solved. We make a proposal to extend the measurement of Aharonov-Anandan's phase beyond S=1/2 to the 87^{87}Rb hf level F=m=1, by constructing, with the help of light-shifts, a Hamiltonian able to perform a parallel transport along a closed circuit upon the density matrix space, without any adiabatic constraint. In Appendix A, Berry's phase difference for S=3/2 and 1/2, m=1/2 states is used to perform an entanglement of 3 Qbits.Comment: 23 pages, 6 figures, modifications in the introduction, two paragraphs adde

    Exploration of finite dimensional Kac algebras and lattices of intermediate subfactors of irreducible inclusions

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    We study the four infinite families KA(n), KB(n), KD(n), KQ(n) of finite dimensional Hopf (in fact Kac) algebras constructed respectively by A. Masuoka and L. Vainerman: isomorphisms, automorphism groups, self-duality, lattices of coideal subalgebras. We reduce the study to KD(n) by proving that the others are isomorphic to KD(n), its dual, or an index 2 subalgebra of KD(2n). We derive many examples of lattices of intermediate subfactors of the inclusions of depth 2 associated to those Kac algebras, as well as the corresponding principal graphs, which is the original motivation. Along the way, we extend some general results on the Galois correspondence for depth 2 inclusions, and develop some tools and algorithms for the study of twisted group algebras and their lattices of coideal subalgebras. This research was driven by heavy computer exploration, whose tools and methodology we further describe.Comment: v1: 84 pages, 13 figures, submitted. v2: 94 pages, 15 figures, added connections with Masuoka's families KA and KB, description of K3 in KD(n), lattices for KD(8) and KD(15). v3: 93 pages, 15 figures, proven lattice for KD(6), misc improvements, accepted for publication in Journal of Algebra and Its Application

    Housing Subsidies: A Closer Look at the Issues

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    To improve poor household’s access to housing, the government has provided subsidies to lower production costs and make housing units more affordable to low-income groups. However, mechanisms should be implemented to ensure that the intended targets are the ones who receive it. This issue reviews the beneficiaries of subsidies, its transfer mechanisms and its budgetary implications. This hopes to eliminate the mismatch between what the government should provide and the estimated housing targets.housing finance, housing subsidy, subsidy
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