40,495 research outputs found
Off-equilibrium corrections to energy and conserved charge densities in the relativistic fluid in heavy-ion collisions
Dissipative processes in relativistic fluids are known to be important in the
analyses of the hot QCD matter created in high-energy heavy-ion collisions. In
this work, I consider dissipative corrections to energy and conserved charge
densities, which are conventionally assumed to be vanishing but could be
finite. Causal dissipative hydrodynamics is formulated in the presence of those
dissipative currents. The relation between hydrodynamic stability and transport
coefficients is discussed. I then study their phenomenological consequences on
the observables of heavy-ion collisions in numerical simulations. It is shown
that particle spectra and elliptic flow can be visibly modified.Comment: 10 pages, 5 figures; title changed, references added, conclusions
unchange
Leading interactions in the - compound
The present study shows that the electronic structure of the
- family of compounds () is based on
weakly interacting two-leg ladders, in contrast with the zig-zag chain model
one could expect from their crystal structure. Spin dimer analysis, based on
extended H\"{u}ckel tight-binding calculations, was performed to determine the
structure of the dominant transfer and magnetic interactions in the room
temperature - phase. Two different two-legs ladders,
associated with different charge/spin orders are proposed to describe these
one-dimensional -type systems. The antiferromagnetic ladders are packed
in an 'IPN' geometry and coupled to each other through weak antiferromagnetic
interactions. This arrangement of the dominant interactions explains the
otherwise surprising similarities of the optical conductivity and Raman spectra
for the one-dimensional -type phases and the two-dimensional
-type ones such as the well-known - system
Acute Liver Failure Secondary to Hemophagocytic Lymphohistiocytosis during Pregnancy.
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of excessive immune activation that mimics and occurs with other systemic diseases. A 35-year-old female presented with signs of viral illness at 13 weeks of pregnancy and progressed to acute liver failure (ALF). We discuss the diagnosis of HLH and Kikuchi-Fujimoto (KF) lymphadenitis in the context of pregnancy and ALF. HLH may respond to comorbid disease-specific therapy, and more toxic treatment can be avoided
Phosphofructokinase 1 Glycosylation Regulates Cell Growth and Metabolism
Cancer cells must satisfy the metabolic demands of rapid cell growth within a continually changing microenvironment. We demonstrated that the dynamic posttranslational modification of proteins by O-linked β-N-acetylglucosamine (O-GlcNAcylation) is a key metabolic regulator of glucose metabolism. O-GlcNAcylation was induced at serine 529 of phosphofructokinase 1 (PFK1) in response to hypoxia. Glycosylation inhibited PFK1 activity and redirected glucose flux through the pentose phosphate pathway, thereby conferring a selective growth advantage on cancer cells. Blocking glycosylation of PFK1 at serine 529 reduced cancer cell proliferation in vitro and impaired tumor formation in vivo. These studies reveal a previously uncharacterized mechanism for the regulation of metabolic pathways in cancer and a possible target for therapeutic intervention
Cavallo's Multiplier for in situ Generation of High Voltage
A classic electrostatic induction machine, Cavallo's multiplier, is suggested
for in situ production of very high voltage in cryogenic environments. The
device is suitable for generating a large electrostatic field under conditions
of very small load current. Operation of the Cavallo multiplier is analyzed,
with quantitative description in terms of mutual capacitances between
electrodes in the system. A demonstration apparatus was constructed, and
measured voltages are compared to predictions based on measured capacitances in
the system. The simplicity of the Cavallo multiplier makes it amenable to
electrostatic analysis using finite element software, and electrode shapes can
be optimized to take advantage of a high dielectric strength medium such as
liquid helium. A design study is presented for a Cavallo multiplier in a
large-scale, cryogenic experiment to measure the neutron electric dipole
moment.Comment: 9 pages, 10 figure
Decision aids can support cancer clinical trials decisions: Results of a randomized trial
BACKGROUND. Cancer patients often do not make informed decisions regarding clinical trial participation. This study evaluated whether a web-based decision aid (DA) could support trial decisions compared with our cancer center’s website. METHODS. Adults diagnosed with cancer in the past 6 months who had not previously participated in a cancer clinical trial were eligible. Participants were randomized to view the DA or our cancer center’s website (enhanced usual care [UC]). Controlling for whether participants had heard of cancer clinical trials and educational attainment, multivariable linear regression examined group on knowledge, self-efficacy for finding trial information, decisional conflict (values clarity and uncertainty), intent to participate, decision readiness, and trial perceptions. RESULTS. Two hundred patients (86%) consented between May 2014 and April 2015. One hundred were randomized to each group. Surveys were completed by 87 in the DA group and 90 in the UC group. DA group participants reported clearer values regarding trial participation than UC group participants reported (least squares [LS] mean = 15.8 vs. 32, p < .0001) and less uncertainty (LS mean = 24.3 vs. 36.4, p = .025). The DA group had higher objective knowledge than the UC group’s (LS mean = 69.8 vs. 55.8, p < .0001). There were no differences between groups in intent to participate. CONCLUSIONS. Improvements on key decision outcomes including knowledge, self-efficacy, certainty about choice, and values clarity among participants who viewed the DA suggest web-based DAs can support informed decisions about trial participation among cancer patients facing this preference-sensitive choice. Although better informing patients before trial participation could improve retention, more work is needed to examine DA impact on enrollment and retention. IMPLICATIONS FOR PRACTICE: This paper describes evidence regarding a decision tool to support patients’ decisions about trial participation. By improving knowledge, helping patients clarify preferences for participation, and facilitating conversations about trials, decision aids could lead to decisions about participation that better match patients’ preferences, promoting patient-centered care and the ethical conduct of clinical research
Atomic interferometer measurements of Berry's and Aharonov-Anandan's phases for isolated spins S > 1/2 non-linearly coupled to external fields
The aim of the present paper is to propose experiments for observing the
significant features of Berry's phases for S>1, generated by spin-Hamiltonians
endowed with two couplings, a magnetic dipole and an electric quadrupole one
with external B and E fields, as theoretically studied in our previous work.
The fields are assumed orthogonal, this mild restriction leading to geometric
and algebraic simplifications. Alkali atoms appear as good candidates for
interferometric measurements but there are challenges to be overcome. The only
practical way to generate a suitable E-field is to use the ac Stark effect
which induces an instability of the dressed atom. Besides atom loss, this might
invalidate Berry's phase derivation but this latter problem can be solved by an
appropriate detuning. The former puts an upper limit to the cycle duration,
which is bounded below by the adiabatic condition. By relying upon our previous
analysis of the non-adiabatic corrections, we have been able to reach a
compromise for the Rb hf level F=2, m=0 state, which is our candidate
for an interferometric measurement of the exotic Berry's phase generated by a
rotation of the E-field around the fixed B-field. By a numerical simulation we
have shown that the non-adiabatic corrections can be kept below the 0.1% level.
As an alternative candidate, we discuss the chromium ground state J=S=3, where
the instability problem is easily solved. We make a proposal to extend the
measurement of Aharonov-Anandan's phase beyond S=1/2 to the Rb hf level
F=m=1, by constructing, with the help of light-shifts, a Hamiltonian able to
perform a parallel transport along a closed circuit upon the density matrix
space, without any adiabatic constraint. In Appendix A, Berry's phase
difference for S=3/2 and 1/2, m=1/2 states is used to perform an entanglement
of 3 Qbits.Comment: 23 pages, 6 figures, modifications in the introduction, two
paragraphs adde
Exploration of finite dimensional Kac algebras and lattices of intermediate subfactors of irreducible inclusions
We study the four infinite families KA(n), KB(n), KD(n), KQ(n) of finite
dimensional Hopf (in fact Kac) algebras constructed respectively by A. Masuoka
and L. Vainerman: isomorphisms, automorphism groups, self-duality, lattices of
coideal subalgebras. We reduce the study to KD(n) by proving that the others
are isomorphic to KD(n), its dual, or an index 2 subalgebra of KD(2n). We
derive many examples of lattices of intermediate subfactors of the inclusions
of depth 2 associated to those Kac algebras, as well as the corresponding
principal graphs, which is the original motivation.
Along the way, we extend some general results on the Galois correspondence
for depth 2 inclusions, and develop some tools and algorithms for the study of
twisted group algebras and their lattices of coideal subalgebras. This research
was driven by heavy computer exploration, whose tools and methodology we
further describe.Comment: v1: 84 pages, 13 figures, submitted. v2: 94 pages, 15 figures, added
connections with Masuoka's families KA and KB, description of K3 in KD(n),
lattices for KD(8) and KD(15). v3: 93 pages, 15 figures, proven lattice for
KD(6), misc improvements, accepted for publication in Journal of Algebra and
Its Application
Housing Subsidies: A Closer Look at the Issues
To improve poor household’s access to housing, the government has provided subsidies to lower production costs and make housing units more affordable to low-income groups. However, mechanisms should be implemented to ensure that the intended targets are the ones who receive it. This issue reviews the beneficiaries of subsidies, its transfer mechanisms and its budgetary implications. This hopes to eliminate the mismatch between what the government should provide and the estimated housing targets.housing finance, housing subsidy, subsidy
- …
