Spectrum-generating Symmetries for BPS Solitons

We show that there exist nonlinearly realised duality symmetries that are independent of the standard supergravity global symmetries, and which provide active spectrum-generating symmetries for the fundamental BPS solitons. The additional ingredient, in any spacetime dimension, is a single scaling transformation that allows one to map between BPS solitons with different masses. Without the inclusion of this additional transformation, which is a symmetry of the classical equations of motion, but not the action, it is not possible to find a spectrum-generating symmetry. The necessity of including this scaling transformation highlights the vulnerability of duality multiplets to quantum anomalies. We argue that fundamental BPS solitons may be immune to this threat.Comment: References added. Latex, 29 page

Microlensing of Sub-parsec Massive Binary Black Holes in Lensed QSOs: Light Curves and Size-Wavelength Relation

Sub-parsec binary massive black holes (BBHs) are long anticipated to exist in many QSOs but remain observationally elusive. In this paper, we propose a novel method to probe sub-parsec BBHs through microlensing of lensed QSOs. If a QSO hosts a sub-parsec BBH in its center, it is expected that the BBH is surrounded by a circum-binary disk, each component of the BBH is surrounded by a small accretion disk, and a gap is opened by the secondary component in between the circum-binary disk and the two small disks. Assuming such a BBH structure, we generate mock microlensing light curves for some QSO systems that host BBHs with typical physical parameters. We show that microlensing light curves of a BBH QSO system at the infrared-optical-UV bands can be significantly different from those of corresponding QSO system with a single massive black hole (MBH), mainly because of the existence of the gap and the rotation of the BBH (and its associated small disks) around the center of mass. We estimate the half-light radii of the emission region at different wavelengths from mock light curves and find that the obtained half-light radius vs. wavelength relations of BBH QSO systems can be much flatter than those of single MBH QSO systems at a wavelength range determined by the BBH parameters, such as the total mass, mass ratio, separation, accretion rates, etc. The difference is primarily due to the existence of the gap. Such unique features on the light curves and half-light radius-wavelength relations of BBH QSO systems can be used to select and probe sub-parsec BBHs in a large number of lensed QSOs to be discovered by current and future surveys, including the Panoramic Survey Telescope and Rapid Response System (Pan-STARRS), the Large Synoptic Survey telescope (LSST) and Euclid.Comment: 18 pages, 17 figures, accepted for publication in the Astrophysical Journa

Antrodia cinnamomea reduces obesity and modulates the gut microbiota in high-fat diet-fed mice.

BackgroundObesity is associated with gut microbiota dysbiosis, disrupted intestinal barrier and chronic inflammation. Given the high and increasing prevalence of obesity worldwide, anti-obesity treatments that are safe, effective and widely available would be beneficial. We examined whether the medicinal mushroom Antrodia cinnamomea may reduce obesity in mice fed with a high-fat diet (HFD).MethodsMale C57BL/6J mice were fed a HFD for 8 weeks to induce obesity and chronic inflammation. The mice were treated with a water extract of A. cinnamomea (WEAC), and body weight, fat accumulation, inflammation markers, insulin sensitivity and the gut microbiota were monitored.ResultsAfter 8 weeks, the mean body weight of HFD-fed mice was 39.8±1.2 g compared with 35.8±1.3 g for the HFD+1% WEAC group, corresponding to a reduction of 4 g or 10% of body weight (P<0.0001). WEAC supplementation reduced fat accumulation and serum triglycerides in a statistically significant manner in HFD-fed mice. WEAC also reversed the effects of HFD on inflammation markers (interleukin-1β, interleukin-6, tumor necrosis factor-α), insulin resistance and adipokine production (leptin and adiponectin). Notably, WEAC increased the expression of intestinal tight junctions (zonula occludens-1 and occludin) and antimicrobial proteins (Reg3g and lysozyme C) in the small intestine, leading to reduced blood endotoxemia. Finally, WEAC modulated the composition of the gut microbiota, reducing the Firmicutes/Bacteroidetes ratio and increasing the level of Akkermansia muciniphila and other bacterial species associated with anti-inflammatory properties.ConclusionsSupplementation with A. cinnamomea produces anti-obesogenic, anti-inflammatory and antidiabetic effects in HFD-fed mice by maintaining intestinal integrity and modulating the gut microbiota

The Low-level Spectrum of the W3W_3 String

We investigate the spectrum of physical states in the $W_3$ string theory, up to level 2 for a multi-scalar string, and up to level 4 for the two-scalar string. The (open) $W_3$ string has a photon as its only massless state. By using screening charges to study the null physical states in the two-scalar $W_3$ string, we are able to learn about the gauge symmetries of the states in the multi-scalar $W_3$ string.Comment: 31 pages, Plain Tex, CTP TAMU-70/92, Goteborg ITP 92-43, Imperial/TP/91-92/22, KCL-TH-92-

Electron multiplier development /phase 1/

Fabrication of aluminum oxide thin film window for capillary type photomultiplier tube