Software architectures and Open Source Software: Where can research leverage the most?

Software architectures have been playing a central role in software engineering research for some years now. They are considered of pivotal importance in the success of complex software systems development. However, with the emergence of Open Source Software (OSS) development, a new opportunity for studying architectural issues arises. In this paper, we introduce accepted notions of software architectures (Section 2), discuss some of the known issues in OSS (Section 3), resulting in a set of aspects we consider to be relevant for future research (Section 4)

Interdisciplinary insights on Open Source

The term “open source” is widely applied to describe some software development methodologies. This paper does not provide a judgment on the open source approach, but exposes the fact that simply stating that a project is open source does not provide a precise description of the approach used to support the project. By taking a multidisciplinary point of view, we propose a collection of characteristics that are common, as well as some that vary among open source projects. The set of open source characteristics we found can be used as a tick-list both for analysing and for setting up open source projects. Our tick-list also provides a starting point for understanding the many meanings of the term open source

Nonlinear optical magnetometry with accessible in situ optical squeezing

We demonstrate compact and accessible squeezed-light magnetometry using four-wave mixing in a single hot rubidium vapor cell. The strong intrinsic coherence of the four wave mixing process results in nonlinear magneto-optical rotation (NMOR) on each mode of a two mode relative-intensity squeezed state. This framework enables 4.7 dB of quantum noise reduction while the opposing polarization rotation signals of the probe and conjugate fields add to increase the total signal to noise ratio

Quantum-Enhanced Plasmonic Sensing

Quantum resources can enhance the sensitivity of a device beyond the classical shot noise limit and, as a result, revolutionize the field of metrology through the development of quantum-enhanced sensors. In particular, plasmonic sensors, which are widely used in biological and chemical sensing applications, offer a unique opportunity to bring such an enhancement to real-life devices. Here, we use bright entangled twin beams to enhance the sensitivity of a plasmonic sensor used to measure local changes in refractive index. We demonstrate a 56% quantum enhancement in the sensitivity of state-of-the-art plasmonic sensor with measured sensitivities on the order of $10^{-10}$RIU$/\sqrt{\textrm{Hz}}$, nearly 5 orders of magnitude better than previous proof-of-principle implementations of quantum-enhanced plasmonic sensors. These results promise significant enhancements in ultratrace label free plasmonic sensing and will find their way into areas ranging from biomedical applications to chemical detection

Extraordinary optical transmission of multimode quantum correlations via localized surface plasmons

We demonstrate the coherent transduction of quantum noise reduction, or squeezed light, by Ag localized surface plasmons (LSPs). Squeezed light, generated through four-wave-mixing in Rb vapor, is coupled to a Ag nanohole array designed to exhibit LSP-mediated extraordinary-optical transmission (EOT) spectrally coincident with the squeezed light source at 795 nm. We demonstrate that quantum noise reduction as a function of transmission is found to match closely with linear attenuation models, thus demonstrating that the photon-LSP-photon transduction process is coherent near the LSP resonance

The parasitic worm-derived immunomodulator, ES-62 and its drug-like small molecule analogues exhibit therapeutic potential in a model of chronic asthma

Chronic asthma is associated with persistent lung inflammation and long-term remodelling of the airways that have proved refractory to conventional treatments such as steroids, despite their efficacy in controlling acute airway contraction and bronchial inflammation. As its recent dramatic increase in industrialised countries has not been mirrored in developing regions, it has been suggested that helminth infection may protect humans against developing asthma. Consistent with this, ES-62, an immunomodulator secreted by the parasitic worm Acanthocheilonema viteae, can prevent pathology associated with chronic asthma (cellular infiltration of the lungs, particularly neutrophils and mast cells, mucus hyper-production and airway thickening) in an experimental mouse model. Importantly, ES-62 can act even after airway remodelling has been established, arresting pathogenesis and ameliorating the inflammatory flares resulting from repeated exposure to allergen that are a debilitating feature of severe chronic asthma. Moreover, two chemical analogues of ES-62, 11a and 12b mimic its therapeutic actions in restoring levels of regulatory B cells and suppressing neutrophil and mast cell responses. These studies therefore provide a platform for developing ES-62-based drugs, with compounds 11a and 12b representing the first step in the development of a novel class of drugs to combat the hitherto intractable disorder of chronic asthma

Perturbative nonequilibrium dynamics of phase transitions in an expanding universe

A complete set of Feynman rules is derived, which permits a perturbative description of the nonequilibrium dynamics of a symmetry-breaking phase transition in $\lambda\phi^4$ theory in an expanding universe. In contrast to a naive expansion in powers of the coupling constant, this approximation scheme provides for (a) a description of the nonequilibrium state in terms of its own finite-width quasiparticle excitations, thus correctly incorporating dissipative effects in low-order calculations, and (b) the emergence from a symmetric initial state of a final state exhibiting the properties of spontaneous symmetry breaking, while maintaining the constraint $\equiv 0$. Earlier work on dissipative perturbation theory and spontaneous symmetry breaking in Minkowski spacetime is reviewed. The central problem addressed is the construction of a perturbative approximation scheme which treats the initial symmetric state in terms of the field $\phi$, while the state that emerges at later times is treated in terms of a field $\zeta$, linearly related to $\phi^2$. The connection between early and late times involves an infinite sequence of composite propagators. Explicit one-loop calculations are given of the gap equations that determine quasiparticle masses and of the equation of motion for $$ and the renormalization of these equations is described. The perturbation series needed to describe the symmetric and broken-symmetry states are not equivalent, and this leads to ambiguities intrinsic to any perturbative approach. These ambiguities are discussed in detail and a systematic procedure for matching the two approximations is described.Comment: 22 pages, using RevTeX. 6 figures. Submitted to Physical Review

Nonequilibrium perturbation theory for complex scalar fields

Real-time perturbation theory is formulated for complex scalar fields away from thermal equilibrium in such a way that dissipative effects arising from the absorptive parts of loop diagrams are approximately resummed into the unperturbed propagators. Low order calculations of physical quantities then involve quasiparticle occupation numbers which evolve with the changing state of the field system, in contrast to standard perturbation theory, where these occupation numbers are frozen at their initial values. The evolution equation of the occupation numbers can be cast approximately in the form of a Boltzmann equation. Particular attention is given to the effects of a non-zero chemical potential, and it is found that the thermal masses and decay widths of quasiparticle modes are different for particles and antiparticles.Comment: 15 pages using RevTeX; 2 figures in 1 Postscript file; Submitted to Phys. Rev.

Large-N transition temperature for superconducting films in a magnetic field

We consider the $N$-component Ginzburg-Landau model in the large $N$ limit, the system being embedded in an external constant magnetic field and confined between two parallel planes a distance $L$ apart from one another. On physical grounds, this corresponds to a material in the form of a film in the presence of an external magnetic field. Using techniques from dimensional and $zeta$-function regularization, modified by the external field and the confinement conditions, we investigate the behavior of the system as a function of the film thickness $L$. This behavior suggests the existence of a minimal critical thickness below which superconductivity is suppressed.Comment: Revtex, two column, 4 pages, 2 figure