Impact of IFN lambda 3/4 single nucleotide polymorphisms on the cytomegalovirus reactivation in autologous stem cell transplant patients

Cytomegalovirus (CMV) infection represents one of the main cause mortality after Stem Cell Transplantation. Recently, a protective effect of the T allele of rs12979860 IL28B Single Nucleotide Polymorphisms (SNPs) against CMV infection in the allogenic stem cell transplantation was suggested. We investigate whether the rs12979860 IL28B SNP and the relative rs368234815 (IFNλ4) genotype may affect the incidence of active CMV infection in Autologous stem cell transplantation (Auto-SCT) setting. The study included 99 patients who underwent to Auto-SCT. IL28 and IFNΔ4 SNPs were correlated with CMV reactivation along with other clinical and treatment parameters. CMV reactivation by CMV DNAemia was evaluated once a week until day 100 from Auto-SCT. CMV reactivation was documented in 50% (TT-ΔG/ΔG), 35% (CC-TT/TT) and 29.2% (CT-TT/ΔG) of the patients respectively. No differences in CMV copies number were recorded at reactivation between different IL28/IFNλ4 genotypes. The analysis of patients older than 60 years showed a significantly higher incidence of active CMV infection in the TT-ΔG/ΔG (83%) population with respect to CC-TT/TT (21%) and CT-TT/ΔG (40%) patients. Our data suggest a negative role of TT-ΔG/ΔG genotype in the CMV reactivation in Auto-SCT. The exposure to rituximab and the pre-infusion presence of anti CMV IgG also significantly influenced CMV reactivation

University teaching and potential of geographic information systems in Project Cycle Management cycle in international development for cooperation

This paper presents the first results of a pilot project tackling the nexus among Gis and spatial analysis, international cooperation and higher education. This experience shows that it seems appropriate to use a dialectical approach between theory and practice to develop knowledge, competences and operational skills to be used potentially in all project cycle management phases. The teaching pilot project held at the University of Bologna within the undergraduate curriculum in Development and International Cooperation (Svic) has led to develop a syllabus and a methodological framework for a full laboratory-course allowing students to be professionally ready to apply Gis in practice

Clinical comparative study of thermal mud and water therapy versus magnetotherapy in patients with gonarthrosis

At the Terme di Santa Cesarea (Italy) two samples of patients with gonarthrosis (N = 32 each) were treated for 12 consecutive days respectively with thermal mud and water therapy or magnetotherapy. Efficacy of treatment was assessed utilizing the VAS, the Lequesne index and the self-administered AIMS2 questionnaire. Both treatments showed beneficial effects on measured parameters (P<0.05), but follow-up to 90 days demonstrated a superior comparative long-term efficacy of crenotherapy (P<0.05)

[Post-traumatic arthritis in a patient with Jadassohn's anetoderma].

We describe the emergence of arthritis following a physical trauma, in a young man with clinical and histopathologic features of primary anetoderma (Jadassohn type) of 13 years' duration. Diagnosis of post-traumatic arthritis in a young patient with genetic predisposition was assumed. Indeed septic arthritis and other possible cause of arthritis were ruled out

Un caso di perforazione gastrica: sarà iatrogena...??

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