Modelo de negocio y estrategia editorial: el caso del wsj.com

La investigación sobre modelos de negocios en la industria de la comunicación se ha caracterizado por un elevado grado de experimentación y la ausencia de respuestas unívocas al problema de la rentabilidad de los contenidos digitales. En este escenario, The Wall Street Journal suele ser mencionado como un referente del modelo de suscripción. Este artículo demuestra empíricamente que el modelo del diario económico más prestigioso del mundo ofrece un modelo híbrido en el que los contenidos gratuitos representan el 73% del total publicado en la portada del wsj.com y analiza cuáles son las características comunes que suelen compartir aquellos contenidos de pago frente a las compartidas por los contenidos gratuitos

Design and initial testing of a high speed 45 kW switched reluctance drive for aerospace application

This paper presents innovative research towards the development of a 45 kW high speed switched reluctance drive as an alternative starter-generator for future aero-engines. To perform such a function the machine had to be designed with a very wide constant power-speed range. During engine-start/motoring mode, a peak torque demand of 54 Nm at 8 krpm was met, whilst in generating mode, 19.2-32 krpm, the machine was designed to deliver a constant power of 45 kW. The key enabling feature of the design lies in the novel rotor structure developed so as to allow for such a wide speed range. The results presented, are those measured during the initial testing phase and validate the system design and performance in the low-speed region with the machine operated in starting-mode. The measured machine power density is at 9.8 kW/ltr, whilst the global system efficiency is at 82%

Self-tuning resonant control of a 7-leg back-to-back converter for interfacing variable speed generators to 4-wire loads

This paper considers the control of a 7-leg back-to-back Voltage Source Inverter (VSI) arrangement feeding a 4-wire load from a 3-phase Permanent Magnet Synchronous Generator (PMSG) operating at variable speed. The PMSG is controlled using a sensorless Model Reference Adaptive System (MRAS) to obtain the rotor position angle. The 7-leg converter is regulated using Resonant Controllers (RCs) at the load side and self-tuning resonant controllers at the generator side. The control system is augmented by a feed-forward compensation algorithm which improves the dynamic performance during transients. Experimental results, obtained from a prototype, are presented and discussed

An integrated converter and machine control system for MMC-based high power drives

The Modular Multilevel Converter (MMC) is a promising topology for high power drive applications. However, large voltage fluctuations are produced in the floating capacitors when the machine is operating with high stator currents at low rotational speed. To compensate these oscillations, relatively large mitigation currents are required to keep the capacitor voltages within an acceptable range. In this paper, a new integrated control scheme is discussed to regulate the voltage fluctuations. The strategy is based on closed-loop vector-control of the voltage fluctuations, maintaining them inside a pre-defined threshold. The proposed control system is also augmented using flux weakening operation of the machine at low rotational speeds. An experimental prototype composed of eighteen power cells, feeding a vector-controlled induction machine in the whole speed range, is used to validate the effectiveness and feasibility of the proposed control strategies

On interconnecting and orchestrating components in disaggregated data centers:The dReDBox project vision

Computing systems servers-low-or high-end ones have been traditionally designed and built using a main-board and its hardware components as a 'hard' monolithic building block; this formed the base unit on which the system hardware and software stack design build upon. This hard deployment and management border on compute, memory, network and storage resources is either fixed or quite limited in expandability during design time and in practice remains so throughout machine lifetime as subsystem upgrades are seldomely employed. The impact of this rigidity has well known ramifications in terms of lower system resource utilization, costly upgrade cycles and degraded energy proportionality. In the dReDBox project we take on the challenge of breaking the server boundaries through materialization of the concept of disaggregation. The basic idea of the dReDBox architecture is to use a core of high-speed, low-latency opto-electronic fabric that will bring physically distant components more closely in terms of latency and bandwidth. We envision a powerful software-defined control plane that will match the flexibility of the system to the resource needs of the applications (or VMs) running in the system. Together the hardware, interconnect, and software architectures will enable the creation of a modular, vertically-integrated system that will form a datacenter-in-a-box

Collaborative Gaze Channelling for Improved Cooperation During Robotic Assisted Surgery

The use of multiple robots for performing complex tasks is becoming a common practice for many robot applications. When different operators are involved, effective cooperation with anticipated manoeuvres is important for seamless, synergistic control of all the end-effectors. In this paper, the concept of Collaborative Gaze Channelling (CGC) is presented for improved control of surgical robots for a shared task. Through eye tracking, the fixations of each operator are monitored and presented in a shared surgical workspace. CGC permits remote or physically separated collaborators to share their intention by visualising the eye gaze of their counterparts, and thus recovers, to a certain extent, the information of mutual intent that we rely upon in a vis-à-vis working setting. In this study, the efficiency of surgical manipulation with and without CGC for controlling a pair of bimanual surgical robots is evaluated by analysing the level of coordination of two independent operators. Fitts' law is used to compare the quality of movement with or without CGC. A total of 40 subjects have been recruited for this study and the results show that the proposed CGC framework exhibits significant improvement (p<0.05) on all the motion indices used for quality assessment. This study demonstrates that visual guidance is an implicit yet effective way of communication during collaborative tasks for robotic surgery. Detailed experimental validation results demonstrate the potential clinical value of the proposed CGC framework. © 2012 Biomedical Engineering Society.link_to_subscribed_fulltex

There's no place like OM:Vesicular sorting and secretion of the peptidylarginine deiminase of Porphyromonas gingivalis

The oral pathogen Porphyromonas gingivalis is one of the major periodontal agents and it has been recently hailed as a potential cause of the autoimmune disease rheumatoid arthritis. In particular, the peptidylarginine deiminase enzyme of P. gingivalis (PPAD) has been implicated in the citrullination of certain host proteins and the subsequent appearance of antibodies against citrullinated proteins, which might play a role in the etiology of rheumatoid arthritis. The aim of this study was to investigate the extracellular localization of PPAD in a large panel of clinical P. gingivalis isolates. Here we show that all isolates produced PPAD. In most cases PPAD was abundantly present in secreted outer membrane vesicles (OMVs) that are massively produced by P. gingivalis, and to minor extent in a soluble secreted state. Interestingly, a small subset of clinical isolates showed drastically reduced levels of the OMV-bound PPAD and secreted most of this enzyme in the soluble state. The latter phenotype is strictly associated with a lysine residue at position 373 in PPAD, implicating the more common glutamine residue at this position in PPAD association with OMVs. Further, one isolate displayed severely restricted vesiculation. Together, our findings show for the first time that neither the major association of PPAD with vesicles, nor P. gingivalis vesiculation per se, are needed for P. gingivalis interactions with the human host

Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer

Background Apalutamide, a competitive inhibitor of the androgen receptor, is under development for the treatment of prostate cancer. We evaluated the efficacy of apalutamide in men with nonmetastatic castration-resistant prostate cancer who were at high risk for the development of metastasis. Methods We conducted a double-blind, placebo-controlled, phase 3 trial involving men with nonmetastatic castration-resistant prostate cancer and a prostate-specific antigen doubling time of 10 months or less. Patients were randomly assigned, in a 2:1 ratio, to receive apalutamide (240 mg per day) or placebo. All the patients continued to receive androgen-deprivation therapy. The primary end point was metastasis-free survival, which was defined as the time from randomization to the first detection of distant metastasis on imaging or death. Results A total of 1207 men underwent randomization (806 to the apalutamide group and 401 to the placebo group). In the planned primary analysis, which was performed after 378 events had occurred, median metastasis-free survival was 40.5 months in the apalutamide group as compared with 16.2 months in the placebo group (hazard ratio for metastasis or death, 0.28; 95% confidence interval [CI], 0.23 to 0.35;

Emerging panorama of functional near-infrared spectroscopy in Latin America

Neurophotonics Associate Editors Edgar Guevara and Rickson C. Mesquita, along with Felipe Orihuela-Espina, share their perceptions of the evolution of functional near-infrared spectroscopy in Latin America based on a retrospective literature review and the narratives of three other scientists from the region.</p

Visual gaze patterns reveal surgeons' ability to identify risk of bile duct injury during laparoscopic cholecystectomy

BACKGROUND: Bile duct injury is a serious surgical complication of laparoscopic cholecystectomy. The aim of this study was to identify distinct visual gaze patterns associated with the prompt detection of bile duct injury risk during laparoscopic cholecystectomy. METHODS: Twenty-nine participants viewed a laparoscopic cholecystectomy that led to a serious bile duct injury ('BDI video') and an uneventful procedure ('control video') and reported when an error was perceived that could result in bile duct injury. Outcome parameters include fixation sequences on anatomical structures and eye tracking metrics. Surgeons were stratified into two groups based on performance and compared. RESULTS: The 'early detector' group displayed reduced common bile duct dwell time in the first half of the BDI video, as well as increased cystic duct dwell time and Calot's triangle glances count during Calot's triangle dissection in the control video. Machine learning based classification of fixation sequences demonstrated clear separability between early and late detector groups. CONCLUSION: There are discernible differences in gaze patterns associated with early recognition of impending bile duct injury. The results could be transitioned into real time and used as an intraoperative early warning system and in an educational setting to improve surgical safety and performance