Ligadura de la rama izquierda de la arteria pulmonar por hemoptisis grave

Presented at session 8th September 1943Presentado en sesión de 8 de setiembre de 194

Reemplazos valvulares aórticos y mitrales: tres años de experiencia

The experience of the Department of Cardiac Surgery of the Hospital de Clínicas of Montevideo, fromjul'y 1976 to september 1979 with 44 aortic and 34 mitral replacements, is reported.Se presenta la experiencia del Departamento de Cirugía Cardíaca del Hospital de Clínicasde Montevideo, desd,e julio de 1976 a setiembre de 1979, con 44 reemplazos aórtioos y 34 mitrales

Tratamiento quirúrgico de las cardíacas valvulares afecciones múltiples

The Heart Surgery Department of the Hospital de Cl'inicas (University Medical School Hdspital) of Montevideo, presents its experience between 1976 and 1979, with 14 patients who underwent polivalvular surgery.Se presenta la experiencia del Departamento de Cirugía Cardíaca del Hos,pital de Clínicas de l\'lontevideo, defde 1976 a 1979, con 14 pacientessometidos a procedimientos polivalvulares

El tratamiento quirúrgico de los aneurismas de aorta ascendente asociados a valvulopatía aórtica

The authors present the experience achieved at the Heart Surgery Department of the "Clínicas Hospital" with patients with aneurysm of the ascending aorta and aortic insufficiency.A patient was surgically explored and died suddenly while awaiting his reoperation.A patient who underwent valvular replacement and aneurusmoraffia, died in the postoperative for the strong deterioration of his myocardial function.A patient was operated on replacing his aortic valve and the ascending aorta in its supracoronary portian, protecting him with cardiac paralysis; the near and distant evolution was good.It is currently considered that these patients are to be surgically treated in our enviroment. The surgical technique will depend upon the degree of involvement of the aortic wall in each particular case.The valvular prostheses will be mechanical; since a high rate of dysfunction has been observed with the use of some biological valves in our enviroment. A periodical control with aortography is recoended for an early recognition of the postoperative local complications.Se presenta la experiencia del Departamento de Cirugía Cardíaca del Hospital de Clínicas con pacientes portadores de aneurisma de aorta ascendente de insuficiencia aórtica.Un paciente fue explorado quirúrgicamente y falleció en forma brusca mientras esperaba su reoperación.Un paciente fue sometido a reemplazo valvular y aneurismorrafia; falleció en el postoperatorio por deterioro marcado de la función miocárdica. Un paciente fue operado reemplazándose la válvula aórtica y el aneurisma de la aorta ascendente en su sector supracoronario, protegiendo con cardioplejia: la evolución inmediata y alejada fue buena.Se considera que éstos pacientes son de tratamiento quirúrgico en la actualidad en nuestro medio.La técnica quirúrgica dependerá del compromiso de la pared aórtica en cada caso las prótesis valvulares serán mecánicas, dado el alto índice de disfunción que se han detectado con algunas válvulas biológicas en nuestro medio.Se recomienda el control periódico con aortografía, para detectar precozmente complicaciones locales postoperatorias

Real-Time, Real World Learning—Capitalising on Mobile Technology

This chapter explores the adoption of Web 2.0 technologies to promote active learning by students and to both mediate and enhance classroom instruction. Web 2.0 refers to open source, web-enabled applications (apps) that are driven by user-manipulated and user-generated content (Kassens-Noor, 2012). These apps are often rich in user participation, have dynamic content, and harness the collective intelligence of users (Chen, Hwang, & Wang, 2012). As such, these processes create “active, context based, personalised learning experiences” (Kaldoudi, Konstantinidis, & Bamidis, 2010, p. 130) that prioritise learning ahead of teaching. By putting the learner at the centre of the education process educators can provide environments that enhance employability prospects and spark a passion for learning that, hopefully, lasts a lifetime. As such, we critique an active learning approach that makes use of technology such as mobile applications (apps), Twitter, and augmented reality to enhance students’ real world learning. Dunlap and Lowenthal (2009) argue that social media can facilitate active learning as they recreate informal, free-flowing communications that allow students and academics to connect on a more emotional level. Furthermore, their use upskills students in the technical complexities of the digital world and also the specialised discourses that are associated with online participation, suitable for real world learning and working (Fig. 16.1). Three case studies explore the benefits of Web 2.0 processes. The first details the use of Twitter chats to connect students, academics, and industry professionals via online synchronous discussions that offer a number of benefits such as encouraging concise writing from students and maintaining on-going relationships between staff, students, and industry contacts. The second details a location-based mobile app that delivers content to students when they enter a defined geographical boundary linked to an area of a sports precinct. Finally, we explore the use of augmented reality apps to enhance teaching in Human Geography and Urban Studies

Misguided Transcriptional Elongation Causes Mixed Lineage Leukemia

Investigation of the activity of a family of fusion proteins that cause aggressive leukemia suggests transcriptional elongation as a new mechanism for oncogenic transformation

New Insights into the Control of HIV-1 Transcription: When Tat Meets the 7SK snRNP and Super Elongation Complex (SEC)

Recent studies aimed at elucidating the mechanism controlling HIV-1 transcription have led to the identification and characterization of two multi-subunit complexes that both contain P-TEFb, a human transcription elongation factor and co-factor for activation of HIV-1 gene expression by the viral Tat protein. The first complex, termed the 7SK snRNP, acts as a reservoir where active P-TEFb can be withdrawn by Tat to stimulate HIV-1 transcription. The second complex, termed the super elongation complex (SEC), represents the form of P-TEFb delivered by Tat to the paused RNA polymerase II at the viral long terminal repeat during Tat transactivation. Besides P-TEFb, SEC also contains other elongation factors/co-activators, and they cooperatively stimulate HIV-1 transcription. Recent data also indicate SEC as a target for the mixed lineage leukemia (MLL) protein to promote the expression of MLL target genes and leukemogenesis. Given their roles in HIV-1/AIDS and cancer, further characterization of 7SK snRNP and SEC will help develop strategies to suppress aberrant transcriptional elongation caused by uncontrolled P-TEFb activation. As both complexes are also important for normal cellular gene expression, studying their structures and functions will elucidate the mechanisms that control metazoan transcriptional elongation in general