Interface-induced d-wave pairing

We discuss a scenario for interface-induced superconductivity involving pairing by dipolar excitations proximate to a two-dimensional electron system controlled by a transverse electric field. If the interface consists of transition metal oxide materials, the repulsive on-site Coulomb interaction is typically strong and a superconducting state is formed via exchange of non-local dipolar excitations in the d-wave channel. Perspectives to enhance the superconducting transition temperature are discussed.Comment: 4 pages, 3 figure

Calculation of the kinematics of hypoid gears towards developing a method for an equivalent crossed helical gear pair selection for use in tribological experimental evaluations

To experimentally verify power loss and friction for hypoid gears, measurements in a closed power-loop test rig are necessary. However, these are costly and mechanically complex, since they require additional spur gear reducers in the loop. ISO directives document the use of crossed helical gear pairs as virtual gears for hypoids to calculate the sliding velocity since, the flank geometry at the mean point can be precisely represented. The use of such pairs can be a cost effective and simpler alternative for testing purposes. However, the validity of this analogy regarding contact mechanics and tribology for the full mesh cycle has not been investigated hitherto. In the current study a new method for calculating the sliding and rolling speed along the full path of contact of a hypoid gear pair is presented. Cutter kinematics are considered, for the accurate definition of the contact bodies. Using TCA, the load distribution on the tooth under quasi-static conditions and the sliding velocity are calculated for comparison purposes. By applying a selection algorithm, a single experimental crossed helical gear pair is chosen aiming to simulate the contact conditions of hypoid gears. Two test scenarios are studied using EHL film thickness equations and friction models for evaluating the power loss. The contact is an elongated ellipse with varying directions of the sliding and sum velocities, which are considered in the model. The kinematic equivalence shows good agreement while the tribological equivalence is achievable using a reduced input torque

A Longitudinal Perspective on Sustainability and Innovation Governmentality:The Case of the Olympic Games as a Mega-Event

The purpose of this research is to analyze how governance is related to sustainability and innovation in mega-events over time by looking at the Olympic Games as a case study. Three main contributions are made to management research and practice. First, Foucauldian governmentality is built upon and enriched with a longitudinal perspective by following the evolution of Visibility, Techne, Episteme, and Identity analytics of governmentality. Second, an innovative methodology based on interviews, a systematic documentary review, and software-assisted thematic auto-coding for a theory-led structured analysis is applied. Third, the theoretical and empirical contribution of this study on the longitudinal aspects of governmentality over different parties and outlets of information could be used to guide practical and strategic decisions for managers and policy makers. In addition to its scholarly importance, this work is needed because mega-events can have a sustainable long-term impact, balancing legacy and innovative change

Structural characterization of cationic lipid–tRNA complexes

Despite considerable interest and investigations on cationic lipid–DNA complexes, reports on lipid–RNA interaction are very limited. In contrast to lipid–DNA complexes where lipid binding induces partial B to A and B to C conformational changes, lipid–tRNA complexation preserves tRNA folded state. This study is the first attempt to investigate the binding of cationic lipid with transfer RNA and the effect of lipid complexation on tRNA aggregation and condensation. We examine the interaction of tRNA with cholesterol (Chol), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), dioctadecyldimethylammoniumbromide (DDAB) and dioleoylphosphatidylethanolamine (DOPE), at physiological condition, using constant tRNA concentration and various lipid contents. FTIR, UV-visible, CD spectroscopic methods and atomic force microscopy (AFM) were used to analyze lipid binding site, the binding constant and the effects of lipid interaction on tRNA stability, conformation and condensation. Structural analysis showed lipid–tRNA interactions with G–C and A–U base pairs as well as the backbone phosphate group with overall binding constants of KChol = 5.94 (± 0.8) × 104 M–1, KDDAB = 8.33 (± 0.90) × 105 M–1, KDOTAP = 1.05 (± 0.30) × 105 M–1 and KDOPE = 2.75 (± 0.50) × 104 M–1. The order of stability of lipid–tRNA complexation is DDAB > DOTAP > Chol > DOPE. Hydrophobic interactions between lipid aliphatic tails and tRNA were observed. RNA remains in A-family structure, while biopolymer aggregation and condensation occurred at high lipid concentrations

Structural characterization of cationic lipid–tRNA complexes

Despite considerable interest and investigations on cationic lipid–DNA complexes, reports on lipid–RNA interaction are very limited. In contrast to lipid–DNA complexes where lipid binding induces partial B to A and B to C conformational changes, lipid–tRNA complexation preserves tRNA folded state. This study is the first attempt to investigate the binding of cationic lipid with transfer RNA and the effect of lipid complexation on tRNA aggregation and condensation. We examine the interaction of tRNA with cholesterol (Chol), 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP), dioctadecyldimethylammoniumbromide (DDAB) and dioleoylphosphatidylethanolamine (DOPE), at physiological condition, using constant tRNA concentration and various lipid contents. FTIR, UV-visible, CD spectroscopic methods and atomic force microscopy (AFM) were used to analyze lipid binding site, the binding constant and the effects of lipid interaction on tRNA stability, conformation and condensation. Structural analysis showed lipid–tRNA interactions with G–C and A–U base pairs as well as the backbone phosphate group with overall binding constants of KChol = 5.94 (± 0.8) × 104 M–1, KDDAB = 8.33 (± 0.90) × 105 M–1, KDOTAP = 1.05 (± 0.30) × 105 M–1 and KDOPE = 2.75 (± 0.50) × 104 M–1. The order of stability of lipid–tRNA complexation is DDAB > DOTAP > Chol > DOPE. Hydrophobic interactions between lipid aliphatic tails and tRNA were observed. RNA remains in A-family structure, while biopolymer aggregation and condensation occurred at high lipid concentrations

Developing novel fibres for endoscopic imaging and sensing

We are developing the next generation of optical fibres for endoscopic imaging and sensing. Our imaging fibre bundle is fabricated from OM1 PCVD graded index preforms made for the telecommunications market. Whilst having a lower numerical aperture, the performance of the imaging fibre is shown to be comparable to the current state-of-the-art commercial microendoscopy fibres. In addition, we are developing negative-curvature optical fibres, which exhibit ultra-low silica Raman background. Measuring Raman spectra through an optical fibre is usually complicated by the high intrinsic Raman scatter of the fibre material. Common solutions such as the use of multiple fibres and distal optics are complex and bulky. The single hollow core negative curvature fibre is used for Raman and surface-enhanced Raman spectroscopy sensing with no distal optics while showing a 1000x background reduction compared to conventional fibres.</p

Ultra-low background Raman sensing using a negative-curvature fibre and no distal optics

Measuring Raman spectra through an optical fibre is usually complicated by the high intrinsic Raman scatter of the fibre material. Common solutions such as the use of multiple fibres and distal optics are complex and bulky. We demonstrate the use of single novel hollow-core negative-curvature fibres (NCFs) for Raman and surface-enhanced Raman spectroscopy (SERS) sensing using no distal optics. The background Raman emission from the silica in the NCF was at least 1000× smaller than in a conventional solid fibre, while maintaining the same collection efficiency. We transmitted pump light from a 785-nm laser through the NCF, and we collected back the weak Raman spectra of different distal samples, demonstrating the fibre probe can be used for measurements of weak Raman and SERS signals that would otherwise overlap spectrally with the silica background. The lack of distal optics and consequent small probe diameter (&lt;0.25 mm) enable applications that were not previously possible.</p

Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: Similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"

Caveolin-1 (-/-) null stromal cells are a novel genetic model for cancer-associated fibroblasts and myofibroblasts. Here, we used an unbiased informatics analysis of transcriptional gene profiling to show that Cav-1 (-/-) bone-marrow derived stromal cells bear a striking resemblance to the activated tumor stroma of human breast cancers. More specifically, the transcriptional profiles of Cav-1 (-/-) stromal cells were most closely related to the primary tumor stroma of breast cancer patients that had undergone lymph-node (LN) metastasis. This is consistent with previous morphological data demonstrating that a loss of stromal Cav-1 protein (by immuno-histochemical staining in the fibroblast compartment) is significantly associated with increased LN-metastasis. We also provide evidence that the tumor stroma of human breast cancers shows a transcriptional shift towards oxidative stress, DNA damage/repair, inflammation, hypoxia, and aerobic glycolysis, consistent with the "Reverse Warburg Effect". Finally, the tumor stroma of "metastasis-prone" breast cancer patients was most closely related to the transcriptional profiles derived from the brains of patients with Alzheimer's disease. This suggests that certain fundamental biological processes are common to both an activated tumor stroma and neuro-degenerative stress. These processes may include oxidative stress, NO over-production (peroxynitrite formation), inflammation, hypoxia, and mitochondrial dysfunction, which are thought to occur in Alzheimer's disease pathology. Thus, a loss of Cav-1 expression in cancer-associated myofibroblasts may be a protein biomarker for oxidative stress, aerobic glycolysis, and inflammation, driving the "Reverse Warburg Effect" in the tumor micro-environment and cancer cell metastasis