Surface characterization

The biocompatibility of commercially pure titanium and its alloys is closely related to their surface properties, with both the composition of the protecting oxide film and the surface topography playing an important role. Surfaces of commercially pure titanium and of the two alloys Ti-6Al-7Nb and Ti-6Al-4V (wt %) have been investigated following three different pretreatments: polishing, nitric acid passivation and pickling in nitric acid-hydrogen fluoride. Nitric acid treatment is found to substantially reduce the concentration of surface contaminants present after polishing. The natural 4-6 nm thick oxide layer on commercially pure titanium is composed of titanium oxide in different oxidation states (TiO2, Ti2O3 and TiO), while for the alloys, aluminium and niobium or vanadium are additionally present in oxidized form (Al2O3, Nb2O5 or V-oxides). The concentrations of the alloying elements at the surface are shown to be strongly dependent on the pretreatment process. While pickling increases the surface roughness of both commercially pure titanium and the alloys, different mechanisms appear to be involved. In the case of commercially pure titanium, the dissolution rate depends on grain orientation, whereas in the case of the two alloys, selective α-phase dissolution and enrichment of the β-phase appears to occur. © 1999 Kluwer Academic Publisher

Allogeneic Stem Cells Alter Gene Expression and Improve Healing of Distal Limb Wounds in Horses.

Distal extremity wounds are a significant clinical problem in horses and humans and may benefit from mesenchymal stem cell (MSC) therapy. This study evaluated the effects of direct wound treatment with allogeneic stem cells, in terms of gross, histologic, and transcriptional features of healing. Three full-thickness cutaneous wounds were created on each distal forelimb in six healthy horses, for a total of six wounds per horse. Umbilical cord-blood derived equine MSCs were applied to each wound 1 day after wound creation, in one of four forms: (a) normoxic- or (b) hypoxic-preconditioned cells injected into wound margins, or (c) normoxic- or (d) hypoxic-preconditioned cells embedded in an autologous fibrin gel and applied topically to the wound bed. Controls were one blank (saline) injected wound and one blank fibrin gel-treated wound per horse. Data were collected weekly for 6 weeks and included wound surface area, thermography, gene expression, and histologic scoring. Results indicated that MSC treatment by either delivery method was safe and improved histologic outcomes and wound area. Hypoxic-preconditioning did not offer an advantage. MSC treatment by injection resulted in statistically significant increases in transforming growth factor beta and cyclooxygenase-2 expression at week 1. Histologically, significantly more MSC-treated wounds were categorized as pro-healing than pro-inflammatory. Wound area was significantly affected by treatment: MSC-injected wounds were consistently smaller than gel-treated or control wounds. In conclusion, MSC therapy shows promise for distal extremity wounds in horses, particularly when applied by direct injection into the wound margin. Stem Cells Translational Medicine 2018;7:98-108

The implant material, Ti6Al7Nb: surface microstructure, composition and properties

The excellent biocompatibility of titanium and its alloys is intimately related with the properties of the surface in contact with the biological environment, and therefore it is closely connected with the stable, passivating oxide layer that forms on its surface. In the present paper, the oxide layer on the alloy Ti6Al7Nb has been characterized using X-ray photoelectron spectroscopy, scanning Auger microscopy and pH-dependent lateral force microscopy. The alloying elements Al and Nb are incorporated in the oxide layer and detected in their most stable oxidized form, as Al2O3 and Nb2O5. Their distribution in the oxide reflects the underlying α-β microstructure, with enrichment of Al in the α- and of Nb in the β-phase (determined by electron microprobe). Friction measurements (lateral force microscopy) indicate slightly different, pH-dependent, lateral forces above the α- and β-phase structures that point to small local variations in surface charges. © 1999 Kluwer Academic Publisher

Numerical simulation of scavenging processes in explosive volcanic eruption clouds

The scavenging of gases and particles in an explosive volcanic eruption plume has been studied by numerical simulations with the plume model ATHAM (Active Tracer High Resolution Atrnospheric Model). We identified relevant factors that determine the fraction of volcanic material eventually being injected into the stratosphere. An extended version of the microphysics has been formulated: predicting both the specific rnass content and the number concentration it de- scribes the interaction of hydrometeors and voicanic ash in the plume, which leads to particle growth and efficient sedimentation. In addition, we developed a mod- ule for the calculation of volcanic gas scavenging by liquid and solid hydrometeors in the plume. This study reveals the dominant role of hydrometeors in controlling many pro- cesses in the plume. The coating of volcanic ash with liquid water or ice results in highly efficient growth of particles, which strongly enhances the fallout velocity of ash. Precipitation of aggregates results in efficient gas-particle separation, which increases the injection of volcanic gases into the stratosphere. In addition, it strongly influences the stream pattern, which in turn influences the microphysics in the plume by lowering the supersaturation in the ascent zone. By far the highest portion of condensed water freezes to ice in the eruption colurnn. The fast plurne rise to regions, which are too cold for even supercooled liquid water to exist causes rnost particles to occur as ice-ash aggregates. We examined the scavenging of the most important volcanic gases, HCl, SO2 and H2S, by liquid and solid hydrometeors and by aggregates in the plume. The scavenging efficiency is determined by the amount of condensed water or ice. HC1 is almost completely removed from the gas phase by dissolution in liquid water occurring in the lower central plurne. These ash-containing drops quickly freeze to graupel aggregates that precipitate efficiently, thus also removing HCl from higher altitudes. On the other hand, a large extent of SO2 and HzS stays at high levels in the umbrella region. The sulphur species are only slightly soluble in liquid water, hence, they are not removed by liquid water drops. However, they are scavenged by frozen hydrorneteors via direct gas incorporation during diffusional growth of ice. This causes a reduction by - 25% of the potential input of an inert volcanic gas, indicating the great relevance of gas trapping in ice. Low relative humidity in the troposphere in our simulations caused precipitation to reevaporate before it could reach the ground. As a consequence, no evidence of hydrometeor-ash interaction or gas scavenging could be found in the fallout of the eruption simulated here, although these processes occurred to a significant degree in upper parts of the plume

Context Dependence, MOPs,WHIMs and procedures Recanati and Kaplan on Cognitive Aspects in Semantics

After presenting Kripke’s criticism to Frege’s ideas on context dependence of thoughts, I present two recent attempts of considering cognitive aspects of context dependent expressions inside a truth conditional pragmatics or semantics: Recanati’s non-descriptive modes of presentation (MOPs) and Kaplan’s ways of having in mind (WHIMs). After analysing the two attempts and verifying which answers they should give to the problem discussed by Kripke, I suggest a possible interpretation of these attempts: to insert a procedural or algorithmic level in semantic representations of indexicals. That a function may be computed by different procedures might suggest new possibilities of integrating contextual cognitive aspects in model theoretic semanti

Self-organized Te redistribution during driven reconnection processes in high-temperature plasmas

Two-dimensional (2D) images of electron temperature fluctuations with high temporal and spatial resolution were employed to study the sawtooth oscillation in Toroidal EXperiment for Technology Oriented Research [S. S. Abdallaev et al., Nucl. Fusion 43, 299 (2003)] tokamak plasmas. The new findings are: (1) 2D images revealed that the reconnection is localized and permitted the determination of the physical dimensions of the reconnection zone in the poloidal and toroidal planes. (2) The combination of a pressure bulge due to finite pressure effects or a kink instability accompanied with a sharp pressure point leads to an "X-point" reconnection process. (3) Reconnection can take place anywhere along the q similar to 1 rational magnetic surface (both high- and low-field sides). (4) Heat flow from the core to the outside of the inversion radius during the reconnection time is through the finite opening on the poloidal and toroidal planes and the flow is highly collective. These new findings are compared with the characteristics of various theoretical models and experimental results for the study of the sawtooth oscillation in tokamak plasmas. (c) 2006 American Institute of Physics

Modeling of biomass smoke injection into the lower stratosphere by a large forest fire (Part I): reference simulation

Wildland fires in boreal regions have the potential to initiate deep convection, so-called pyro-convection, due to their release of sensible heat. Under favorable atmospheric conditions, large fires can result in pyro-convection that transports the emissions into the upper troposphere and the lower stratosphere. Here, we present three-dimensional model simulations of the injection of fire emissions into the lower stratosphere by pyro-convection. These model simulations are constrained and evaluated with observations obtained from the Chisholm fire in Alberta, Canada, in 2001. The active tracer high resolution atmospheric model (ATHAM) is initialized with observations obtained by radiosonde. Information on the fire forcing is obtained from ground-based observations of the mass and moisture of the burned fuel. Based on radar observations, the pyro-convection reached an altitude of about 13 km, well above the tropopause, which was located at about 11.2 km. The model simulation yields a similarly strong convection with an overshoot of the convection above the tropopause. The main outflow from the pyro-convection occurs at about 10.6 km, but a significant fraction (about 8%) of the emitted mass of the smoke aerosol is transported above the tropopause. In contrast to regular convection, the region with maximum updraft velocity in the pyro-convection is located close to the surface above the fire. This results in high updraft velocities >10 m s^−1 at cloud base. The temperature anomaly in the plume decreases rapidly with height from values above 50 K at the fire to about 5 K at about 3000 m above the fire. While the sensible heat released from the fire is responsible for the initiation of convection in the model, the release of latent heat from condensation and freezing dominates the overall energy budget. Emissions of water vapor from the fire do not significantly contribute to the energy budget of the convection