Galaxy Formation by Galactic Magnetic Fields

Galaxies exhibit a sequence of various morphological types, i.e., the Hubble sequence, and they are basically composed of spheroidal components (elliptical galaxies and bulges in spiral galaxies) and disks. It is known that spheroidal components are found only in relatively massive galaxies with M=10^{10-12} M_sun, and all stellar populations in them are very old, but there is no clear explanation for these facts. Here we present a speculative scenario for the origin of the Hubble sequence, in which magnetic fields ubiquitously seen in galaxies have played a crucial role. We first start from a strange observational fact that magnetic field strengths observed in spiral galaxies sharply concentrate at a few microgauss, for a wide range of galaxy luminosity and types. We then argue that this fact and the observed correlation between star formation activity and magnetic field strength in spiral galaxies suggest that spheroidal galaxies have formed by starbursts induced by strong magnetic fields. Then we show that this idea naturally leads to the formation of spheroidal systems only in massive and high-redshift objects in hierarchically clustering universe, giving a simple explanation for various observations.Comment: 7 pages including 2 figures. Accepted by ApJ Letter

Establishing the entatic state in folding metallated Pseudomonas aeruginosa azurin

Understanding how the folding of proteins establishes their functional characteristics at the molecular level challenges both theorists and experimentalists. The simplest test beds for confronting this issue are provided by electron transfer proteins. The environment provided by the folded protein to the cofactor tunes the metal's electron transport capabilities as envisioned in the entatic hypothesis. To see how the entatic state is achieved one must study how the folding landscape affects and in turn is affected by the metal. Here, we develop a coarse-grained functional to explicitly model how the coordination of the metal (which results in a so-called entatic or rack-induced state) modifies the folding of the metallated Pseudomonas aeruginosa azurin. Our free-energy functional-based approach directly yields the proper nonlinear extra-thermodynamic free energy relationships for the kinetics of folding the wild type and several point-mutated variants of the metallated protein. The results agree quite well with corresponding laboratory experiments. Moreover, our modified free-energy functional provides a sufficient level of detail to explicitly model how the geometric entatic state of the metal modifies the dynamic folding nucleus of azurin

Coherent acoustic vibration of metal nanoshells

Using time-resolved pump-probe spectroscopy we have performed the first investigation of the vibrational modes of gold nanoshells. The fundamental isotropic mode launched by a femtosecond pump pulse manifests itself in a pronounced time-domain modulation of the differential transmission probed at the frequency of nanoshell surface plasmon resonance. The modulation amplitude is significantly stronger and the period is longer than in a gold nanoparticle of the same overall size, in agreement with theoretical calculations. This distinct acoustical signature of nanoshells provides a new and efficient method for identifying these versatile nanostructures and for studying their mechanical and structural properties.Comment: 5 pages, 3 figure

Large-scale magnetic fields in cosmology

Despite the widespread presence of magnetic fields, their origin, evolution and role are still not well understood. Primordial magnetism sounds appealing but is not problem free. The magnetic implications for the large-scale structure of the universe still remain an open issue. This paper outlines the advantages and shortcomings of early-time magnetogenesis and the typical role of B-fields in linear structure-formation scenarios.Comment: Invited Talk (36th EPS Conference on Plasma Physics, 2009

The energy spectrum observed by the AGASA experiment and the spatial distribution of the sources of ultra-high energy cosmic rays

Seven and a half years of continuous monitoring of giant air showers triggered by ultra high-energy cosmic rays have been recently summarized by the AGASA collaboration. The resulting energy spectrum indicates clearly that the cosmic ray spectrum extends well beyond the Greisen-Zatsepin-Kuzmin (GZK) cut-off at $\sim 5 \times 10^{19}$ eV. Furthermore, despite the small number statistics involved, some structure in the spectrum may be emerging. Using numerical simulations, it is demonstrated in the present work that these features are consistent with a spatial distribution of sources that follows the distribution of luminous matter in the local Universe. Therefore, from this point of view, there is no need for a second high-energy component of cosmic rays dominating the spectrum beyond the GZK cut-off.Comment: 14 pages, 4 figures, Astrophys. J. Letters (submitted

The critical velocity effect as a cause for the H\alpha emission from the Magellanic stream

Observations show significant H\alpha-emissions in the Galactic halo near the edges of cold gas clouds of the Magellanic Stream. The source for the ionization of the cold gas is still a widely open question. In our paper we discuss the critical velocity effect as a possible explanation for the observed H\alpha-emission. The critical velocity effect can yield a fast ionization of cold gas if this neutral gas passes through a magnetized plasma under suitable conditions. We show that for parameters that are typical for the Magellanic Stream the critical velocity effect has to be considered as a possible ionization source of high relevance.Comment: 9 pages, 2 figures. accepted, to appear in The Astrophysical Journa

Acid-Labile Traceless Click Linker for Protein Transduction

Intracellular delivery of active proteins presents an interesting approach in research and therapy. We created a protein transduction shuttle based on a new traceless click linker that combines the advantages of click reactions with implementation of reversible pH-sensitive bonds. The azidomethyl-methylmaleic anhydride (AzMMMan) linker was found compatible with different click chemistries, demonstrated in bioreversible protein modification with dyes, polyethylene glycol, or a transduction carrier. Linkages were stable at physiological pH but reversible at the mild acidic pH of endosomes or lysosomes. We show that pH-reversible attachment of a defined endosome-destabilizing three-arm oligo(ethane amino)amide carrier generates an effective shuttle for protein delivery. The cargo protein nlsEGFP, when coupled via the traceless AzMMMan linker, experiences efficient cellular uptake and endosomal escape into the cytosol, followed by import into the nucleus. In contrast, irreversible linkage to the same shuttle hampers nuclear delivery of nlsEGFP which after uptake remains trapped in the cytosol. Successful intracellular delivery of bioactive ß-galactosidase as a model enzyme was also demonstrated using the pH-controlled shuttle system

Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery

Aims: To compare MRI and MRA with Doppler-echocardiography (DE) in native and postoperative aortic coarctation, define the best MR protocol for its evaluation, compare MR with surgical findings in native coarctation. Materials and methods: 136 MR studies were performed in 121 patients divided in two groups: Group I, 55 preoperative; group II, 81 postoperative. In group I, all had DE and surgery was performed in 35 cases. In group II, DE was available for comparison in 71 cases. MR study comprised: spin-echo, cine, velocity-encoded cine (VEC) sequences and 3D contrast-enhanced MRA. Results: In group I, diagnosis of coarctation was made by DE in 33 cases and suspicion of coarctation and/or aortic arch hypoplasia in 18 cases. Aortic arch was not well demonstrated in 3 cases and DE missed one case. There was a close correlation between VEC MRI and Doppler gradient estimates across the coarctation, between MRI aortic arch diameters and surgery but a poor correlation in isthmic measurements. In group II, DE detected a normal isthmic region in 31 out of 35 cases. Postoperative anomalies (recoarctation, aortic arch hypoplasia, kinking, pseudoaneurysm) were not demonstrated with DE in 50% of cases. Conclusions: MRI is superior to DE for pre and post-treatment evaluation of aortic coarctation. An optimal MR protocol is proposed. Internal measurement of the narrowing does not correspond to the external aspect of the surgical narrowin