Manajemen Kinerja Organisasi Dinas Koperasi dan USAha Mikro Kecil dan Menengah (UMKM) Kota Pekanbaru

Department of Cooperatives and Micro, Small and Medium Enterprises (SMEs) in Pekanbaru City is an implementation services unit in the field of Cooperatives and SMEs in Pekanbaru. One of the problems that occur are many SMEs and the informal sectors are not bankable yet due to the lack of managerial and financial capabilities. Then the lack of technology knowledge, marketing skills and the limitation of small enterprises to fulfill the products / services according to market demand, as well as limitations and lack of human resources. And the lack of protection for ideas and products produced by SMEs and the informal sectors as well as government policy or supporting regulations which they do not optimally support the development of SMEs. The current number of SMEs in Pekanbaru City around 15.291.000 spread over 12 districts in Pekanbaru. Supposedly with the large number of SMEs in Pekanbaru, SMEs can develop properly, the Departement provides special training for SMEs entrepreneur, as well as the good performance management of Department of Cooperatives and SMEs in Pekanbaru City to SMEs entrepreneur for the advancement of SMEs in Pekanbaru so that SMEs products can be known widely. But in fact, the products of SMEs have not been able to compete widely. Based on this, the author wanted to conduct a qualitative descriptive study on Organizational Performance Management of Department of Cooperatives and Micro, Small and Medium Enterprises (SMEs) in Pekanbaru City and the factors that influence it.Theoretical concept used by the author is the theoretical performance of Agus Dwiyanto: Productivity, Quality, Service, Responsiveness, Responsibility, Accountability. And factors that affecting organizational performance management. This study used a qualitative research with descriptive assessment. The collecting data of this study are by interview, observation and documentation.The results of this study indicate that the Organizational Performance Management of Department of Cooperatives and Micro, Small and Medium Enterprises (SMEs) in Pekanbaru City is not optimal yet. Then there are factors that affect the performance management encountered in the field two factors that affecting performance management are internal and external factor. The internal factor are quantity and quality of human resources, employee\u27s motivation. While external factors are the society and SMEs products

Autotrophic and heterotrophic acquisition of carbon and nitrogen by a mixotrophic chrysophyte established through stable isotope analysis

Collectively, phagotrophic algae (mixotrophs) form a functional continuum of nutritional modes between autotrophy and heterotrophy, but the specific physiological benefits of mixotrophic nutrition differ among taxa. Ochromonas spp. are ubiquitous chrysophytes that exhibit high nutritional flexibility, although most species generally fall towards the heterotrophic end of the mixotrophy spectrum. We assessed the sources of carbon and nitrogen in Ochromonas sp. strain BG-1 growing mixotrophically via short-term stable isotope probing. An axenic culture was grown in the presence of either heat-killed bacteria enriched with ^(15)N and ^(13)C, or unlabeled heat-killed bacteria and labeled inorganic substrates (^(13)C-bicarbonate and ^(15)N-ammonium). The alga exhibited high growth rates (up to 2 divisions per day) only until heat-killed bacteria were depleted. NanoSIMS and bulk IRMS isotope analyses revealed that Ochromonas obtained 84–99% of its carbon and 88–95% of its nitrogen from consumed bacteria. The chrysophyte assimilated inorganic ^(13)C-carbon and ^(15)N-nitrogen when bacterial abundances were very low, but autotrophic (photosynthetic) activity was insufficient to support net population growth of the alga. Our use of nanoSIMS represents its first application towards the study of a mixotrophic alga, enabling a better understanding and quantitative assessment of carbon and nutrient acquisition by this species

Pan-cancer analysis of whole genomes

Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale(1-3). Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4-5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter(4); identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation(5,6); analyses timings and patterns of tumour evolution(7); describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity(8,9); and evaluates a range of more-specialized features of cancer genomes(8,10-18).Peer reviewe

Temperature-dependent dynamics of polyalkylthiophene conjugated polymers: a combined neutron scattering and simulation study

International audienc

Follow-up of blood donors positive for hepatitis B surface antigen

From 1973 to 1977 in Amsterdam the incidence of hepatitis B surface antigen (HBsAg) in blood donations from new donors was 0.224 and from known donors 0.034%. 65 donors, previously found positive for HBsAg, were re-examined. Persistence of HBsAg in new donors (28 of 31) occurred significantly (p less than 0.0005) more often than in known donors (15 of 34). All carriers were classified into HBeAg (21%) or anti-HBe (79%) by a sensitive Elisa technique. Abnormal liver function tests (LFTs) were observed in 30% of the carriers and were significantly (p less than 0.005) more often found in HBeAg than in anti-HBe-positive carriers. When the LFTs remained abnormal, in almost all (8 of 9) carriers moderate to severe histological liver disease was diagnose