Time-Dependent Warping, Fluxes, and NCYM

We describe the supergravity solutions dual to D6-branes with both time-dependent and time-independent B-fields. These backgrounds generalize the Taub-NUT metric in two key ways: they have asymmetric warp factors and background fluxes. In the time-dependent case, the warping takes a novel form. Kaluza-Klein reduction in these backgrounds is unusual, and we explore some of the new features. In particular, we describe how a localized gauge-field emerges with an analogue of the open string metric and coupling. We also describe a gravitational analogue of the Seiberg-Witten map. This provides a framework in supergravity both for studying non-commutative gauge theories, and for constructing novel warped backgrounds.Comment: 32 pages, LaTeX, references adde

Estimating the global conservation status of more than 15,000 Amazonian tree species

Estimates of extinction risk for Amazonian plant and animal species are rare and not often incorporated into land-use policy and conservation planning. We overlay spatial distribution models with historical and projected deforestation to show that at least 36% and up to 57% of all Amazonian tree species are likely to qualify as globally threatened under International Union for Conservation of Nature (IUCN) Red List criteria. If confirmed, these results would increase the number of threatened plant species on Earth by 22%. We show that the trends observed in Amazonia apply to trees throughout the tropics, and we predict thatmost of the world’s >40,000 tropical tree species now qualify as globally threatened. A gap analysis suggests that existing Amazonian protected areas and indigenous territories will protect viable populations of most threatened species if these areas suffer no further degradation, highlighting the key roles that protected areas, indigenous peoples, and improved governance can play in preventing large-scale extinctions in the tropics in this century

Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET

The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR

Diversidad de razas caprinas criollas en Argentina

Se estima que el 90% de los casi cinco millones de caprinos en Argentina se pueden asignar a poblaciones locales tradicionalmente llamadas Criollos. Se denomina así a un colectivo indefinido, menospreciado en sus atributos fenotípicos y productivos característicos, originados a partir de selección por diferentes etnias y en general adaptados a ambientes disímiles y hostiles de crianza. Con el objetivo de determinar las características diferenciales de razas locales o biotipos dentro de las Criollas contribuyendo a su valoración como recurso genético, se recuperaron trabajos de caracterización fenotípica realizados desde el año 2000 hasta el 2013. Se construyó una base datos a partir de las originales, con 19 variables cualitativas y cuantitativas de 2170 hembras de 6 poblaciones locales: Criollas de Formosa (FOR), Córdoba (CBA), La Rioja (LRI), San Luis (SLU), Neuquén (NQN) y Colorada Pampeana (LPA). Se analizó en forma descriptiva y multivariada para detectar diferencias y similitudes entre ellas. Los resultados mostraron rasgos compartidos (perfil recto; orejas horizontales) y divergentes (tipo de pelaje, perímetro de la caña). Los conglomerados formados en base al análisis factorial de datos mixtos muestran una clara diferenciación para FOR, LPA y NQN. CBA muestra rasgos de cruzamientos con Anglo Nubian, LRI y SLU se muestran dispersas. Se formaron 4 clústeres con buena definición para FOR, LPA, CBA y NQN. Se concluye que las razas Criolla Formoseña, Neuquina y Colorada Pampeana alcanzan un grado de diferenciación fenotípico significativo. LRI y SLU no muestran clara diferenciación y la CBA evidencia signos de cruzamientos con razas comerciales y riesgo de erosión genética.It is estimated that 90% of the almost five million goats in Argentina are local populations traditionally called Criollo. This designation refers to goats whose phenotypic and productive attributes are neglected. These populations have different origins and were selected by diverse rural communities; however, they share some common characteristics, such as being adapted to harsh environmental conditions and being bred in arid areas. In order to determine the differential traits of local breeds within Criollo and contribute to their assessment as a local genetic resource, phenotypic characterization research carried out in the last decades were recovered. A database was built, with 19 qualitative and quantitative variables of 2170 females from 6 local populations: Criolla de Formosa (FOR), Córdoba (CBA), La Rioja (LRI), San Luis (SLU), Neuquén (NQN) and Colorada Pampeana (LPA). They were analysed descriptively and by multivariate analysis in order to define differences and similarities among them. The results showed shared (straight profile, horizontal ears) and divergent (type of coat, shin circumference) features. The conglomerates formed on the basis of the mixed data factor analysis showed a clear differentiation for FOR, LPA and NQN. CBA showed evidence of crossing with Anglo Nubian, while LRI and SLU were scattered. Four Clusters with good definition were formed for FOR, LPA, CBA and NQN. It is concluded that FOR, NQN and LPA populations have achieved a significant degree of phenotypic differentiation. The LRI and SLU did not show a clear differentiation and the CBA showed signs of crossing with commercial breeds and risk of genetic erosion.Estación Experimental Agropecuaria BarilocheFil: Lanari, María Rosa. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Giovannini, Nicolas. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Bariloche; ArgentinaFil: Maizon, Daniel Omar. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: Deza, Maria C.V. Universidad Nacional de Cordoba. Facultad de Ciencias Agropecuarias; ArgentinaFil: Bedotti, Daniel Osvaldo. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Anguil; ArgentinaFil: de la Rosa-Carbajal, Sebastian Arnoldo. Centro de Validacion Laguna Yema; ArgentinaFil: Vera, Tomas Anibal. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Investigación y Desarrollo Tecnológico para la Agricultura Familiar. Región NOA; ArgentinaFil: Ricarte, Ramon Armando. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; ArgentinaFil: Mezzadra, Carlos Alberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Balcarce; Argentin

Essential oil of Thymus vulgaris: preparation of pharmaceutical mouthwash formulation and in vitro evaluation of the bacterial plaque-inhibiting properties

O objetivo deste estudo foi avaliar in vitro o efeito do óleo essencial de Thymus vulgaris (tomilho) puro ou incorporado em uma formulação farmacêutica de uso oral (enxaguatório bucal), frente ao Streptococcus mutans (ATCC 25175), determinando-se sua concentração inibitoria minima (CIM) e o efeito na formação da placa bacteriana. A CIM obtida para o óleo essencial de tomilho foi de 100 μg/mL (1 %). Procedeu-se o desenvolvimento de enxaguatório bucal com efeito antiplaca contendo o óleo essencial comercial de tomilho. As análises da formação da placa bacteriana (ensaios microbiológicos, análise macroscópica de aderência e análises por MEV) confirmaram a eficácia destas novas formulações de enxaguatórios, sem álcool, contendo óleo essencial de T. vulgaris como agentes antiplaca bacteriana com possível emprego na odontologia preventiva. A caracterização química do óleo essencial bioativo foi realizada por CG-MS, verificando-se a presença de carvacrol, p-cimeno e α-pineno como constituintes majoritáriosThe aim of this study was to evaluate the in vitro effect of the essential oil of Thymus vulgaris (thyme) pure or incorporate in a alcohol-free pharmaceutical mouthwash formulation, against Streptococcus mutans (ATCC 25175), being determined the Minimal Inhibitory Concentration (MIC) and the effect in the bacterial plate formation. The MIC value obtained for the essential oil was 100 μg/mL (1 %). The mouthwash pharmaceutical formulation containing commercial essential oil of T. vulgaris was preparated. Microbiological and macroscopic analysis as well as analyses for MEV confirmed the effectiveness of this new alcohol-free mouthwash formulation containing essential oil of T. vulgaris as agent with plaqueinhibiting properties and possible application in the preventive dentistry. The chemical characterization of the bioactive essential oil was accomplished by CG-MS, being verified the presence of carvacrol, p-cimene and α- pinene as major constituents.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Current Opinions on Optimal Management of Basilar Artery Occlusion: After the BEST of BASICS Survey

Background The best management of basilar artery occlusion (BAO) remains uncertain. The BASICS (Basilar Artery International Cooperation Study) and the BEST (Basilar Artery Occlusion Endovascular Intervention Versus Standard Medical Treatment) trials reported neutral results. We sought to understand physicians’ approaches to BAOs and whether further BAO randomized controlled trials were warranted. Methods We conducted an online international survey from January to March 2022 to stroke neurologists and neurointerventionalists. Survey questions were designed to examine clinical and imaging parameters under which clinicians would offer (or rescind) a patient with BAO to endovascular therapy (EVT) or best medical management versus enrollment into a randomized clinical trial. Results Of >3002 invited participants, 1245 responded (41.4% response rate) from 73 countries, including 54.7% stroke neurologists and 43.6% neurointerventionalists. More than 95% of respondents would offer EVT to patients with BAO, albeit in various clinical circumstances. There were 70.0% of respondents who indicated that the BASICS and BEST trials did not change their practice. Only 22.1% of respondents would perform EVT according to anterior circulation occlusion criteria. The selection of patients for BAO EVT by clinical severity, timing, and imaging modality differed according to geography, specialty, and country income level. Over 80% of respondents agreed that further randomized clinical trials for BAO were warranted. Moreover, 45.6% of respondents indicated they would find it acceptable to enroll all trial‐eligible patients into the medical arm of a BAO trial, whereas 26.3% would not enroll. Conclusion Most stroke physicians continue to believe in the efficacy of EVT in selected patients with BAO in spite of BEST and BASICS. There is no consensus on which selection criteria to use, and few clinicians would use anterior circulation occlusion criteria for BAOs. Further randomized clinical trials for BAO are warranted

Basilar artery occlusion management: An international survey of middle versus high-income countries

Background and Purpose Two early basilar artery occlusion (BAO) randomized controlled trials (RCTs) did not establish the superiority of endovascular thrombectomy (EVT) over medical management. Yet many providers continued to recommend EVT. The goal of the present article is to compare physicians’ diagnostic and management strategies of BAO among middle-income and high-income countries (MICs and HICs, respectively). Methods We conducted an international survey from January to March 2022 regarding management strategies in acute BAO, to examine clinical and imaging parameters influencing clinician management of patients with BAO. We compared responses between physicians from HIC and MIC. Results Among the 1245 respondents from 73 countries, 799 (64.2%) were from HIC, with the remaining 393 (31.6%) from MIC. Most respondents perceived that EVT was superior to medical management for acute BAO, but more so in respondents from HIC (98.0% vs. 94.2%, p < 0.01). MIC respondents were more likely to believe further RCTs were warranted (91.6% vs. 74.0%, p < 0.01) and were more likely to find it acceptable to enroll any patient who met a trial’s criteria in the standard medical treatment arm (58.8% vs. 38.5%, p < 0.01).Conclusions Conclusions In an area where clinical equipoise was called into question despite the lack of RCT evidence, we found that respondents from MIC were more likely to express willingness to enroll patients with BAO in an RCT than their HIC counterparts