Evidence for Paleolake Rawtenstall around Stacksteads, Upper Irwell Valley, Rossendale, U.K.

This paper presents new geomorphological and sedimentological evidence relating to the glaciation of the Upper Rossendale Valley, northwest England. We identify a previously unrecognised esker and associated glaciofluvial deposits within the valley, using high-resolution hillshaded Digital Terrain Models (DTMs) constructed using LiDAR data. A temporary exposure in a subaqueous outwash fan indicates the operation of an efflux jet from a conduit exiting an ice margin in the vicinity of theThrutch (Stacksteads) Gorge. We propose that the gorge was formed primarily by incision due to the drainage of the ice-dammed paleolake Rawtenstall during a previous glacial phase, but later operated as a subglacial meltwater channel after a local readvance of ice during the last Glacial Termination. A similar approach in other areas is likely to improve our detailed understanding of glaciation in the North West

Suppression of HBV by Tenofovir in HBV/HIV coinfected patients : a systematic review and meta-analysis

Background: Hepatitis B coinfection is common in HIV-positive individuals and as antiretroviral therapy has made death due to AIDS less common, hepatitis has become increasingly important. Several drugs are available to treat hepatitis B. The most potent and the one with the lowest risk of resistance appears to be tenofovir (TDF). However there are several questions that remain unanswered regarding the use of TDF, including the proportion of patients that achieves suppression of HBV viral load and over what time, whether suppression is durable and whether prior treatment with other HBV-active drugs such as lamivudine, compromises the efficacy of TDF due to possible selection of resistant HBV strains. Methods: A systematic review and meta-analysis following PRISMA guidelines and using multilevel mixed effects logistic regression, stratified by prior and/or concomitant use of lamivudine and/or emtricitabine. Results: Data was available from 23 studies including 550 HBV/HIV coinfected patients treated with TDF. Follow up was for up to seven years but to ensure sufficient power the data analyses were limited to three years. The overall proportion achieving suppression of HBV replication was 57.4%, 79.0% and 85.6% at one, two and three years, respectively. No effect of prior or concomitant 3TC/FTC was shown. Virological rebound on TDF treatment was rare. Interpretation: TDF suppresses HBV to undetectable levels in the majority of HBV/HIV coinfected patients with the proportion fully suppressed continuing to increase during continuous treatment. Prior treatment with 3TC/FTC does not compromise efficacy of TDF treatment. The use of combination treatment with 3TC/FTC offers no significant benefit over TDF alone

Irish Ice Sheet dynamics during deglaciation of the central Irish Midlands: Evidence of ice streaming and surging from airborne LiDAR

High resolution digital terrain models (DTMs) generated from airborne LiDAR data and supplemented by field evidence are used to map glacial landform assemblages dating from the last glaciation (Midlandian glaciation; OI stages 2-3) in the central Irish Midlands. The DTMs reveal previously unrecognised low-amplitude landforms, including crevasse-squeeze ridges and mega-scale glacial lineations overprinted by conduit fills leading to ice-marginal subaqueous deposits. We interpret this landform assemblage as evidence for surging behaviour during ice recession. The data indicate that two separate phases of accelerated ice flow were followed by ice sheet stagnation during overall deglaciation. The second surge event was followed by a subglacial outburst flood, forming an intricate esker and crevasse-fill network. The data provide the first clear evidence that ice flow direction was eastward along the eastern watershed of the Shannon River basin, at odds with previous models, and raise the possibility that an ice stream existed in this area. Our work demonstrates the potential for airborne LiDAR surveys to produce detailed paleoglaciological reconstructions and to enhance our understanding of complex palaeo ice sheet dynamics

The Insulin-Like Growth Factor System in the Long-Lived Naked Mole-Rat.

Naked mole-rats (Heterocephalus glaber) (NMRs) are the longest living rodents known. They show negligible senescence, and are resistant to cancers and certain damaging effects associated with aging. The insulin-like growth factors (IGFs) have pluripotent actions, influencing growth processes in virtually every system of the body. They are established contributors to the aging process, confirmed by the demonstration that decreased IGF signaling results in life-extending effects in a variety of species. The IGFs are likewise involved in progression of cancers by mediating survival signals in malignant cells. This report presents a full characterization of the IGF system in the NMR: ligands, receptors, IGF binding proteins (IGFBPs), and IGFBP proteases. A particular emphasis was placed on the IGFBP protease, pregnancy-associated plasma protein-A (PAPP-A), shown to be an important lifespan modulator in mice. Comparisons of IGF-related genes in the NMR with human and murine sequences indicated no major differences in essential parts of the IGF system, including PAPP-A. The protease was shown to possess an intact active site despite the report of a contradictory genome sequence. Furthermore, PAPP-A was expressed and translated in NMRs cells and retained IGF-dependent proteolytic activity towards IGFBP-4 and IGF-independent activity towards IGFBP-5. However, experimental data suggest differential regulatory mechanisms for PAPP-A expression in NMRs than those described in humans and mice. This overall description of the IGF system in the NMR represents an initial step towards elucidating the complex molecular mechanisms underlying longevity, and how these animals have evolved to ensure a delayed and healthy aging process

The Faces in Infant-Perspective Scenes Change over the First Year of Life

Mature face perception has its origins in the face experiences of infants. However, little is known about the basic statistics of faces in early visual environments. We used head cameras to capture and analyze over 72,000 infant-perspective scenes from 22 infants aged 1-11 months as they engaged in daily activities. The frequency of faces in these scenes declined markedly with age: for the youngest infants, faces were present 15 minutes in every waking hour but only 5 minutes for the oldest infants. In general, the available faces were well characterized by three properties: (1) they belonged to relatively few individuals; (2) they were close and visually large; and (3) they presented views showing both eyes. These three properties most strongly characterized the face corpora of our youngest infants and constitute environmental constraints on the early development of the visual system

Plant perception of β-aminobutyric acid is mediated by an aspartyl-tRNA synthetase

Specific chemicals can prime the plant immune system for augmented defense. β-aminobutyric acid (BABA) is a priming agent that provides broad-spectrum disease protection. However, BABA also suppresses plant growth when applied in high doses, which has hampered its application as a crop defense activator. Here we describe a mutant of Arabidopsis thaliana that is impaired in BABA-induced disease immunity (ibi1) but is hypersensitive to BABA-induced growth repression. IBI1 encodes an aspartyl-tRNA synthetase. Enantiomer-specific binding of the R enantiomer of BABA to IBI1 primed the protein for noncanonical defense signaling in the cytoplasm after pathogen attack. This priming was associated with aspartic acid accumulation and tRNA-induced phosphorylation of translation initiation factor eIF2α. However, mutation of eIF2α-phosphorylating GCN2 kinase did not affect BABA-induced immunity but relieved BABA-induced growth repression. Hence, BABA-activated IBI1 controls plant immunity and growth via separate pathways. Our results open new opportunities to separate broad-spectrum disease resistance from the associated costs on plant growth

Seasonal controls on deposition of Late Devensian glaciolacustrine sediments, Central ireland: Implications for the construction of a varve chronology for the British-Irish ice sheet

Laminated pro-glacial glaciolacustrine sediments dating from the Late Devensian (22-10,000 bp) from central Ireland were examined using a combination of detailed logging and scanning electron microscope surface texture and fabric analyses. The sediments are rhythmically laminated and consist of coarser, pale silt layers which alternate with darker clay layers containing occasional thin laminae of fine sand and coarse silt. The pale silt layers contain grains with surface textures indicative of a combination of fluvial, glacial and aeolian transport and contain single or multiple normally graded laminae, erosional surfaces and soft sediment deformation structures, indicating deposition from multiple high density underflows, with occasional dumping of wind-blown sediment into the lake. The dark clay layers have sharp upper and lower contacts and an internal fabric consistent with deposition from a combination of flocculation and grain-by-grain deposition. The thin laminae of coarser material have surface textures consistent with subglacial and fluvial transport only and are interpreted as underflows from subglacial discharges. The sediments are interpreted as annually laminated (varved)

Home Telehealth Uptake and Continued Use Among Heart Failure and Chronic Obstructive Pulmonary Disease Patients: a Systematic Review

Background Home telehealth has the potential to benefit heart failure (HF) and chronic obstructive pulmonary disease (COPD) patients, however large-scale deployment is yet to be achieved. Purpose The aim of this review was to assess levels of uptake of home telehealth by patients with HF and COPD and the factors that determine whether patients do or do not accept and continue to use telehealth. Methods This research performs a narrative synthesis of the results from included studies. Results Thirty-seven studies met the inclusion criteria. Studies that reported rates of refusal and/or withdrawal found that almost one third of patients who were offered telehealth refused and one fifth of participants who did accept later abandoned telehealth. Seven barriers to, and nine facilitators of, home telehealth use were identified. Conclusions Research reports need to provide more details regarding telehealth refusal and abandonment, in order to understand the reasons why patients decide not to use telehealth

Buses, cars, bicycles and walkers the influence of the type of human transport on the flight responses of waterbirds

One way to manage disturbance to waterbirds in natural areas where humans require access is to promote the occurrence of stimuli for which birds tolerate closer approaches, and so cause fewer responses. We conducted 730 experimental approaches to 39 species of waterbird, using five stimulus types (single walker, three walkers, bicycle, car and bus) selected to mimic different human management options available for a controlled access, Ramsar-listed wetland. Across species, where differences existed (56% of 25 cases), motor vehicles always evoked shorter flight-initiation distances (FID) than humans on foot. The influence of stimulus type on FID varied across four species for which enough data were available for complete cross-stimulus analysis. All four varied FID in relation to stimuli, differing in 4 to 7 of 10 possible comparisons. Where differences occurred, the effect size was generally modest, suggesting that managing stimulus type (e.g. by requiring people to use vehicles) may have species-specific, modest benefits, at least for the waterbirds we studied. However, different stimulus types have different capacities to reduce the frequency of disturbance (i.e. by carrying more people) and vary in their capacity to travel around important habita