‘Scots and Scabs from North-by-Tweed’:Undesirable Scottish Migrants in Seventeenth- and Early Eighteenth-Century England

While very prominent in the contemporary world, anxiety about the potentially negative impact that immigrants might have on their host communities has deep historical roots. In a British context, such fears were particularly heightened following the regal union of 1603 when large numbers of Scots began settling in England. This article offers a fresh perspective on these issues by exploring the experiences and reception of poor, deviant or otherwise ‘undesirable’ Scottish migrants to England during the seventeenth and eighteenth centuries. Focusing in particular on chapmen, vagrants and criminals, it suggests that, while in general Scots were able to integrate relatively easily into English society, there existed an unwelcome subset surviving by dubious means. Though not usually attracting unduly severe treatment on account of their nationality, these unwelcome migrants had a disproportionate effect on English perceptions of and attitudes towards the broader cohort of Scottish migrants in their midst

Human LPLUNC1 is a secreted product of goblet cells and minor glands of the respiratory and upper aerodigestive tracts

Long PLUNC1 (LPLUNC1, C20orf114) is a member of a family of poorly described proteins (PLUNCS) expressed in the upper respiratory tract and oral cavity, which may function in host defence. Although it is one of the most highly expressed genes in the upper airways and has been identified in sputum and nasal secretions by proteomic studies, localisation of LPLUNC1 protein has not yet been described. We developed affinity purified antibodies and localised the protein in tissues of the human respiratory tract, oro- and nasopharynx. We have complemented these studies with analysis of LPLUNC1 expression in primary human lung cell cultures and used Western blotting to study the protein in cell culture secretions and in BAL. LPLUNC1 is a product of a population of goblet cells in the airway epithelium and nasal passages and is also present in airway submucosal glands and minor glands of the oral and nasal cavities. The protein is not expressed in peripheral lung epithelial cells. LPLUNC1 is present in bronchoalveolar lavage fluid as two glycosylated isoforms and primary airway epithelial cells produce identical proteins as they undergo mucociliary differentiation. Our results suggest that LPLUNC1 is an abundant, secreted product of goblet cells and minor mucosal glands of the respiratory tract and oral cavity and suggest that the protein functions in the complex milieu that protects the mucosal surfaces in these locations

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely

Irish sources for Spenser's View

The first section of the View is widely understood to be influenced by the twelfth-century texts of Gerald of Wales, as transmitted by Richard Stanyhurst in his Plain and Perfect Description of Ireland included in Holinshed (1577). These works describe the Norman intervention in Ireland as a civilizing process. Such an identification of sources is problematic, however, because the ultimate purpose of the View was to discredit Stanyhurst’s argument that Irish-born descendants of the Norman conquerors of Ireland (the so-called “Old English”) should complete that task. This case of problematic sourcing is resolved given that Stanyhurst’s original text reappeared in the 1587 edition of Holinshed’s Chronicle accompanied by some translations from the writings of Gerald of Wales made by John Hooker (an English Protestant antiquarian), and also by Hooker’s own History of Ireland 1546–86, wherein Hooker attributes the disturbed condition of the country to the recalcitrance of Old English lords. This, for Hooker, and also for Spenser, proved that the Irish population of English descent was in greater need of reform than their Gaelic neighbors. Given that this was the novel argument of the View, and given close echoes between Hooker’s description of famine in Munster and similar passages in the View, Hooker’s contribution to the 1587 edition of Holinshed’s Chronicle is arguably the most potent influence on Spenser’s work.peer-reviewed2019-01-3