New results from an extensive aging test on bakelite Resistive Plate Chambers

We present recent results of an extensive aging test, performed at the CERN Gamma Irradiation Facility on two single--gap RPC prototypes, developed for the LHCb Muon System. With a method based on a model describing the behaviour of an RPC under high particle flux conditions, we have periodically measured the electrode resistance R of the two RPC prototypes over three years: we observe a large spontaneous increase of R with time, from the initial value of about 2 MOhm to more than 250 MOhm. A corresponding degradation of the RPC rate capabilities, from more than 3 kHz/cm2 to less than 0.15 kHz/cm2 is also found.Comment: 6 pages, 7 figures, presented at Siena 2002, 8th Topical Seminar on Innovative Particle and Radiation Detectors 21-24 October 2002, Siena, Ital

Gaucher Disease and Myelofibrosis: A Combined Disease or a Misdiagnosis?

Background: Gaucher disease (GD) and primary myelofibrosis (PMF) share similar clinical and laboratory features, such as cytopenia, hepatosplenomegaly, and marrow fibrosis, often resulting in a misdiagnosis. Case Report: We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia. Based on bone marrow (BM) findings and on liver biopsy showing extramedullary hematopoiesis, an initial diagnosis of PMF was formulated. The patient refused stem cell transplantation from an HLA-identical sibling. Low-dose melphalan was given, without any improvement. Two years later, a BM evaluation showed Gaucher cells. Low glucocerebrosidase and high chitotriosidase levels were indicative for GD. Molecular analysis revealed N370S/complex I mutations. Enzyme replacement therapy with imiglucerase was commenced, resulting in clinical and hematological improvements. Due to an unexpected and persistent organomegaly, PMF combined with GD were suspected. JAK2V617F, JAK2 exon 12, MPL, calreticulin, and exon 9 mutations were negative, and BM examination showed no marrow fibrosis. PMF was excluded. Twenty years after starting treatment, the peripheral cell count and liver size were normal, whereas splenomegaly persisted. Conclusion: In order to avoid a misdiagnosis, a diagnostic algorithm for patients with hepatosplenomegaly combined with cytopenia is suggested

Recommendations for primary care physicians to improve HPV vaccination rates during clinical encounters

The availability of the human papillomavirus (HPV) vaccine has positioned primary care physicians to play an active role in ensuring its successful implementation. However, physicians must be aware of common knowledge, attitudes, and belief barriers associated with HPV and the vaccine that are often encountered during clinical visits. This editorial provides primary care physicians an overview of these barriers and realistic recommendations utilizing the "5A's" – Awareness, Assess, Address, Acceptability, and Activate. This mnemonic can help facilitate a physician's systematic approach to increasing HPV vaccination rates during the clinical encounter

Nucleon generalized polarizabilities within a relativistic Constituent Quark Model

Nucleon generalized polarizabilities are investigated within a relativistic framework, defining such quantities through a Lorentz covariant multipole expansion of the amplitude for virtual Compton scattering. The key physical ingredients in the calculation of the nucleon polarizabilities are the Lorentz invariant reduced matrix elements of the electromagnetic transition current, which can be evaluated from off-energy-shell helicity amplitudes. The evolution of the proton paramagnetic polarizability, $\beta_{para}(q)$, as a function of the virtual-photon three-momentum transfer $q,$ is explicitly evaluated within a relativistic constituent quark model by adopting transition form factors obtained in the light-front formalism. The discussion is focussed on the role played by the effects due to the relativistic approach and to the transition form factors, derived within different models.Comment: 14 pages and three figures (included), to appear in Phys. Rev. C (May 1998

Covariant nucleon electromagnetic form factors from the Goldstone-boson-exchange quark model

We present a study of proton and neutron electromagnetic form factors for the recently proposed Goldstone-boson-exchange constituent quark model. Results for charge radii, magnetic moments, and electric as well as magnetic form factors are reported. The calculations are performed in a covariant framework using the point-form approach to relativistic quantum mechanics. All the predictions by the Goldstone-boson-exchange constituent quark model are found in remarkably good agreement with existing experimental data.Comment: LATEX, 10 pages, including 4 ps-figures, slightly modified, one additional referenc

Splitting of the pi - rho spectrum in a renormalized light-cone QCD-inspired model

We show that the splitting between the light pseudo-scalar and vector meson states is due to the strong short-range attraction in the ^1S_0 sector which makes the pion and the kaon light particles. We use a light-cone QCD-inspired model of the mass squared operator with harmonic confinement and a Dirac-delta interaction. We apply a renormalization method to define the model, in which the pseudo-scalar ground state mass fixes the renormalized strength of the Dirac-delta interaction.Comment: 9 pages, 2 figures, revtex, accepted by Phys. Rev. D; Corrected typo

Space-like and time-like pion electromagnetic form factor and Fock state components within the Light-Front dynamics

The simultaneous investigation of the pion electromagnetic form factor in the space- and time-like regions within a light-front model allows one to address the issue of non-valence components of the pion and photon wave functions. Our relativistic approach is based on a microscopic vector meson dominance (VMD) model for the dressed vertex where a photon decays in a quark-antiquark pair, and on a simple parametrization for the emission or absorption of a pion by a quark. The results show an excellent agreement in the space like region up to -10 $(GeV/c)^2$, while in time-like region the model produces reasonable results up to 10 $(GeV/c)^2$.Comment: 74 pages, 11 figures, use revtex

Relativistic Quark Spin Coupling Effects in the Correlations Between Nucleon Electroweak Properties

We investigate the effect of different relativistic spin couplings of constituent quarks on nucleon electroweak properties. Within each quark spin coupling scheme the correlations between static electroweak observables are found to be independent of the particular shape of the momentum part of the nucleon light-front wave function. The neutron charge form factor is very sensitive to different choices of spin coupling schemes once the magnetic moment is fitted to the experimental value. However, it is found rather insensitive to the details of the momentum part of the three-quark wave function model.Comment: 23 pages, 13 figures, requires axodraw.sty 1 figure corrected, 1 refs. added, some changes in tex

A collimation system for ELI-NP Gamma Beam System - design and simulation of performance

The purpose of this study was to evaluate the performance and refine the design of the collimation system for the gamma radiation source (GBS) currently being realised at ELI-NP facility. The gamma beam, produced by inverse Compton scattering, will provide a tunable average energy in the range between 0.2 and 20 MeV, an energy bandwidth 0.5% and a flux of about 108 photons/s. As a result of the inverse Compton interaction, the energy of the emitted radiation is related to the emission angle, it is maximum in the backscattering direction and decreases as the angle increase [1,2]. Therefore, the required energy bandwidth can be obtained only by developing a specific collimation system of the gamma beam, i.e. filtering out the radiation emitted at larger angles. The angular acceptance of the collimation for ELI-NP-GBS must be continuously adjustable in a range from about 700 to 60 μrad, to obtain the required parameters in the entire energy range. The solution identified is a stack of adjustable slits, arranged with a relative rotation around the beam axis to obtain an hole with an approximately circular shape. In this contribution, the final collimation design and its performance evaluated by carrying out a series of detailed Geant4 simulations both of the high-energy and the low-energy beamline are presented

Electromagnetic form factors in the light-front formalism and the Feynman triangle diagram: spin-0 and spin-1 two-fermion systems

The connection between the Feynman triangle diagram and the light-front formalism for spin-0 and spin-1 two-fermion systems is analyzed. It is shown that in the limit q+ = 0 the form factors for both spin-0 and spin-1 systems can be uniquely determined using only the good amplitudes, which are not affected by spurious effects related to the loss of rotational covariance present in the light-front formalism. At the same time, the unique feature of the suppression of the pair creation process is maintained. Therefore, a physically meaningful one-body approximation, in which all the constituents are on their mass-shells, can be consistently formulated in the limit q+ = 0. Moreover, it is shown that the effects of the contact term arising from the instantaneous propagation of the active constituent can be canceled out from the triangle diagram by means of an appropriate choice of the off-shell behavior of the bound state vertexes; this implies that in case of good amplitudes the Feynman triangle diagram and the one-body light-front result match exactly. The application of our covariant light-front approach to the evaluation of the rho-meson elastic form factors is presented.Comment: corrected typos in the reference