Identifying Human Kinase-Specific Protein Phosphorylation Sites by Integrating Heterogeneous Information from Various Sources

Phosphorylation is an important type of protein post-translational modification. Identification of possible phosphorylation sites of a protein is important for understanding its functions. Unbiased screening for phosphorylation sites by in vitro or in vivo experiments is time consuming and expensive; in silico prediction can provide functional candidates and help narrow down the experimental efforts. Most of the existing prediction algorithms take only the polypeptide sequence around the phosphorylation sites into consideration. However, protein phosphorylation is a very complex biological process in vivo. The polypeptide sequences around the potential sites are not sufficient to determine the phosphorylation status of those residues. In the current work, we integrated various data sources such as protein functional domains, protein subcellular location and protein-protein interactions, along with the polypeptide sequences to predict protein phosphorylation sites. The heterogeneous information significantly boosted the prediction accuracy for some kinase families. To demonstrate potential application of our method, we scanned a set of human proteins and predicted putative phosphorylation sites for Cyclin-dependent kinases, Casein kinase 2, Glycogen synthase kinase 3, Mitogen-activated protein kinases, protein kinase A, and protein kinase C families (avaiable at http://cmbi.bjmu.edu.cn/huphospho). The predicted phosphorylation sites can serve as candidates for further experimental validation. Our strategy may also be applicable for the in silico identification of other post-translational modification substrates

CCAC Open Poetry Reading flyer, 1986

CCAC Open Poetry Reading flyer, October 8 198

4th Annual Career Day

Announcement mailer for the 4th annual Career Day, with Bay Area panelists discussing starting and maintaining a fine arts career, at Nahl Hall on CCAC's Oakland Campus, April 10, 1993

CCAC Gender Forum

Announcement flyer for the CCAC Gender Forum, a week long series of events and discussions on gender, at Nahl Hall on CCAC's Oakland Campus, February 8-12, 1993

Rapport sur l'observation des elections communales au Rwanda

Document collected by the University of Texas Libraries from the web-site of the Reseau Documentaire International Sur La Region Des Grands Lacs Africains (International Documentation Network on the Great African Lakes Region). The Reseau distributes "gray literature", non-published or limited distribution government or NGO documents regarding the Great Lakes area of central Africa including Rwanda, Burundi, and the Democratic Republic of Congo.UT Librarie

Lowering organic waste methane (low-methane): supporting ambitious subnational waste methane reduction : jurisdiction portfolio : Santo Domingo, Dominican Republic

This LOW-Methane Portfolio summarises Santo Domingo’s overall targets for ambitious methane reductions in the waste sector, priority goals, and current and proposed lines of action. It is subject to further change as this work evolves. This portfolio is intended to serve as a basis for discussions about the next steps, including with partners that are exploring providing additional support to the Santo Domingo team to advance this work. To advance Dominican Republic’s first NDC (2020), Santo Domingo is working on better collection, treatment, and disposal of waste, including landfill gas capture and use and waste-derived byproducts for energy purposes and as organic fertilizers. This work also leverages the country’s General Law for the Integrated Management and Co-Processing of Solid Waste, implementing the National Plan for Integrated Waste Management (PLANGIR), and the IDB-supported Program for the Integrated and Sustainable Management of Solid Waste in Great Santo Domingo