Diffuse Gamma Rays: Galactic and Extragalactic Diffuse Emission

"Diffuse" gamma rays consist of several components: truly diffuse emission from the interstellar medium, the extragalactic background, whose origin is not firmly established yet, and the contribution from unresolved and faint Galactic point sources. One approach to unravel these components is to study the diffuse emission from the interstellar medium, which traces the interactions of high energy particles with interstellar gas and radiation fields. Because of its origin such emission is potentially able to reveal much about the sources and propagation of cosmic rays. The extragalactic background, if reliably determined, can be used in cosmological and blazar studies. Studying the derived "average" spectrum of faint Galactic sources may be able to give a clue to the nature of the emitting objects.Comment: 32 pages, 28 figures, kapproc.cls. Chapter to the book "Cosmic Gamma-Ray Sources," to be published by Kluwer ASSL Series, Edited by K. S. Cheng and G. E. Romero. More details can be found at http://www.gamma.mpe-garching.mpg.de/~aws/aws.htm

Behavioural Susceptibility Theory: Professor Jane Wardle and the Role of Appetite in Genetic Risk of Obesity

Purpose of Review: There is considerable variability in human body weight, despite the ubiquity of the 'obesogenic' environment. Human body weight has a strong genetic basis and it has been hypothesised that genetic susceptibility to the environment explains variation in human body weight, with differences in appetite being implicated as the mediating mechanism; so-called 'behavioural susceptibility theory' (BST), first described by Professor Jane Wardle. This review summarises the evidence for the role of appetite as a mediator of genetic risk of obesity. Recent Findings: Variation in appetitive traits is observable from infancy, drives early weight gain and is highly heritable in infancy and childhood. Obesity-related common genetic variants identified through genome-wide association studies show associations with appetitive traits, and appetite mediates part of the observed association between genetic risk and adiposity. Summary: Obesity results from an interaction between genetic susceptibility to overeating and exposure to an 'obesogenic' food environment

Strategic planning as the intentional production of a “Trading Zone”

For a long period of time there has been a kind of mirroring between the development of decision making models in Political science and the concepts and paradigms used in Planning theory. The dialogue has been interrupted when the "Garbage Can" model was proposed by Choen, March and Olsen in 1972: a model that emphasized the irreducible complexity of the policy processes. The article reconstructs this relationship and its evolution showing the influence of decision-making models on planning theory, and showing the difficulties of managing complexity for planners. The paper holds that interpreting planning processes through the lens of the "Trading zone" concept proposed by Peter Galison in the field of history of science could be an interesting way of dealing with the extreme complexity of contemporary planning problems. The conclusion is that the use of the Trading Zone concept is very promising to solve some dilemmas of planning theory and that it is particularly useful if we employ it in the growing area of strategic spatial planning

Efficient derivation of NPCs, spinal motor neurons and midbrain dopaminergic neurons from hESCs at 3% oxygen

This protocol has been designed to generate neural precursor cells (NPCs) from human embryonic stem cells (hESCs) using a physiological oxygen (O(2)) level of 3% and chemically defined conditions. The first stage involves suspension culture of hESC colonies at 3% O(2), where they acquire a neuroepithelial identity over two weeks. This timescale is comparable to that at 20% O(2), but survival is enhanced. Sequential application of retinoic acid (RA) and purmorphamine (PM), from day 14 to 28, directs differentiation towards spinal motor neurons. Alternatively, addition of FGF-8 and PM generates midbrain dopaminergic neurons. OLIG2 induction in motor neuron precursors is 2-fold greater than at 20% O(2), whereas EN1 is 5-fold enhanced. 3% NPCs can be differentiated into all three neural lineages, and such cultures can be maintained long-term in the absence of neurotrophins. The ability to generate defined cell types at 3% O(2) should represent a significant advance for in vitro disease modelling and potentially cell-based therapies

Extreme behavioural shifts by baboons exploiting risky, resource-rich, human-modified environments

Abstract A range of species exploit anthropogenic food resources in behaviour known as ‘raiding’. Such behavioural flexibility is considered a central component of a species’ ability to cope with human-induced environmental changes. Here, we study the behavioural processes by which raiding male chacma baboons (Papio ursinus) exploit the opportunities and mitigate the risks presented by raiding in the suburbs of Cape Town, South Africa. Ecological sampling and interviews conducted with ‘rangers’ (employed to manage the baboons’ space use) revealed that baboons are at risk of being herded out of urban spaces that contain high-energy anthropogenic food sources. Baboon-attached motion/GPS tracking collars showed that raiding male baboons spent almost all of their time at the urban edge, engaging in short, high-activity forays into the urban space. Moreover, activity levels were increased where the likelihood of deterrence by rangers was greater. Overall, these raiding baboons display a time-activity balance that is drastically altered in comparison to individuals living in more remote regions. We suggest our methods can be used to obtain precise estimates of management impact for this and other species in conflict with people

The muon system of the Daya Bay Reactor antineutrino experiment

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Search for a Light Sterile Neutrino at Daya Bay

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Do family learning phonics courses improve parents’ reading-related skills and ability to support their children’s reading?

Background: Parents play a crucial role in supporting children’s literacy, especially in the first years of school. However, parents can find this challenging if they struggle with reading themselves. We explore whether family learning phonics courses boost parents’ reading-related skills and ability to support their children’s reading, in a collaboration between UK academics and the National Family Learning Forum. Methods: Prior to data collection, academics and course leaders identified key skills for courses to target: phonological awareness, letter-sounds, segmenting and blending, and awareness of irregular words. Family learning teams recruited parents of Reception children (aged 4-5 years old) for the Phonics group (N = 50), targeting parents who were likely to need literacy support. Parents received six weeks of one- to two-hour phonics sessions in groups. Control participants (N = 76) were recruited online and had a Reception-age child (4-5 years old); controls received no training. All participants completed phonics-related tests at weeks one and six. Results The Phonics group significantly improved on letter-sound knowledge (by 4.64 letters; 51 total items); the Control group did not significantly improve on this measure. Both groups showed some improvement in phonological awareness and word reading (likely due to practice effects), and neither group improved on nonword reading. The reading questionnaire showed that the Phonics group reported giving their children more regular support with literacy activities and placed a higher level of importance on homework, with no increase for the Control group. Conclusions: We provide evidence that family learning phonics courses can improve crucial reading skills (letter-sound knowledge) and increase parents’ confidence to support their children’s reading. Some reading skills (phonological awareness, whole word reading, and decoding) may be slower to change and require longer-term support. Future work should explore long-term consequences of such courses for parents’ and their children’s reading habits and skills

Independent measure of the neutrino mixing angle θ13 via neutron capture on hydrogen at Daya Bay

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