Modeling saturated and unsaturated ferroelectric hysteresis loops : an analytical approach

Author name used in this publication: C. H. TsangAuthor name used in this publication: C. K. WongAuthor name used in this publication: F. G. Shin2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Explicit expressions for the dynamic polarization behavior in ferroelectrics with symmetric/asymmetric electrical conductivity

Author name used in this publication: C. K. WongAuthor name used in this publication: C. H. TsangAuthor name used in this publication: F. G. Shin2004-2005 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

The role of cigarette smoking and its interaction with cyclooxygenase-2 in acute ulcerative colitis in mice

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Modeling of bias-field-dependent dielectric properties in ferroelectric thin films

Author name used in this publication: C. K. WongAuthor name used in this publication: C. H. TsangAuthor name used in this publication: F. G. Shin2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Polysaccharides from the root of Angelica sinensis protect bone marrow and gastrointestinal tissues against the cytotoxicity of cyclophosphamide in mice

Cyclophosphamide (CY) is a cytostatic agent that produces systemic toxicity especially on cells with high proliferative capacity, while polysaccharides from Angelica sinensis (AP) have been shown to increase the turnover of gastrointestinal mucosal and hemopoietic stem cells. It is not known whether AP has an effect on CY-induced cytotoxicity on bone marrow and gastrointestinal tract. In this study, we assessed the protective actions of AP on CY-induced leukopenia and proliferative arrest in the gastroduodenal mucosa in mice. Subcutaneous injection of CY (200 mg/kg) provoked dramatic decrease in white blood cell (WBC) count and number of blood vessels and proliferating cells in both the gastric and duodenal mucosae. Subcutaneous injection of AP significantly promoted the recovery from leukopenia and increased number of blood vessels and proliferating cells in both the gastric and duodenal tissues. Western blotting revealed that CY significantly down-regulated the protein expression of vascular endothelial growth factor (VEGF), c-Myc and ornithine decarboxylase (ODC) in gastric mucosae but had no effect on epidermal growth factor (EGF) expression. AP also reversed the dampening effect of CY on VEGF expression in the gastric mucosa. These data suggest that AP is a cytoprotective agent which can protect against the cytotoxicity of CY on hematopoietic and gastrointestinal tissues when the polysaccharide is co-administered with CY in cancer patients during treatment regimen.published_or_final_versio

Cigarette smoke promoted human xenograft tumors through the upregulation of cyclin D1 and cyclin-dependent kinases

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Effects of polarization and permittivity gradients and other parameters on the anomalous vertical shift behavior of graded ferroelectric thin films

Author name used in this publication: Y. ZhouAuthor name used in this publication: C. H. LamAuthor name used in this publication: F. G. Shin2005-2006 > Academic research: refereed > Publication in refereed journalVersion of RecordPublishe

Mechanism of inflammation-associated colonic tumorigenesis promoted by cigarette smoke

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Anti-tumorigenic and Pro-apoptotic effects of CKBM on gastric cancer growth in nude mice

Natural botanical products can be integrated with western medicine to optimize the treatment outcome, increase immune function and minimize the side effects from western drug treatment. CKBM is a combination of herbs and yeasts formulated based on traditional Chinese medicinal principles. Previous study has demonstrated that CKBM is capable of improving immune responsiveness through the induction of cytokine mediators, such as TNF-α and IL-6. In this study, we aimed to investigate the effect of this immunomodulatory drug on gastric cancer growth using a human xenograft model. Gastric cancer tissues were implanted subcutaneously into athymic nude mice followed by a 14-day or 28-day of CKBM treatment. Results showed that higher doses of CKBM (0.4 or 0.8 ml/mouse/day) produced a dose-dependent inhibitory effect on gastric tumor growth after 28-day drug treatment. This was associated with a decrease of cellular proliferation by 30% with concomitant increase in apoptosis by 97% in gastric tumor cells when compared with the control group. In contrast, CKBM showed no effect on angiogenesis in gastric tumors. This study demonstrates the anti-tumorigenic action of CKBM on gastric cancer probably via inhibition of cell proliferation and induction of apoptosis, and provides future potential targets of this drug candidate on cancer therapy.published_or_final_versio