Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer’s disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD

Yield and quality of tomato produced on substrates and with application of humic acids Produtividade e qualidade de tomate produzido em substratos e com aplicação de ácidos húmicos

The aim of this work was to evaluate the yield and quality of tomato fruits, hybrid "Vênus", produced on substrates and with application of nutrient solution and humic acids (AH). Four doses of AH were evaluated (0, 20, 40 and 80 L ha-1) and 4 substrates: S1 (coconut fiber (CF)), S2 (FC + carbonized coffee husk (CC) in the ratio 1:3), S3 (CF + CC in the ratio 2:3) and S4 (CC), were evaluated following the randomized blocks design in factorial 4x4 scheme with four replications. The 35-day old seedlings were transplanted into plastic bags of 7 L. The humic acids were applied four times in eight-day intervals, and the first application was carried out eight days after transplanting. There was no significant effect of AH on the yield and quality of fruit, except in relation to soluble solids (SS)/titratable acidity (AT). Doses of up to 36 L ha-1, increase the AT, above that amount favored increase of SS. The carbonized coffee husk in treatments S2, S3 and S4, did not alter the production of small fruits, medium, non-commercial, moisture, pH, SS, AT and SS/AT, however, significantly reduced the total production, commercial and large size fruit. The production of fruits in S1 was significantly higher compared to the other treatments, with an average of 142.6 t ha-1, showing average increase in yield of 24.4%, 29.3% and 36.1% compared to plant of treatments S2, S3 and S4, respectively.<br>Este trabalho foi realizado com o objetivo de avaliar a produtividade e qualidade de frutos de tomateiro, híbrido Vênus, produzidos em substratos, com aplicação de solução nutritiva e de ácidos húmicos (AH). Foram avaliadas 4 doses de AH (0, 20, 40 e 80 L ha-1) e 4 substratos: S1 (fibra de coco (FC)), S2 (FC + casca de café carbonizada (CC) na proporção 1:3), S3 (FC + CC na proporção 2:3) e S4 (CC). O delineamento experimental foi em blocos casualizados distribuídos em esquema fatorial 4x4. As mudas foram transplantadas com 35 dias para sacolas plásticas com capacidade de 7 L. Os AH foram aplicados quatro vezes em um intervalo de oito dias, sendo a primeira aplicação oito dias após o transplantio. Não houve efeito significativo dos AH sobre a produtividade e a qualidade de frutos, exceto na relação sólidos solúveis (SS)/acidez titulável (AT). Doses de até 36 L ha-1 aumentaram AT, porém, acima desse valor, favoreceram o incremento de SS. A casca de café carbonizada, nos tratamentos S2, S3 e S4, não alterou a produção de frutos pequenos, médios, não-comerciais, umidade, pH, SS, AT e SS/AT, porém, diminuiu significativamente a produção total, comercial e de frutos grandes. A produção de frutos comerciais em S1 foi significativamente superior à das plantas dos demais tratamentos, com média de 142,6 t ha-1, apresentando aumento médio de produtividade de 24,4%, 29,3% e 36,1%, em relação às plantas dos tratamentos S2, S3 e S4, respectivamente

Transferability of European-derived Alzheimer’s Disease Polygenic Risk Scores across Multi-Ancestry Populations

International audience A polygenic score (PGS) for Alzheimer’s disease (AD) was recently derived from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with AD risk, age at onset, and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E (APOE) . This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score (PRS) improved the association with AD risk in most of the multi-ancestry populations tested when the APOE region was included. Lastly, we found that the PGS/PRS, captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, but studies of more diverse populations are still needed for a better characterization of the AD genetics

Transferability of European-derived Alzheimer’s Disease Polygenic Risk Scores across Multi-Ancestry Populations

International audienceA polygenic score (PGS) for Alzheimer’s disease (AD) was recently derived from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with AD risk, age at onset, and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E (APOE) . This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score (PRS) improved the association with AD risk in most of the multi-ancestry populations tested when the APOE region was included. Lastly, we found that the PGS/PRS, captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, but studies of more diverse populations are still needed for a better characterization of the AD genetics

Transferability of European-derived Alzheimer's disease polygenic risk scores across multiancestry populations

A polygenic score (PGS) for Alzheimer's disease (AD) was derived recently from data on genome-wide significant loci in European ancestry populations. We applied this PGS to populations in 17 European countries and observed a consistent association with the AD risk, age at onset and cerebrospinal fluid levels of AD biomarkers, independently of apolipoprotein E locus (APOE). This PGS was also associated with the AD risk in many other populations of diverse ancestries. A cross-ancestry polygenic risk score improved the association with the AD risk in most of the multiancestry populations tested when the APOE region was included. Finally, we found that the PGS/polygenic risk score captured AD-specific information because the association weakened as the diagnosis was broadened. In conclusion, a simple PGS captures the AD-specific genetic information that is common to populations of different ancestries, although studies of more diverse populations are still needed to better characterize the genetics of AD.Lena Kilander och Malin Löwenmark ingår i forskargruppen EADB.</p